ID   PB2S1_I96A0             Reviewed;         508 AA.
AC   P0DOG5;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 1.
DT   07-OCT-2020, entry version 13.
DE   RecName: Full=PB2-S1;
GN   Name=PB2;
OS   Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX   NCBI_TaxID=93838;
OH   NCBI_TaxID=8782; Aves.
OH   NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9691; Panthera pardus (Leopard) (Felis pardus).
OH   NCBI_TaxID=9694; Panthera tigris (Tiger).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=10484749; DOI=10.1006/viro.1999.9820;
RA   Xu X., Subbarao K., Cox N.J., Guo Y.;
RT   "Genetic characterization of the pathogenic influenza
RT   A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene
RT   to those of H5N1 viruses from the 1997 outbreaks in Hong Kong.";
RL   Virology 261:15-19(1999).
CC   -!- FUNCTION: May participate in the inhibition of type I interferon
CC       induction through inhibition of the host mitochondrial antiviral
CC       signaling protein MAVS. The knockout of PB2-S1 has no detectable
CC       effects on laboratory infected mice. {ECO:0000250|UniProtKB:P0DOG3}.
CC   -!- SUBCELLULAR LOCATION: Host mitochondrion
CC       {ECO:0000250|UniProtKB:P0DOG3}. Host cytoplasm, host cytosol
CC       {ECO:0000250|UniProtKB:P0DOG3}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=PB2-S1 {ECO:0000250|UniProtKB:P03427};
CC         IsoId=P0DOG5-1; Sequence=Displayed;
CC       Name=Polymerase basic protein 2;
CC         IsoId=Q9Q0V1-1; Sequence=External;
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DR   EMBL; AF144300; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   SMR; P0DOG5; -.
DR   Proteomes; UP000131152; Genome.
DR   GO; GO:0044164; C:host cell cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   InterPro; IPR001591; INV_PB2.
DR   Pfam; PF00604; Flu_PB2; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Host cytoplasm; Host mitochondrion;
KW   Reference proteome.
FT   CHAIN           1..508
FT                   /note="PB2-S1"
FT                   /id="PRO_0000440603"
SQ   SEQUENCE   508 AA;  57810 MW;  BB5FDC23FC7B5C25 CRC64;
     MERIKELRDL MSQSRTREIL TKTTVDHMAI IKKYTSGRQE KNPALRMKWM MAMKYPITAD
     KRIMEMIPER NEQGQTLWSK TNDAGSDRVM VSPLAVTWWN RNGPTTSTVH YPKVYKTYFE
     KVERLKHGTF GPVHFRNQVK IRRRVDINPG HADLSAKEAQ DVIMEVVFPN EVGARILTSE
     SQLTITKEKK EELQDCKIAP LMVAYMLERE LVRKTRFLPV AGGTSSVYIE VLHLTQGTCW
     EQMYTPGGEV RNDDVDQSLI IAARNIVRRA TVSADPLASL LEMCHSTQIG GIRMVDILRQ
     NPTEEQAVDI CKAAMGLRIS SSFSFGGFTF KRTNGSSVKK EEEVLTGNLQ TLKIKVHEGY
     EEFTMVGRRA TAILRKATRR LIQLIVSGRD EQSIAEAIIV AMVFSQEDCM IKAVRGDLNF
     VNRANQRLNP MHQLLRHFQK DAKVLFQNWG IEPIDNVMGM IGILPDMTPS AEMSLRGVRV
     SKMGVDEYSS TERVVQPHRS RAECSFLL