ID   ASP2_STAA8              Reviewed;         522 AA.
AC   Q2FUW4;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Accessory Sec system protein Asp2;
DE   AltName: Full=Accessory secretory protein Asp2;
GN   Name=asp2; OrderedLocusNames=SAOUHSC_02987;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ISP479C;
RX   PubMed=18621893; DOI=10.1128/jb.00300-08;
RA   Siboo I.R., Chaffin D.O., Rubens C.E., Sullam P.M.;
RT   "Characterization of the accessory Sec system of Staphylococcus aureus.";
RL   J. Bacteriol. 190:6188-6196(2008).
CC   -!- FUNCTION: Part of the accessory SecA2/SecY2 system specifically
CC       required to export SraP, a serine-rich repeat cell wall protein encoded
CC       upstream in the same operon. {ECO:0000269|PubMed:18621893}.
CC   -!- SUBUNIT: Part of the accessory SecA2/SecY2 protein translocation
CC       apparatus required to export cell wall protein SraP.
CC   -!- DISRUPTION PHENOTYPE: No effect on cell growth, significantly reduces
CC       export of the cell wall protein SraP. The small amount that is exported
CC       seems to be glycosylated normally. {ECO:0000269|PubMed:18621893}.
CC   -!- SIMILARITY: Belongs to the accessory Sec system protein Asp2 family.
CC       {ECO:0000305}.
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DR   EMBL; CP000253; ABD31974.1; -; Genomic_DNA.
DR   RefSeq; WP_001137474.1; NZ_LS483365.1.
DR   RefSeq; YP_501436.1; NC_007795.1.
DR   AlphaFoldDB; Q2FUW4; -.
DR   SMR; Q2FUW4; -.
DR   STRING; 1280.SAXN108_2922; -.
DR   ESTHER; staa8-asp2; Asp2.
DR   EnsemblBacteria; ABD31974; ABD31974; SAOUHSC_02987.
DR   GeneID; 3921469; -.
DR   KEGG; sao:SAOUHSC_02987; -.
DR   PATRIC; fig|93061.5.peg.2694; -.
DR   eggNOG; COG1073; Bacteria.
DR   HOGENOM; CLU_041140_1_0_9; -.
DR   OMA; FEGYFMM; -.
DR   PRO; PR:Q2FUW4; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR022267; Asp2.
DR   Pfam; PF16929; Asp2; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   TIGRFAMs; TIGR03712; acc_sec_asp2; 1.
PE   3: Inferred from homology;
KW   Protein transport; Reference proteome; Translocation; Transport.
FT   CHAIN           1..522
FT                   /note="Accessory Sec system protein Asp2"
FT                   /id="PRO_0000414197"
SQ   SEQUENCE   522 AA;  59570 MW;  4F6571590469E866 CRC64;
     MPRKFRVLQI GGDDLEPIFQ HKKGVSWDYF DIGLFEFDSG YVEAIEAIVE AEGRFDFIYI
     QAPYSETLTN LLQMISEPYN TYVDESFWSV EYEQDENVQK YVVQPLHYRN IEERNNKLEA
     VSFSGQYGDK VSPKLALVHP NFKGDVVYQG NSELTLSGEF GKEFKPIASW QNNLVYDKDK
     VIQIWPEFDI DGAVELQYTF RLIQTGADGA LIEQIVLTDD MLDSPLEIPA KPFDAYISVT
     VKARGNGTVH LGPIHKRWSR LDMGQFLLGG SRFVDSQRQE FIYYFHPGDM KPPLNVYFSG
     YRTAEGFEGY YMMKRMNAPF LLIGDPRVEG GSFYIGSSEY EQGIINVIDE TLEKLNFKSH
     ELILSGLSMG SFGALYYGAQ LNPQAIIVGK PLVNIGTIAE HMRLLRPEEF GTALDVLVSN
     EGDTSQASIQ ALNQKFWQTF QKKSLSQTVF AIAYMQHDDY DPHAFQELLP VLTAHQARVM
     NRSIPGRHND DSPTIASWFV NFYNIILEDK FGRVQHAEKQ NI