ID   PB1F2_I96A2             Reviewed;          57 AA.
AC   A3DRP9;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   23-FEB-2022, entry version 44.
DE   RecName: Full=Protein PB1-F2 {ECO:0000255|HAMAP-Rule:MF_04064};
GN   Name=PB1 {ECO:0000255|HAMAP-Rule:MF_04064}; Synonyms=PB1-F2;
OS   Influenza A virus (strain A/USA:Memphis/10/1996 H1N1).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX   NCBI_TaxID=416730;
OH   NCBI_TaxID=8782; Aves.
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Ghedin E., Spiro D., Miller N., Zaborsky J., Feldblyum T., Subbu V.,
RA   Shumway M., Sparenborg J., Groveman L., Halpin R., Sitz J., Koo H.,
RA   Salzberg S.L., Webster R.G., Hoffmann E., Krauss S., Naeve C., Bao Y.,
RA   Bolotov P., Dernovoy D., Kiryutin B., Lipman D.J., Tatusova T.;
RT   "The NIAID influenza genome sequencing project.";
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RG   The NIAID Influenza Genome Sequencing Consortium;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play an important role in promoting lung pathology in
CC       both primary viral infection and secondary bacterial infection.
CC       {ECO:0000255|HAMAP-Rule:MF_04064}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04064}.
CC       Host cytoplasm, host cytosol {ECO:0000255|HAMAP-Rule:MF_04064}.
CC   -!- MISCELLANEOUS: Is not encoded in all strains, and seems to be
CC       dispensable for replication.
CC   -!- SIMILARITY: Belongs to the influenza viruses PB1-F2 family.
CC       {ECO:0000255|HAMAP-Rule:MF_04064}.
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DR   EMBL; CY019801; ABN50971.1; -; Viral_cRNA.
DR   Proteomes; UP000007557; Genome.
DR   GO; GO:0044164; C:host cell cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0039545; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity; ISS:UniProtKB.
DR   HAMAP; MF_04064; INFV_PB1F2; 1.
DR   InterPro; IPR021045; Flu_proapoptotic_PB1-F2.
DR   Pfam; PF11986; PB1-F2; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus.
FT   CHAIN           1..57
FT                   /note="Protein PB1-F2"
FT                   /id="PRO_0000373025"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   57 AA;  6524 MW;  F1B2088803B33FBA CRC64;
     MGQGQGTPWI QSTGHISTQK EEDGQKIPKL EHRNSTRLMG HYQKTMNQVA MPKQIVY