ID   PB2_ISAV8               Reviewed;         722 AA.
AC   Q6UBL8;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Polymerase basic protein 2;
DE            Short=PB2;
DE   AltName: Full=Protein 3;
DE            Short=P3;
DE   AltName: Full=RNA-directed RNA polymerase subunit P3;
GN   Name=Segment-1 {ECO:0000303|PubMed:20979983};
OS   Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99)
OS   (ISAV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Isavirus.
OX   NCBI_TaxID=652965;
OH   NCBI_TaxID=8049; Gadus morhua (Atlantic cod).
OH   NCBI_TaxID=8019; Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
OH   NCBI_TaxID=8022; Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OH   NCBI_TaxID=8060; Pollachius virens (Saithe) (Gadus virens).
OH   NCBI_TaxID=8030; Salmo salar (Atlantic salmon).
OH   NCBI_TaxID=8032; Salmo trutta (Brown trout).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Kibenge F.S., Qian B., Kibenge M.J.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=12606081; DOI=10.1016/s0168-1702(02)00322-2;
RA   Snow M., Ritchie R., Arnaud O., Villoing S., Aspehaug V., Cunningham C.O.;
RT   "Isolation and characterisation of segment 1 of the infectious salmon
RT   anaemia virus genome.";
RL   Virus Res. 92:99-105(2003).
RN   [3]
RP   REVIEW.
RX   PubMed=20979983; DOI=10.1016/j.virusres.2010.10.021;
RA   Cottet L., Rivas-Aravena A., Cortez-San Martin M., Sandino A.M.,
RA   Spencer E.;
RT   "Infectious salmon anemia virus--genetics and pathogenesis.";
RL   Virus Res. 155:10-19(2011).
CC   -!- FUNCTION: Involved in transcription initiation and cap-stealing
CC       mechanism, in which cellular capped pre-mRNA are used to generate
CC       primers for viral transcription. Binds the cap of the target pre-RNA
CC       which is subsequently cleaved by PB1. May play a role in genome
CC       replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The RNA polymerase is composed of three subunits: PB1, PB2 and
CC       PA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host nucleus
CC       {ECO:0000269|PubMed:12606081}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY373381; AAQ81914.1; -; mRNA.
DR   RefSeq; YP_145807.1; NC_006505.1.
DR   PRIDE; Q6UBL8; -.
DR   GeneID; 3170818; -.
DR   KEGG; vg:3170818; -.
DR   Proteomes; UP000008772; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host nucleus; Reference proteome; Virion.
FT   CHAIN           1..722
FT                   /note="Polymerase basic protein 2"
FT                   /id="PRO_0000403917"
SQ   SEQUENCE   722 AA;  79918 MW;  DAB5408D3035ECD0 CRC64;
     MDFISENTIS DKTTLEELKN ATLFQVTKVD DRDCLRARRI CNAPKGHWAG LMEKAKAMGD
     PTEEEKDELK KIVESYNTVS VLGVSKSEGA TGPRLVSSLK GLKNLLPGVN PKTLQETLLV
     GAPCPSTEPT TEEYWNVCRA AVGASMGSAK INMSQKVVMG ASVIGWGQLN QSGPGVYFLN
     TKEIVTAEGK VDETRGPLER TSAPLMRDIS RLIQETIEEV ETGGDPSFSV RSEGGSKIEG
     RIAFSLHSEV STLKMRIALE QKLAKYEYMG ENLLTLVKNT SIDRMQPDSA MMGKMVLESL
     RTHTVSSEQL NGRMITVQSQ GLETIAISSP FDVEYDDGYV FTRMKGNFVA VGRDYKGAIL
     CFREGQGTFF SGRGNWSGLM EKCLVEMRLC PCFYSCTWQD YPDKKSLYEK ATFEAKQIVF
     AMGENTGVDI RVNTDGEIGD KGISLLTRER EDKYMSKVSY ECRVVSGKLV MGLDKMSRVA
     KGNLEVVREK GDDTSQSDSF YEGVLQVGSM IGTTMESLKQ QLQGPVGIWR ASGVSAMERC
     MKRGQSKTVV ASARYTFQKM MEKMATGREV SKYSLIIVMR CCIGFTSEAN KRALTNISGT
     GYYISVAQPT VVKLAGEWLI TPVGRSKTGE VQYVSAKLKK GMTTGKLELI KKADRSDLDN
     FPEPSADELL REGTIVLMQI GKDKWLCRVR TGDRRVRTDT DIQRAEAKSQ VEKEDLMDEY
     GV