PB2_I82A2
ID PB2_I82A2 Reviewed; 126 AA.
AC P26146;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 23-FEB-2022, entry version 77.
DE RecName: Full=Polymerase basic protein 2;
DE AltName: Full=RNA-directed RNA polymerase subunit P3;
DE Flags: Fragment;
GN Name=PB2;
OS Influenza A virus (strain A/Camel/Mongolia/1982 H1N1).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX NCBI_TaxID=387191;
OH NCBI_TaxID=8782; Aves.
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8249279; DOI=10.1006/viro.1993.1629;
RA Yamnikova S.S., Mandler J., Bekh-Ochir Z.H., Dachtzeren P., Ludwig S.,
RA Lvov D.K., Scholtissek C.;
RT "A reassortant H1N1 influenza A virus caused fatal epizootics among camels
RT in Mongolia.";
RL Virology 197:558-563(1993).
CC -!- FUNCTION: Plays an essential role in transcription initiation and cap-
CC stealing mechanism, in which cellular capped pre-mRNAs are used to
CC generate primers for viral transcription. Binds the cap of the target
CC pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA.
CC Plays a role in the initiation of the viral genome replication and
CC modulates the activity of the ribonucleoprotein (RNP) complex. In
CC addition, participates in the inhibition of type I interferon induction
CC through interaction with the host mitochondrial antiviral signaling
CC protein MAVS. {ECO:0000250|UniProtKB:P03428}.
CC -!- SUBUNIT: Influenza RNA polymerase is composed of three subunits: PB1,
CC PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus).
CC Interacts with nucleoprotein NP (via N-terminus). Interacts (via N-
CC terminus) with host MAVS (via N-terminus); this interaction inhibits
CC host innate immune response. {ECO:0000250|UniProtKB:P03428}.
CC -!- SUBCELLULAR LOCATION: Virion. Host nucleus
CC {ECO:0000250|UniProtKB:P03428}. Host mitochondrion
CC {ECO:0000250|UniProtKB:P03428}.
CC -!- SIMILARITY: Belongs to the influenza viruses PB2 family. {ECO:0000305}.
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DR EMBL; M73972; AAA16911.2; -; mRNA.
DR GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006370; P:7-methylguanosine mRNA capping; IEA:UniProtKB-KW.
DR GO; GO:0075526; P:cap snatching; IEA:UniProtKB-KW.
DR GO; GO:0039523; P:suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity; IEA:UniProtKB-KW.
DR GO; GO:0039545; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR InterPro; IPR001591; INV_PB2.
DR Pfam; PF00604; Flu_PB2; 1.
PE 2: Evidence at transcript level;
KW Cap snatching; Eukaryotic host gene expression shutoff by virus;
KW Eukaryotic host transcription shutoff by virus;
KW Host gene expression shutoff by virus; Host mitochondrion; Host nucleus;
KW Host-virus interaction; Inhibition of host innate immune response by virus;
KW Inhibition of host MAVS by virus; Inhibition of host RLR pathway by virus;
KW Inhibition of host RNA polymerase II by virus; mRNA capping;
KW mRNA processing; Viral immunoevasion; Viral transcription; Virion.
FT CHAIN <1..>126
FT /note="Polymerase basic protein 2"
FT /id="PRO_0000078814"
FT NON_TER 1
FT NON_TER 126
SQ SEQUENCE 126 AA; 14561 MW; 68421114F8570568 CRC64;
RITEMIPERN EQGQTLWSKM NDAGSDRVMV SPLAVTWWNR NGPITNTVHY PKIYKTYFER
VERLKHGTFG PVHFRNQVKI RRRVDINPGH ADLSAKEAQD VIMEVVFPNE VGARILTSES
QLTITK
