ID   ASP2_ANISI              Reviewed;          77 AA.
AC   O77417;
DT   16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Serine protease inhibitor 2;
DE   AltName: Full=ASPI-2;
DE   Flags: Precursor;
OS   Anisakis simplex (Herring worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Anisakidae; Anisakis;
OC   Anisakis simplex complex.
OX   NCBI_TaxID=6269;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9635450; DOI=10.1006/expr.1998.4284;
RA   Lu C.C., Nguyen T., Morris S., Hill D., Sakanari J.A.;
RT   "Anisakis simplex: mutational bursts in the reactive site centers of serine
RT   protease inhibitors from an ascarid nematode.";
RL   Exp. Parasitol. 89:257-261(1998).
CC   -!- FUNCTION: Defends the organism against the host's proteinases.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR   EMBL; U94497; AAC61298.1; -; mRNA.
DR   AlphaFoldDB; O77417; -.
DR   SMR; O77417; -.
DR   MEROPS; I08.005; -.
DR   Proteomes; UP000036680; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   SUPFAM; SSF57567; SSF57567; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Protease inhibitor; Secreted; Serine protease inhibitor;
KW   Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..77
FT                   /note="Serine protease inhibitor 2"
FT                   /id="PRO_0000034307"
FT   DOMAIN          21..74
FT                   /note="TIL"
FT   SITE            46..47
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
FT   DISULFID        21..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        30..48
FT                   /evidence="ECO:0000250"
FT   DISULFID        33..44
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..74
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..68
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   77 AA;  8699 MW;  965F588F01F0511F CRC64;
     MMFTPLIVLT LLVLATAEHQ CGPNEQWSDC PKCELQCGES DKPCATICGE PKCYCSPDKY
     RRIPDGRCIR KIQCPQH