ID   PA_ISAV8                Reviewed;         578 AA.
AC   Q8V3T8;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   02-DEC-2020, entry version 34.
DE   RecName: Full=Polymerase acidic protein;
DE            Short=PA;
DE   AltName: Full=Protein 2;
DE            Short=P2;
DE   AltName: Full=RNA-directed RNA polymerase subunit P2;
GN   Name=Segment-4 {ECO:0000303|PubMed:20979983};
OS   Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99)
OS   (ISAV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Isavirus.
OX   NCBI_TaxID=652965;
OH   NCBI_TaxID=8049; Gadus morhua (Atlantic cod).
OH   NCBI_TaxID=8019; Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
OH   NCBI_TaxID=8022; Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OH   NCBI_TaxID=8060; Pollachius virens (Saithe) (Gadus virens).
OH   NCBI_TaxID=8030; Salmo salar (Atlantic salmon).
OH   NCBI_TaxID=8032; Salmo trutta (Brown trout).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=11807235; DOI=10.1099/0022-1317-83-2-421;
RA   Clouthier S.C., Rector T., Brown N.E., Anderson E.D.;
RT   "Genomic organization of infectious salmon anaemia virus.";
RL   J. Gen. Virol. 83:421-428(2002).
RN   [2]
RP   REVIEW.
RX   PubMed=20979983; DOI=10.1016/j.virusres.2010.10.021;
RA   Cottet L., Rivas-Aravena A., Cortez-San Martin M., Sandino A.M.,
RA   Spencer E.;
RT   "Infectious salmon anemia virus--genetics and pathogenesis.";
RL   Virus Res. 155:10-19(2011).
CC   -!- FUNCTION: Implicated in endonuclease cleavage of capped RNA primers.
CC       Displays an elongation factor activity in viral RNA synthesis.
CC       Dispensable for viral transcription, but not replication (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The RNA polymerase is composed of three subunits: PB1, PB2 and
CC       PA. {ECO:0000250}.
CC   -!- PTM: Phosphorylated on serines and threonines by host kinases.
CC       {ECO:0000250}.
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DR   EMBL; AF404344; AAL67960.1; -; Viral_cRNA.
DR   RefSeq; YP_145802.1; NC_006501.1.
DR   GeneID; 3170932; -.
DR   KEGG; vg:3170932; -.
DR   Proteomes; UP000008772; Genome.
PE   3: Inferred from homology;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..578
FT                   /note="Polymerase acidic protein"
FT                   /id="PRO_0000403916"
SQ   SEQUENCE   578 AA;  65266 MW;  07B3AE24F8CB7EC0 CRC64;
     MDNLRECINR KRRLLALPDV PETSDAFLSD LRHLYMCVAF CDQHKTTGDE SRFTNLELLD
     QDEALGAQRA FEAKHGIKGG SLGDVLDHEL KKVIEFTFTS GSLYIAEQRK RKTQADSIIV
     CVSEGLNDFS VSHGVLDMGL VETGVNAVRD FCTQNGIPMK INQVGSTRTP TPISTCKISE
     QITRQINSTI TERKMETVLA AIAIKPELKX TQKGCXXCKE LEDENILWMD PQFCEIDESF
     PYRGGPYGNF LQELLLTTND VETNGKDREE VVKXILDNKA FTVESGECII TLPDKMTCFG
     EQEKKRPATI DEVRTAGERF EQSVKPKTQR YGRLSDKWME LEKFIFTASK TEVDTFLSVG
     TERLESVGVC VGALHRATTT RIIRPMIQGG KCWGMMFKTK SKMGDTRKEG YCHAIIFGKG
     EDKSGQNKMT MMGKTVHWHL RVVKSKGDWM AQQLCANKSR IWQHDPELVT EGVTVLMTPF
     SQKIATISRW RAMRLDSMFH VSSAWHHSPA CEAASAMLRK FVEIVHAINQ KRDWGVVGSM
     EDMVKEVEEI GEHLQTACDF RVYNXCKALI QKIAVSTQ