ID   PA_I01A1                Reviewed;         216 AA.
AC   Q809K1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   07-APR-2021, entry version 41.
DE   RecName: Full=Polymerase acidic protein;
DE   AltName: Full=RNA-directed RNA polymerase subunit P2;
DE   Flags: Fragment;
GN   Name=PA;
OS   Influenza A virus (strain A/Chicken/Hong Kong/YU562/2001 H5N1 genotype B).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX   NCBI_TaxID=196426;
OH   NCBI_TaxID=8782; Aves.
OH   NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9691; Panthera pardus (Leopard) (Felis pardus).
OH   NCBI_TaxID=9694; Panthera tigris (Tiger).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=12077307; DOI=10.1073/pnas.132268999;
RA   Guan Y., Peiris J.S.M., Lipatov A.S., Ellis T.M., Dyrting K.C., Krauss S.,
RA   Zhang L.J., Webster R.G., Shortridge K.F.;
RT   "Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong
RT   Kong SAR.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:8950-8955(2002).
CC   -!- FUNCTION: Implicated in endonuclease cleavage of capped RNA primers.
CC       Displays an elongation factor activity in viral RNA synthesis.
CC       Dispensable for viral transcription, but not replication (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Influenza RNA polymerase is composed of three subunits: PB1,
CC       PB2 and PA. {ECO:0000250}.
CC   -!- PTM: Phosphorylated on serines and threonines by host kinases,
CC       including human casein kinase II. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the influenza viruses PA family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF509196; AAO53039.1; -; Genomic_DNA.
DR   SMR; Q809K1; -.
DR   MEROPS; S62.001; -.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   InterPro; IPR001009; PA/PA-X.
DR   Pfam; PF00603; Flu_PA; 1.
PE   3: Inferred from homology;
KW   Phosphoprotein.
FT   CHAIN           <1..216
FT                   /note="Polymerase acidic protein"
FT                   /id="PRO_0000311130"
FT   NON_TER         1
SQ   SEQUENCE   216 AA;  24738 MW;  6A5B4F3D34C4EFB3 CRC64;
     DDFQLIPMIS KCRTKEGRRK TNLYGFIIKG RSHLRNDTDV VNFVSMEFSL TDPRLEPHKW
     EKYCVLEIGD MLLRTAVGQV SRPMFLYVRT NGTSKIKMKW GMEMRRCLLQ SLQQIESMIE
     AESSVKEKDM TKEFFENKSE TWPIGESPKG VEEGSIGKVC RTLLAKSVFN SLYASPQLEG
     FSAESRKLLL IAQALRDNLE PGPSILEGYM KQLRSA