PBAN_AEDAE
ID PBAN_AEDAE Reviewed; 171 AA.
AC Q16N80;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 62.
DE RecName: Full=PBAN-type neuropeptides;
DE AltName: Full=Pheromone/pyrokinin biosynthesis-activating neuropeptide;
DE Contains:
DE RecName: Full=AAAMWFGPRL-amide;
DE AltName: Full=Pyrokinin-1;
DE Contains:
DE RecName: Full=QPQPVFYHSTTPRL-amide;
DE Contains:
DE RecName: Full=DASSSNENNSRPPFAPRL-amide;
DE AltName: Full=Pyrokinin-2;
DE Contains:
DE RecName: Full=NLPFSPRL-amide;
DE AltName: Full=Pyrokinin-3;
DE Flags: Precursor;
GN Name=PBAN {ECO:0000250|UniProtKB:A8CL69}; ORFNames=AAEL012060;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1] {ECO:0000312|EMBL:EAT35796.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: A hormone that controls sex pheromone production in females
CC and pheromone responsiveness in male. Also mediates visceral muscle
CC contractile activity (myotropic activity) (By similarity).
CC {ECO:0000250|UniProtKB:A8CL69, ECO:0000250|UniProtKB:P09971}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:A8CL69}.
CC -!- SIMILARITY: Belongs to the pyrokinin family. {ECO:0000255}.
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DR EMBL; CH477835; EAT35796.1; -; Genomic_DNA.
DR RefSeq; XP_001662212.1; XM_001662162.1.
DR AlphaFoldDB; Q16N80; -.
DR STRING; 7159.AAEL012060-PA; -.
DR GeneID; 5575794; -.
DR KEGG; aag:5575794; -.
DR VEuPathDB; VectorBase:AAEL012060; -.
DR eggNOG; ENOG502R349; Eukaryota.
DR HOGENOM; CLU_1541633_0_0_1; -.
DR InParanoid; Q16N80; -.
DR OMA; QPVFYHS; -.
DR OrthoDB; 1434163at2759; -.
DR PhylomeDB; Q16N80; -.
DR Proteomes; UP000008820; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0016084; F:myostimulatory hormone activity; ISS:UniProtKB.
DR GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
DR GO; GO:0042811; P:pheromone biosynthetic process; IEA:InterPro.
DR InterPro; IPR008730; PBAN.
DR InterPro; IPR001484; Pyrokinin_CS.
DR Pfam; PF05874; PBAN; 1.
DR PROSITE; PS00539; PYROKININ; 2.
PE 3: Inferred from homology;
KW Amidation; Cleavage on pair of basic residues; Hormone; Neuropeptide;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..47
FT /evidence="ECO:0000250|UniProtKB:A8CL69, ECO:0000255"
FT /id="PRO_0000339251"
FT PEPTIDE 50..59
FT /note="AAAMWFGPRL-amide"
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
FT /id="PRO_0000339252"
FT PROPEP 63..111
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
FT /id="PRO_0000339253"
FT PEPTIDE 113..126
FT /note="QPQPVFYHSTTPRL-amide"
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
FT /id="PRO_0000339254"
FT PEPTIDE 130..147
FT /note="DASSSNENNSRPPFAPRL-amide"
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
FT /id="PRO_0000339255"
FT PEPTIDE 150..157
FT /note="NLPFSPRL-amide"
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
FT /id="PRO_0000339256"
FT PROPEP 160..171
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
FT /id="PRO_0000339257"
FT REGION 120..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 59
FT /note="Leucine amide"
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
FT MOD_RES 126
FT /note="Leucine amide"
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
FT MOD_RES 147
FT /note="Leucine amide"
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
FT MOD_RES 157
FT /note="Leucine amide"
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
SQ SEQUENCE 171 AA; 19176 MW; B063018DC5D9EACB CRC64;
MFRLYFFFNV ICIFLAIRSA IGGEVPDATE QKINNFLASG KDSEDLSKRA AAMWFGPRLG
KRTIASELHD EMMDEIDDNP LYYSGESPQR VASEIAQGTP YVVLLLTGRV LRQPQPVFYH
STTPRLGRRD ASSSNENNSR PPFAPRLGRN LPFSPRLGRS FGAPVVDNFA Y
