ID   ASP3_STAA8              Reviewed;         319 AA.
AC   Q2FUW5;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Accessory Sec system protein Asp3;
DE   AltName: Full=Accessory secretory protein Asp3;
GN   Name=asp3; OrderedLocusNames=SAOUHSC_02986;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ISP479C;
RX   PubMed=18621893; DOI=10.1128/jb.00300-08;
RA   Siboo I.R., Chaffin D.O., Rubens C.E., Sullam P.M.;
RT   "Characterization of the accessory Sec system of Staphylococcus aureus.";
RL   J. Bacteriol. 190:6188-6196(2008).
CC   -!- FUNCTION: Part of the accessory SecA2/SecY2 system specifically
CC       required to export SraP, a serine-rich repeat cell wall protein encoded
CC       upstream in the same operon. {ECO:0000269|PubMed:18621893}.
CC   -!- SUBUNIT: Part of the accessory SecA2/SecY2 protein translocation
CC       apparatus required to export cell wall protein SraP.
CC   -!- DISRUPTION PHENOTYPE: No effect on cell growth, significantly reduces
CC       export of the cell wall protein SraP. The small amount that is exported
CC       seems to be glycosylated normally. {ECO:0000269|PubMed:18621893}.
CC   -!- SIMILARITY: Belongs to the accessory Sec system protein Asp3 family.
CC       {ECO:0000305}.
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DR   EMBL; CP000253; ABD31973.1; -; Genomic_DNA.
DR   RefSeq; WP_000916742.1; NZ_LS483365.1.
DR   RefSeq; YP_501435.1; NC_007795.1.
DR   AlphaFoldDB; Q2FUW5; -.
DR   SMR; Q2FUW5; -.
DR   STRING; 1280.SAXN108_2921; -.
DR   EnsemblBacteria; ABD31973; ABD31973; SAOUHSC_02986.
DR   GeneID; 3921468; -.
DR   KEGG; sao:SAOUHSC_02986; -.
DR   PATRIC; fig|93061.5.peg.2693; -.
DR   eggNOG; ENOG50315V3; Bacteria.
DR   HOGENOM; CLU_075563_0_0_9; -.
DR   OMA; GIVIHEW; -.
DR   PRO; PR:Q2FUW5; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR022259; Acessory_Sec_prot_Asp3.
DR   Pfam; PF15432; Sec-ASP3; 1.
DR   TIGRFAMs; TIGR03711; acc_sec_asp3; 1.
PE   3: Inferred from homology;
KW   Protein transport; Reference proteome; Translocation; Transport.
FT   CHAIN           1..319
FT                   /note="Accessory Sec system protein Asp3"
FT                   /id="PRO_0000414199"
SQ   SEQUENCE   319 AA;  36927 MW;  D4F0F11CDB3866A7 CRC64;
     MLKNKTFKVT WNYISQTTFM YGSKVSFSNG EVTFINPLMP SGLPIHEWLM LKQFSKYKSA
     PSLPILRRGQ HYKLHFDFDA TPAGSVYFII IFYNKNGTKL STEIVKSNSI TIQYPDEAYA
     YKIKMMNAAS TSLIFRCLTI TEMTHQYDLE YKSMRVTKIG DDQYGNDMIN VIIAEPSDTY
     PTISNDFLKL FGHVWLVERW MDDNIEGNIK QLKNDLQSQD TLKAINLISY GSKSNVFATY
     VAQHLGCKVY RTSHEDDDLK GWLTEHVPGN HELKDTNVEV YFKEEQDKHL NYMSRLMNPV
     RFLDYLDVSK LNGGEVNET