PB1F2_I60A0
ID PB1F2_I60A0 Reviewed; 90 AA.
AC P0C2M2;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 23-FEB-2022, entry version 61.
DE RecName: Full=Protein PB1-F2 {ECO:0000255|HAMAP-Rule:MF_04064};
GN Name=PB1 {ECO:0000255|HAMAP-Rule:MF_04064};
OS Influenza A virus (strain A/Ann Arbor/6/1960 H2N2).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX NCBI_TaxID=384498;
OH NCBI_TaxID=8782; Aves.
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=2974219; DOI=10.1016/s0042-6822(88)90118-3;
RA Cox N.J., Kitame F., Kendal A.P., Maassab H.F., Naeve C.;
RT "Identification of sequence changes in the cold-adapted, live attenuated
RT influenza vaccine strain, A/Ann Arbor/6/60 (H2N2).";
RL Virology 167:554-567(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=15380362; DOI=10.1016/j.virol.2004.06.009;
RA Lindstrom S.E., Cox N.J., Klimov A.;
RT "Genetic analysis of human H2N2 and early H3N2 influenza viruses, 1957-
RT 1972: evidence for genetic divergence and multiple reassortment events.";
RL Virology 328:101-119(2004).
CC -!- FUNCTION: Plays an important role in promoting lung pathology in both
CC primary viral infection and secondary bacterial infection. Promotes
CC alteration of mitochondrial morphology, dissipation of mitochondrial
CC membrane potential, and cell death. Alternatively, inhibits the
CC production of interferon in the infected cell at the level of host
CC mitochondrial antiviral signaling MAVS. Its level of expression differs
CC greatly depending on which cell type is infected, in a manner that is
CC independent of the levels of expression of other viral proteins.
CC Monocytic cells are more affected than epithelial cells. Seems to
CC disable virus-infected monocytes or other host innate immune cells.
CC During early stage of infection, predisposes the mitochondria to
CC permeability transition through interaction with host SLC25A6/ANT3 and
CC VDAC1. These proteins participate in the formation of the permeability
CC transition pore complex (PTPC) responsible of the release of
CC mitochondrial products that triggers apoptosis. {ECO:0000255|HAMAP-
CC Rule:MF_04064}.
CC -!- SUBUNIT: Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1.
CC Interacts with host MAVS. {ECO:0000255|HAMAP-Rule:MF_04064}.
CC -!- SUBCELLULAR LOCATION: Host mitochondrion inner membrane
CC {ECO:0000255|HAMAP-Rule:MF_04064}. Host nucleus {ECO:0000255|HAMAP-
CC Rule:MF_04064}. Host cytoplasm, host cytosol {ECO:0000255|HAMAP-
CC Rule:MF_04064}. Note=Inner mitochondrial membrane in most cells types.
CC Otherwise is detected in the nucleus and cytosol. {ECO:0000255|HAMAP-
CC Rule:MF_04064}.
CC -!- MISCELLANEOUS: Is not encoded in all strains, and seems to be
CC dispensable for replication.
CC -!- SIMILARITY: Belongs to the influenza viruses PB1-F2 family.
CC {ECO:0000255|HAMAP-Rule:MF_04064}.
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DR EMBL; M23972; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR EMBL; AY210012; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR SMR; P0C2M2; -.
DR GO; GO:0044164; C:host cell cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0044192; C:host cell mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0039545; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity; IEA:UniProtKB-KW.
DR HAMAP; MF_04064; INFV_PB1F2; 1.
DR InterPro; IPR021045; Flu_proapoptotic_PB1-F2.
DR Pfam; PF11986; PB1-F2; 1.
PE 3: Inferred from homology;
KW Apoptosis; Host cytoplasm; Host membrane; Host mitochondrion;
KW Host mitochondrion inner membrane; Host nucleus; Host-virus interaction;
KW Inhibition of host innate immune response by virus;
KW Inhibition of host MAVS by virus; Inhibition of host RLR pathway by virus;
KW Membrane; Modulation of host cell apoptosis by virus; Viral immunoevasion.
FT CHAIN 1..90
FT /note="Protein PB1-F2"
FT /id="PRO_0000281017"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..87
FT /note="Mitochondrial targeting sequence"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04064"
FT SITE 66
FT /note="Low pathogenicity"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04064"
SQ SEQUENCE 90 AA; 10998 MW; 6C90622FF5614EB5 CRC64;
MEQEQDTPWT QSTEHINIQK RGSGQQTRKL ERTNLTQLMD HYLRTMNQVD MHKQTASWKQ
WLSLKNPTQE SLKTRVLKRW KLFNKQEWTN
