ID   PB2S1_I49A1             Reviewed;         507 AA.
AC   P0DOG4;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 1.
DT   07-OCT-2020, entry version 23.
DE   RecName: Full=PB2-S1;
GN   Name=PB2;
OS   Influenza A virus (strain A/Duck/Germany/1949 H10N7).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX   NCBI_TaxID=382838;
OH   NCBI_TaxID=8782; Aves.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16439620; DOI=10.1126/science.1121586;
RA   Obenauer J.C., Denson J., Mehta P.K., Su X., Mukatira S., Finkelstein D.B.,
RA   Xu X., Wang J., Ma J., Fan Y., Rakestraw K.M., Webster R.G., Hoffmann E.,
RA   Krauss S., Zheng J., Zhang Z., Naeve C.W.;
RT   "Large-scale sequence analysis of avian influenza isolates.";
RL   Science 311:1576-1580(2006).
CC   -!- FUNCTION: May participate in the inhibition of type I interferon
CC       induction through inhibition of the host mitochondrial antiviral
CC       signaling protein MAVS. The knockout of PB2-S1 has no detectable
CC       effects on laboratory infected mice. {ECO:0000250|UniProtKB:P0DOG3}.
CC   -!- SUBCELLULAR LOCATION: Host mitochondrion
CC       {ECO:0000250|UniProtKB:P0DOG3}. Host cytoplasm, host cytosol
CC       {ECO:0000250|UniProtKB:P0DOG3}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=PB2-S1 {ECO:0000250|UniProtKB:P03427};
CC         IsoId=P0DOG4-1; Sequence=Displayed;
CC       Name=Polymerase basic protein 2;
CC         IsoId=Q0A438-1; Sequence=External;
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DR   EMBL; CY014678; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   SMR; P0DOG4; -.
DR   Proteomes; UP000008217; Genome.
DR   GO; GO:0044164; C:host cell cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   InterPro; IPR001591; INV_PB2.
DR   Pfam; PF00604; Flu_PB2; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Host cytoplasm; Host mitochondrion.
FT   CHAIN           1..507
FT                   /note="PB2-S1"
FT                   /id="PRO_0000440602"
SQ   SEQUENCE   507 AA;  57661 MW;  43A12A8121359EB6 CRC64;
     MERIKELRDL MSQSRTREIL TKTTVDHMAI IKKYTSGRQE KNPALRMKWM MAMKYPITAD
     KRIMEMIPER NEQGQTLWSK TNDAGSDRVM VSPLAVTWWN RNGPTTSTVH YPKVYKPYFE
     KVERLKHGTF GPVHFRNQVK IRRRVDINPG HADLSAKEAQ DVIMEVVFPN EVGARILTSE
     SQLTITKEKK EELQNCKIAP LMVAYMLERE LVRKTRFLPV AGGTSSVYIE VLHLTQGTCW
     EQMYTPGGEV RNDDVDQSLI IAARNIVRRA TVSADPLASL LEMCHSTQIG GIRMVDILRQ
     NPTEEQAVDI CKAAMGLRIS SSFSFGGFTF KRTSGSSVKR EEEVLTGNLQ TLKIRVHEGY
     EEFTMVGRRA TAILRKATRR LIQLIVSGRD EQSIAEAIIV AMVFSQEDCM IKAVRGDLNF
     VNRANQRLNP MHQLLRHFQK DAKVLFQNWG IEPIDNVMGM IGILPDMTPS TEMSLRGVRV
     SKMGVDEYSS TERVQPHRSR VGCSSLL