ASP4_STRGN
ID ASP4_STRGN Reviewed; 60 AA.
AC Q4L2X3;
DT 14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 23.
DE RecName: Full=Accessory secretory protein Asp4;
DE AltName: Full=Orf5;
GN Name=asp4;
OS Streptococcus gordonii.
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1302;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=M99;
RX PubMed=15901716; DOI=10.1128/jb.187.11.3878-3883.2005;
RA Takamatsu D., Bensing B.A., Sullam P.M.;
RT "Two additional components of the accessory sec system mediating export of
RT the Streptococcus gordonii platelet-binding protein GspB.";
RL J. Bacteriol. 187:3878-3883(2005).
CC -!- FUNCTION: Part of the accessory SecA2/SecY2 system specifically
CC required to export GspB, a serine-rich repeat cell wall protein encoded
CC upstream in the same operon. {ECO:0000269|PubMed:15901716}.
CC -!- SUBUNIT: Part of the accessory SecA2/SecY2 protein translocation
CC apparatus required to export cell wall protein GspB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: No export of mature cell wall protein GspB, a
CC small amount of unprocessed protein is exported to the cell wall while
CC the rest accumulates intracellularly, probably in a glycosylated form.
CC Cells bind less well to platelets. {ECO:0000269|PubMed:15901716}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY028381; AAY99443.1; -; Genomic_DNA.
DR RefSeq; WP_045634942.1; NZ_RJVY01000036.1.
DR AlphaFoldDB; Q4L2X3; -.
DR SMR; Q4L2X3; -.
DR PRIDE; Q4L2X3; -.
DR OrthoDB; 2090625at2; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR031551; Asp4.
DR Pfam; PF16996; Asp4; 1.
PE 4: Predicted;
KW Cell membrane; Membrane; Protein transport; Translocation; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..60
FT /note="Accessory secretory protein Asp4"
FT /id="PRO_0000414201"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 60 AA; 6728 MW; DE863B34D264ACF5 CRC64;
MAKKDLFHKD IEGRLDELKH GKPKKEKASL GENLNKIFVI ALGLMILIGL IFTLIGALRK