ID   PA_QRFVE                Reviewed;         688 AA.
AC   D0UFC8;
DT   31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2009, sequence version 1.
DT   23-FEB-2022, entry version 35.
DE   RecName: Full=Polymerase acidic protein;
DE            Short=PA;
GN   Name=PA; OrderedLocusNames=Segment 3;
OS   Quaranfil virus (isolate QrfV/Tick/Afghanistan/EG_T_377/1968) (QRFV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Quaranjavirus.
OX   NCBI_TaxID=1559362;
OH   NCBI_TaxID=6939; Ixodidae (hardbacked ticks).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=19726499; DOI=10.1128/jvi.00677-09;
RA   Presti R.M., Zhao G., Beatty W.L., Mihindukulasuriya K.A., da Rosa A.P.,
RA   Popov V.L., Tesh R.B., Virgin H.W., Wang D.;
RT   "Quaranfil, Johnston Atoll, and Lake Chad viruses are novel members of the
RT   family Orthomyxoviridae.";
RL   J. Virol. 83:11599-11606(2009).
CC   -!- FUNCTION: subunit of the RNA-dependent RNA polymerase which is
CC       responsible for replication and transcription of virus RNA segments.
CC       The transcription of viral mRNAs occurs by a unique mechanism called
CC       cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after
CC       10-13 nucleotides by PA. In turn, these short capped RNAs are used as
CC       primers by PB1 for transcription of viral mRNAs. During virus
CC       replication, PB1 initiates RNA synthesis and copy vRNA into
CC       complementary RNA (cRNA) which in turn serves as a template for the
CC       production of more vRNAs. {ECO:0000250|UniProtKB:P03433}.
CC   -!- SUBUNIT: RNA polymerase is composed of three subunits: PA, PB1 and PB2.
CC       {ECO:0000250|UniProtKB:P03431}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus {ECO:0000305}.
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DR   EMBL; GQ499303; ACY56279.1; -; Genomic_RNA.
DR   Proteomes; UP000029941; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome; Virion.
FT   CHAIN           1..688
FT                   /note="Polymerase acidic protein"
FT                   /id="PRO_0000443070"
FT   REGION          54..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          110..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   688 AA;  78456 MW;  5764AF2B55751347 CRC64;
     MAFEAYRLLI ANPQLYEPDF VSQAGELSEH WARENWKRRE ESLRHDKVCM LLMNTEPRER
     SHTQAEGEEE GSSSRSLATE EGEKRFSLEA LEGLVDQGRE VLLENLEMEE AQANSDSEGP
     NEADSGGEGE EFVFGVESES EMEVASEVTK LLEPDLIDSN FRYTLLEGVT SGKFAQMEFT
     ALWGINTNNK WDLVDRVNRK LIEVKVTTRP PTGVWEEVVA HAEGTDPEHN GAYIIHDDLC
     GNFTPYKFGN ISDLPGWPSA QDFPIRRHAF LASYGGVPSA GGIEEGLPAW DDVFMERTRN
     WVAPLWKKGP ISVRRDDCPR MEPFNITKFI TLLEDPRLRN TDKSAKWKGK ILPVSWCRTI
     ISSQEKDIDM VQEVIRDLGV IGLWEEINAN PVKVERTVSA LSELMRLFQE GFREKNPYIS
     VKRKCKGWVI TGHKQTPALT DTLLELGVGY KPYQMSNVVE EDMRQCETDD IEKMKWVDWM
     SKLAATESEP LGSKVSRDDI FKEAESRHVL DEPAKKMCSK VYDLYRSHKI GATCSKFMGF
     YSRMGGSYLR AIAGNSRQHS SLAIMPLYYK TYQEDGTSTR HLTGLVIRGP HHVRESTDTI
     NLLIVEKTCL SRREAQERLS GGALVNGVWW VRKNAIRKAD PTYLAFLHNS LFVPTNFLGE
     LVTTPKHFLR QRQPRILGRN PVWQLWLL