ID   PAX_I80A2               Reviewed;         252 AA.
AC   P0DJU3;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   02-DEC-2020, entry version 29.
DE   RecName: Full=Protein PA-X;
GN   Name=PA;
OS   Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX   NCBI_TaxID=384493;
OH   NCBI_TaxID=8782; Aves.
OH   NCBI_TaxID=9796; Equus caballus (Horse).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9709; Phocidae (true seals).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=SC35M mouse-adapted;
RX   PubMed=16339318; DOI=10.1073/pnas.0507415102;
RA   Gabriel G., Dauber B., Wolff T., Planz O., Klenk H.D., Stech J.;
RT   "The viral polymerase mediates adaptation of an avian influenza virus to a
RT   mammalian host.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:18590-18595(2005).
CC   -!- FUNCTION: May play a role in the modulation of host immune response.
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=2;
CC       Name=PA-X;
CC         IsoId=P0DJU3-1; Sequence=Displayed;
CC       Name=PA;
CC         IsoId=Q2VC91-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the influenza viruses PA-X family.
CC       {ECO:0000305}.
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DR   EMBL; DQ266099; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   SMR; P0DJU3; -.
DR   Proteomes; UP000008576; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   Gene3D; 3.40.91.90; -; 1.
DR   InterPro; IPR001009; PA/PA-X.
DR   InterPro; IPR038372; PA/PA-X_sf.
DR   Pfam; PF00603; Flu_PA; 1.
PE   3: Inferred from homology;
KW   Ribosomal frameshifting.
FT   CHAIN           1..252
FT                   /note="Protein PA-X"
FT                   /id="PRO_0000419406"
SQ   SEQUENCE   252 AA;  29385 MW;  ED0E67ADF5982477 CRC64;
     MEDFVRQCFN PMIVELAEKA MKEYGEDPKI ETNKFAAICT HLEVCFMYSD FHFVDERGES
     IIVESGDPNA LLKHRFEIIE GRDRTMAWTV VNSICNTTGI EKPKFLPDLY DYKENRFIEI
     GVTRREVHIY YLEKANKIKS EKTHIHIFSF TGEEMATKAD YTLDEESRAR IKTRLFTIRQ
     EMASRGLWDS FVNPREAKRQ LKKDLKLQEP CAGSPTKVSH RTSPALKTLE PMWMDSNRTA
     ALRASFLKCP RK