ID   PAX_I97A1               Reviewed;         252 AA.
AC   P0DJR8;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   02-DEC-2020, entry version 25.
DE   RecName: Full=Protein PA-X;
GN   Name=PA;
OS   Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX   NCBI_TaxID=130763;
OH   NCBI_TaxID=8782; Aves.
OH   NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9691; Panthera pardus (Leopard) (Felis pardus).
OH   NCBI_TaxID=9694; Panthera tigris (Tiger).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=9658115; DOI=10.1128/jvi.72.8.6678-6688.1998;
RA   Suarez D.L., Perdue M.L., Cox N., Rowe T., Bender C., Huang J.,
RA   Swayne D.E.;
RT   "Comparisons of highly virulent H5N1 influenza A viruses isolated from
RT   humans and chickens from Hong Kong.";
RL   J. Virol. 72:6678-6688(1998).
CC   -!- FUNCTION: May play a role in the modulation of host immune response.
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=2;
CC       Name=PA-X;
CC         IsoId=P0DJR8-1; Sequence=Displayed;
CC       Name=PA;
CC         IsoId=O89752-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the influenza viruses PA-X family.
CC       {ECO:0000305}.
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DR   EMBL; AF046095; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   SMR; P0DJR8; -.
DR   Proteomes; UP000008587; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   Gene3D; 3.40.91.90; -; 1.
DR   InterPro; IPR001009; PA/PA-X.
DR   InterPro; IPR038372; PA/PA-X_sf.
DR   Pfam; PF00603; Flu_PA; 1.
PE   3: Inferred from homology;
KW   Ribosomal frameshifting.
FT   CHAIN           1..252
FT                   /note="Protein PA-X"
FT                   /id="PRO_0000419381"
SQ   SEQUENCE   252 AA;  29303 MW;  CC26EC3FCD2A83B1 CRC64;
     MEDFVRQCFN PMIVELAEKT MKEYGEDPKI ETNKFAAICT HLEVCFMYSD FHFIDERGES
     IIVESGDPNA LLKHRFEIIE GRDRAMAWTV VNSICNTTGV DKPKFLPDLY DYKENRFTEI
     GVTRREVHIY YLEKANKIKS EETHIHIFSF TGEEMATKAD YTLDEESRAR IKTRLFTIRQ
     EMASRGLWDS FVSPREAKRQ LKKDLKSQGP CVGLPTKVSH LTSPALKTLE PMWMDLNRTA
     ALRASFLKCR KK