ID   PB2S1_I18A0             Reviewed;         507 AA.
AC   P0DOG7;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 1.
DT   07-OCT-2020, entry version 14.
DE   RecName: Full=PB2-S1;
GN   Name=PB2;
OS   Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus
OS   (strain A/South Carolina/1/1918 H1N1)).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX   NCBI_TaxID=88776;
OH   NCBI_TaxID=8782; Aves.
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16208372; DOI=10.1038/nature04230;
RA   Taubenberger J.K., Reid A.H., Lourens R.M., Wang R., Jin G., Fanning T.G.;
RT   "Characterization of the 1918 influenza virus polymerase genes.";
RL   Nature 437:889-893(2005).
CC   -!- FUNCTION: May participate in the inhibition of type I interferon
CC       induction through inhibition of the host mitochondrial antiviral
CC       signaling protein MAVS. The knockout of PB2-S1 has no detectable
CC       effects on laboratory infected mice. {ECO:0000250|UniProtKB:P0DOG3}.
CC   -!- SUBCELLULAR LOCATION: Host mitochondrion
CC       {ECO:0000250|UniProtKB:P0DOG3}. Host cytoplasm, host cytosol
CC       {ECO:0000250|UniProtKB:P0DOG3}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=PB2-S1 {ECO:0000250|UniProtKB:P03427};
CC         IsoId=P0DOG7-1; Sequence=Displayed;
CC       Name=Polymerase basic protein 2;
CC         IsoId=Q3HM41-1; Sequence=External;
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DR   EMBL; DQ208309; -; NOT_ANNOTATED_CDS; mRNA.
DR   SMR; P0DOG7; -.
DR   Proteomes; UP000008430; Genome.
DR   GO; GO:0044164; C:host cell cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   InterPro; IPR001591; INV_PB2.
DR   Pfam; PF00604; Flu_PB2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Host cytoplasm; Host mitochondrion.
FT   CHAIN           1..507
FT                   /note="PB2-S1"
FT                   /id="PRO_0000440605"
SQ   SEQUENCE   507 AA;  57669 MW;  FF049B8F2A543F20 CRC64;
     MERIKELRDL MSQSRTREIL TKTTVDHMAI IKKYTSGRQE KNPALRMKWM MAMKYPITAD
     KRIMEMIPER NEQGQTLWSK TNDAGSDRVM VSPLAVTWWN RNGPTTSAVH YPKIYKTYFE
     KVERLKHGTF GPVHFRNQVK IRRRVDINPG HADLSAKEAQ DVIMEVVFPN EVGARILTSE
     SQLTITKEKK EELQDCKISP LMVAYMLERE LVRKTRFLPV AGGTSSVYIE VLHLTQGTCW
     EQMYTPGGEV RNDDVDQSLI IAARNIVRRA TVSADPLASL LEMCHSTQIG GIRMVDILRQ
     NPTEEQAVDI CKAAMGLRIS SSFSFGGFTF KRTSGSSVKR EEEVLTGNLQ TLKIRVHEGY
     EEFTMVGRRA TAILRKATRR LIQLIVSGRD EQSIAEAIIV AMVFSQEDCM IKAVRGDLNF
     VNRANQRLNP MHQLLRHFQK DAKVLFQNWG IEPIDNVMGM IGILPDMTPS TEMSMRGVRV
     SKMGVDEYSS TERVPLHQSK VECSSPL