PB1_CHICK
ID PB1_CHICK Reviewed; 1633 AA.
AC Q90941;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein polybromo-1;
GN Name=PBRM1; Synonyms=PB1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND SUBUNIT.
RX PubMed=8917104; DOI=10.1016/0378-1119(96)82845-9;
RA Nicolas R.H., Goodwin G.H.;
RT "Molecular cloning of polybromo, a nuclear protein containing multiple
RT domains including five bromodomains, a turncated HMG-box, and two repeats
RT of a novel domain.";
RL Gene 175:233-240(1996).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 932-1103, AND STRUCTURE BY NMR.
RX PubMed=15839835; DOI=10.1042/bj20050310;
RA Oliver A.W., Jones S.A., Roe S.M., Matthews S., Goodwin G.H., Pearl L.H.;
RT "Crystal structure of the proximal BAH domain of the polybromo protein.";
RL Biochem. J. 389:657-664(2005).
CC -!- FUNCTION: Involved in transcriptional activation and repression of
CC select genes by chromatin remodeling (alteration of DNA-nucleosome
CC topology). {ECO:0000250}.
CC -!- SUBUNIT: Component of the SWI/SNF-B (PBAF) chromatin-remodeling
CC complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267,
CC ECO:0000269|PubMed:8917104}.
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DR EMBL; X90849; CAA62353.1; -; mRNA.
DR PIR; JC5056; JC5056.
DR RefSeq; NP_990496.1; NM_205165.1.
DR PDB; 1W4S; X-ray; 1.55 A; A=932-1103.
DR PDBsum; 1W4S; -.
DR AlphaFoldDB; Q90941; -.
DR SMR; Q90941; -.
DR STRING; 9031.ENSGALP00000040734; -.
DR PaxDb; Q90941; -.
DR PRIDE; Q90941; -.
DR GeneID; 396074; -.
DR KEGG; gga:396074; -.
DR CTD; 55193; -.
DR VEuPathDB; HostDB:geneid_396074; -.
DR eggNOG; KOG1827; Eukaryota.
DR InParanoid; Q90941; -.
DR PhylomeDB; Q90941; -.
DR EvolutionaryTrace; Q90941; -.
DR PRO; PR:Q90941; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0016586; C:RSC-type complex; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR CDD; cd05515; Bromo_polybromo_V; 1.
DR Gene3D; 1.20.920.10; -; 6.
DR Gene3D; 2.30.30.490; -; 2.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR037968; PBRM1_BD5.
DR InterPro; IPR037382; Rsc/polybromo.
DR PANTHER; PTHR16062; PTHR16062; 2.
DR Pfam; PF01426; BAH; 2.
DR Pfam; PF00439; Bromodomain; 6.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00439; BAH; 2.
DR SMART; SM00297; BROMO; 6.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR SUPFAM; SSF47370; SSF47370; 6.
DR PROSITE; PS51038; BAH; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 5.
DR PROSITE; PS50014; BROMODOMAIN_2; 6.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Bromodomain; Chromatin regulator; DNA-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation.
FT CHAIN 1..1633
FT /note="Protein polybromo-1"
FT /id="PRO_0000223186"
FT DOMAIN 65..135
FT /note="Bromo 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT DOMAIN 197..267
FT /note="Bromo 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT DOMAIN 398..468
FT /note="Bromo 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT DOMAIN 536..606
FT /note="Bromo 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT DOMAIN 674..744
FT /note="Bromo 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT DOMAIN 790..860
FT /note="Bromo 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT DOMAIN 954..1072
FT /note="BAH 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00370"
FT DOMAIN 1155..1271
FT /note="BAH 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00370"
FT DNA_BIND 1378..1446
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 623..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 900..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1319..1377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1509..1531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..637
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..931
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1338..1369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 961..964
FT /evidence="ECO:0007829|PDB:1W4S"
FT STRAND 974..983
FT /evidence="ECO:0007829|PDB:1W4S"
FT STRAND 989..997
FT /evidence="ECO:0007829|PDB:1W4S"
FT HELIX 999..1001
FT /evidence="ECO:0007829|PDB:1W4S"
FT STRAND 1009..1011
FT /evidence="ECO:0007829|PDB:1W4S"
FT STRAND 1014..1025
FT /evidence="ECO:0007829|PDB:1W4S"
FT HELIX 1026..1028
FT /evidence="ECO:0007829|PDB:1W4S"
FT STRAND 1029..1037
FT /evidence="ECO:0007829|PDB:1W4S"
FT HELIX 1038..1041
FT /evidence="ECO:0007829|PDB:1W4S"
FT STRAND 1044..1046
FT /evidence="ECO:0007829|PDB:1W4S"
FT HELIX 1051..1053
FT /evidence="ECO:0007829|PDB:1W4S"
FT STRAND 1054..1062
FT /evidence="ECO:0007829|PDB:1W4S"
FT TURN 1063..1066
FT /evidence="ECO:0007829|PDB:1W4S"
FT STRAND 1067..1070
FT /evidence="ECO:0007829|PDB:1W4S"
FT STRAND 1083..1085
FT /evidence="ECO:0007829|PDB:1W4S"
FT STRAND 1094..1096
FT /evidence="ECO:0007829|PDB:1W4S"
SQ SEQUENCE 1633 AA; 187055 MW; E4CA350E1087F888 CRC64;
MGSKRRRATS PSSSVSGGDF DDGHHSTNIP GPSRKRRRLS NLPTVDPIAV CHELYNTIRD
YKDEQGRLLC ELFIRAPKRR NQPDYYEVVS QPIDLMKIQQ KLKMEEYDDV NVLTADFQLL
FNNAKAYYKP DSPEYKAACK LWELYLRTKN EFVQKGDAEE EDEDEEGHDS QELSSPGYLK
EILEQLLEAV AVATNPSGRL ISELFQKLPS KVQYPDYYAI IKEPIDLKTI AQRIQNGTYK
SIHAMAKDID LLAKNAKTYN EPGSQVFKDA NAIKKIFNMK KAEIEHSELA KSSLRLRTPS
NLTASKLTGP SSQGKGSVGD ERNSSNKYFR NKRSAQGDRL SAITMALQYG SESDEDAALA
AAARYEGESE AESITSFMDT SNPLYQLYDT VRSCRNNQGQ LISEPFFQLP SKKKYPDYYQ
QIKTPISLQQ IRAKLKNHEY ETLDQLEADL NLMFENAKRY NVPNSAIYKR VLKMQQVMQA
KKKELARRDD IEDGDSMISS ATSDTGSSKR KSKKNMRKQR MKILYNAVLE ARESGTGRRL
CDLFMVKPSK KDYPDYYKII LEPMDLKMIE HNIRNDKYVG EEAMIDDMKL MFRNARHYNE
EGSQVYNDAH MLEKILKEKR KELGPLPEDD DVASPKLKLS RKSGISPKKS KYMTPMQQKL
NEVYEAVKNY TDKRGRRLSA IFLRLPSRSE LPDYYITIKK PVDMEKIRSH MMANKYQDID
SMVEDFVMMF NNACTYNEPE SLIYKDALVL HKVLLETRRE IEGDEDSHVP NVTLLIQELI
HNLFVSVMSH QDDEGRCYSD SLAEIPAVDP NFPNKPPLTF DIIRKNVENN RYRRLDLFQE
NMFEVLERAR RMNRTDSEIY EDAVELQQFF IKIRDELCKN GEILLSPALS YTTKHLHNDV
EKEKKEKLPK EIEEDKLKRE EEKREAEKSE DSSGSAGLSS LHRTYSQDCS FKNSMYHVGD
YVYVEPAEAN LQPHIVCIER LWEDSAGEKW LYGCWFYRPN ETFHLATRKF LEKEVFKSDY
YNKVPVSKIL GKCVVMFVKE YFKLCPENFR DEDVYVCESR YSAKTKSFKK IKLWTMPVSS
VRFVPRDVPL PVVRVASVFA NTDKAEEEKH SDTLDDSKVG ESILHLEKDK EDVPVEMSNG
EPGCHYFEQL CYNDMWLKVG DCVFIKSHGL VRPRVGRIEK MWVRDGAAYF FGPIFIHPEE
TEHEPTKMFY KKEVFLSNLE ETCPMSCILG KCAVLSFKDF LCCRPTEISE NDVFLCESRY
NESDKQMKKF KGLKRFSLSA KVVDDEIYYF RKPIVPQKEP SPLLEKKIQQ LEAKFAELGG
GDEDMEEMGE EEGDITETPS MPQLQTPLTS ELDIMPYTPP QSTPKSVKGS TKKEGSKRKI
NMSGYILFSS EMRPVIKAQH PDYSFGELSR LVGTEWRNLE ATKKAEYEGM ISGYPPVLPP
LQGPVDGIVS MGSMQPLHPG VPPPHQLPPG MPGIPGIPPP GVIGQNVSPM VGTPAPGAGP
FGQQIGILGP PGQQAPPPYP GQSPATQPVM QQPSTPMFVS PPPKTQRLLH SEAYLKYIEG
LSAESNSISK WDQTLAARRR DVHLSKEQES RLPSHWLKSK GAHTTMADAL WRLRDLMLRD
TLNIRQAYNI ENV
