ID   PB2S1_I34A1             Reviewed;         510 AA.
AC   P0DOG6;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 1.
DT   07-OCT-2020, entry version 13.
DE   RecName: Full=PB2-S1;
GN   Name=PB2;
OS   Influenza A virus (strain A/Puerto Rico/8/1934 H1N1).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX   NCBI_TaxID=211044;
OH   NCBI_TaxID=8782; Aves.
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=7060132; DOI=10.1016/0092-8674(82)90348-8;
RA   Fields S., Winter G.;
RT   "Nucleotide sequences of influenza virus segments 1 and 3 reveal mosaic
RT   structure of a small viral RNA segment.";
RL   Cell 28:303-313(1982).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=11779399; DOI=10.1098/rstb.2001.0979;
RA   Schickli J.H., Flandorfer A., Nakaya T., Martinez-Sobrido L.,
RA   Garcia-Sastre A., Palese P.;
RT   "Plasmid-only rescue of influenza A virus vaccine candidates.";
RL   Philos. Trans. R. Soc. Lond., B, Biol. Sci. 356:1965-1973(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15163504; DOI=10.1016/j.virusres.2004.02.028;
RA   de Wit E., Spronken M.I.J., Bestebroer T.M., Rimmelzwaan G.F.,
RA   Osterhaus A.D.M.E., Fouchier R.A.M.;
RT   "Efficient generation and growth of influenza virus A/PR/8/34 from eight
RT   cDNA fragments.";
RL   Virus Res. 103:155-161(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Ghedin E., Spiro D., Miller N., Zaborsky J., Feldblyum T., Subbu V.,
RA   Shumway M., Sparenborg J., Groveman L., Halpin R., Sitz J., Koo H.,
RA   Salzberg S.L., Webster R.G., Hoffmann E., Krauss S., Naeve C., Bao Y.,
RA   Bolotov P., Dernovoy D., Kiryutin B., Lipman D.J., Tatusova T.;
RT   "The NIAID influenza genome sequencing project.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May participate in the inhibition of type I interferon
CC       induction through inhibition of the host mitochondrial antiviral
CC       signaling protein MAVS. The knockout of PB2-S1 has no detectable
CC       effects on laboratory infected mice. {ECO:0000250|UniProtKB:P0DOG3}.
CC   -!- SUBCELLULAR LOCATION: Host mitochondrion
CC       {ECO:0000250|UniProtKB:P0DOG3}. Host cytoplasm, host cytosol
CC       {ECO:0000250|UniProtKB:P0DOG3}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=PB2-S1 {ECO:0000250|UniProtKB:P03427};
CC         IsoId=P0DOG6-1; Sequence=Displayed;
CC       Name=Polymerase basic protein 2;
CC         IsoId=P03428-1; Sequence=External;
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DR   EMBL; V00603; -; NOT_ANNOTATED_CDS; Unassigned_RNA.
DR   EMBL; AF389115; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   EMBL; EF467818; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   EMBL; CY009451; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   SMR; P0DOG6; -.
DR   Proteomes; UP000009255; Genome.
DR   Proteomes; UP000116373; Genome.
DR   Proteomes; UP000170967; Genome.
DR   GO; GO:0044164; C:host cell cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   InterPro; IPR001591; INV_PB2.
DR   Pfam; PF00604; Flu_PB2; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Host cytoplasm; Host mitochondrion;
KW   Reference proteome.
FT   CHAIN           1..510
FT                   /note="PB2-S1"
FT                   /id="PRO_0000440604"
SQ   SEQUENCE   510 AA;  58096 MW;  37419FD8D756F653 CRC64;
     MERIKELRNL MSQSRTREIL TKTTVDHMAI IKKYTSGRQE KNPALRMKWM MAMKYPITAD
     KRITEMIPER NEQGQTLWSK MNDAGSDRVM VSPLAVTWWN RNGPITNTVH YPKIYKTYFE
     RVERLKHGTF GPVHFRNQVK IRRRVDINPG HADLSAKEAQ DVIMEVVFPN EVGARILTSE
     SQLTITKEKK EELQDCKISP LMVAYMLERE LVRKTRFLPV AGGTSSVYIE VLHLTQGTCW
     EQMYTPGGEV RNDDVDQSLI IAARNIVRRA AVSADPLASL LEMCHSTQIG GIRMVDILRQ
     NPTEEQAVDI CKAAMGLRIS SSFSFGGFTF KRTSGSSVKR EEEVLTGNLQ TLKIRVHEGY
     EEFTMVGRRA TAILRKATRR LIQLIVSGRD EQSIAEAIIV AMVFSQEDCM IKAVRGDLNF
     VNRANQRLNP MHQLLRHFQK DAKVLFQNWG VEPIDNVMGM IGILPDMTPS IEMSMRGVRI
     SKMGVDEYSS TERVVPLHQS KVECSSPHLL