ID   PB2S1_I33A0             Reviewed;         508 AA.
AC   P0DOG3;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 1.
DT   03-AUG-2022, entry version 19.
DE   RecName: Full=PB2-S1;
GN   Name=PB2;
OS   Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus
OS   (strain A/WS/1933 H1N1)).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX   NCBI_TaxID=381518;
OH   NCBI_TaxID=8782; Aves.
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=7045393; DOI=10.1128/jvi.42.1.55-63.1982;
RA   Kaptein J.S., Nayak D.P.;
RT   "Complete nucleotide sequence of the polymerase 3 gene of human influenza
RT   virus A/WSN/33.";
RL   J. Virol. 42:55-63(1982).
RN   [2]
RP   CHARACTERIZATION, SUBCELLULAR LOCATION, AND ALTERNATIVE SPLICING.
RX   PubMed=26491155; DOI=10.1128/jvi.02175-15;
RA   Yamayoshi S., Watanabe M., Goto H., Kawaoka Y.;
RT   "Identification of a novel viral protein expressed from the PB2 segment of
RT   Influenza A virus.";
RL   J. Virol. 90:444-456(2015).
CC   -!- FUNCTION: May participate in the inhibition of type I interferon
CC       induction through inhibition of the host mitochondrial antiviral
CC       signaling protein MAVS. The knockout of PB2-S1 has no detectable
CC       effects on laboratory infected mice. {ECO:0000269|PubMed:26491155}.
CC   -!- SUBCELLULAR LOCATION: Host mitochondrion {ECO:0000269|PubMed:26491155}.
CC       Host cytoplasm, host cytosol {ECO:0000269|PubMed:26491155}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=PB2-S1;
CC         IsoId=P0DOG3-1; Sequence=Displayed;
CC       Name=Polymerase basic protein 2;
CC         IsoId=P03427-1; Sequence=External;
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DR   EMBL; J02179; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   SMR; P0DOG3; -.
DR   Proteomes; UP000000834; Genome.
DR   GO; GO:0044164; C:host cell cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   InterPro; IPR001591; INV_PB2.
DR   Pfam; PF00604; Flu_PB2; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Host cytoplasm; Host mitochondrion;
KW   Reference proteome.
FT   CHAIN           1..508
FT                   /note="PB2-S1"
FT                   /id="PRO_0000440601"
SQ   SEQUENCE   508 AA;  57652 MW;  77D23B189BE1AA9E CRC64;
     MERIKELRNL MSQSRTREIL TKTTVDHMAI IKKYTSGRQE KNPALRMKWM MAMKYPITAD
     KRITEMIPER NEQGQTLWSK MNDAGSDRVM VSPLAVTWWN RNGPVTSTVH YPKIYKTYFE
     KVERLKHGTF GPVHFRNQVK IRRRVDINPG HADLSAKEAQ DVIMEVVFPN EVGARILTSE
     SQLTTTKEKK EELQGCKISP LMVAYMLERE LVRKTRFLPV AGGTSSVYIE VLHLTQGTCW
     EQMYTPGGEA RNDDVDQSLI IAARNIVRRA TVSADPLASL LEMCHSTQIG GIRMVNILRQ
     NPTEEQAVDI CKAAMGLRIS SSFSFGGFTF KRTSGSSVKR EEEVLTGNLQ TLKIRVHEGY
     EEFTMVGRRA TAILRKATRR LIQLIVSGRD EQSIAEAIIV AMVFSQEDCM IKAVRGDLNF
     VNRANQRLNP MHQLLRHFQK DAKALFQNWG IESIDNVMGM IGILPDMTPS TEMSMRGVRI
     SKMGVDEYSS AEKIVPLHQS KVECSSPH