ID   PAX_I78A3               Reviewed;         252 AA.
AC   P0DJS8;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   10-FEB-2021, entry version 29.
DE   RecName: Full=Protein PA-X;
GN   Name=PA;
OS   Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX   NCBI_TaxID=384502;
OH   NCBI_TaxID=8782; Aves.
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=2483012; DOI=10.1016/0168-1702(89)90006-3;
RA   Treanor J., Kawaoka Y., Miller R., Webster R.G., Murphy B.;
RT   "Nucleotide sequence of the avian influenza A/Mallard/NY/6750/78 virus
RT   polymerase genes.";
RL   Virus Res. 14:257-270(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10769071; DOI=10.1099/0022-1317-81-5-1283;
RA   Naffakh N., Massin P., Escriou N., Crescenzo-Chaigne B., van der Werf S.;
RT   "Genetic analysis of the compatibility between polymerase proteins from
RT   human and avian strains of influenza A viruses.";
RL   J. Gen. Virol. 81:1283-1291(2000).
CC   -!- FUNCTION: May play a role in the modulation of host immune response.
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=2;
CC       Name=PA-X;
CC         IsoId=P0DJS8-1; Sequence=Displayed;
CC       Name=PA;
CC         IsoId=P31342-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the influenza viruses PA-X family.
CC       {ECO:0000305}.
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DR   EMBL; AJ243994; -; NOT_ANNOTATED_CDS; mRNA.
DR   SMR; P0DJS8; -.
DR   Proteomes; UP000098172; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   Gene3D; 3.40.91.90; -; 1.
DR   InterPro; IPR001009; PA/PA-X.
DR   InterPro; IPR038372; PA/PA-X_sf.
DR   Pfam; PF00603; Flu_PA; 1.
PE   2: Evidence at transcript level;
KW   Ribosomal frameshifting.
FT   CHAIN           1..252
FT                   /note="Protein PA-X"
FT                   /id="PRO_0000419391"
SQ   SEQUENCE   252 AA;  29361 MW;  455A2E667499B5A0 CRC64;
     MEDFVRQCFN PMIVELAEKA MKEYGEDPKI ETNKFAAICT HLEVCFMYSD FHFIDERGES
     IIVESGDPNA LLKHRFEIIE GRDRTMAWTV VNSICNTTGV EKPKFLPDLY DYKENRFIEI
     GVTRREVHIY YLEKANKIKS EKTHIHIFSF TGEEMATKAD YTLDEESRAR IKTRLFTIRQ
     EMASRGLWDS FVSPREAKRQ LKKDLKSQEP CAGLPTKVSH RTSPALKTLE PMWMDSNRTA
     ALRASFLKCQ KK