PBAN_ANOGA
ID PBAN_ANOGA Reviewed; 187 AA.
AC Q7PTL2;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 2.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=PBAN-type neuropeptides;
DE AltName: Full=Pheromone/pyrokinin biosynthesis-activating neuropeptide;
DE Contains:
DE RecName: Full=AAAMWFGPRL-amide;
DE AltName: Full=Pyrokinin-1;
DE Contains:
DE RecName: Full=PQPIFYHTTSPRL-amide;
DE Contains:
DE RecName: Full=DSVGENHQRPPFAPRL-amide;
DE AltName: Full=Pyrokinin-2;
DE Contains:
DE RecName: Full=NLPFSPRL-amide;
DE AltName: Full=Pyrokinin-3;
DE Flags: Precursor;
GN Name=PBAN {ECO:0000250|UniProtKB:A8CL69};
GN Synonyms=PKP {ECO:0000312|EMBL:EAA03729.3}; ORFNames=AGAP002292;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1] {ECO:0000312|EMBL:EAA03729.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: A hormone that controls sex pheromone production in females
CC and pheromone responsiveness in male. Also mediates visceral muscle
CC contractile activity (myotropic activity) (By similarity).
CC {ECO:0000250|UniProtKB:A8CL69, ECO:0000250|UniProtKB:P09971}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:A8CL69}.
CC -!- SIMILARITY: Belongs to the pyrokinin family. {ECO:0000255}.
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DR EMBL; AAAB01008799; EAA03729.3; -; Genomic_DNA.
DR RefSeq; XP_307885.2; XM_307885.4.
DR AlphaFoldDB; Q7PTL2; -.
DR SMR; Q7PTL2; -.
DR STRING; 7165.AGAP002292-PA; -.
DR PaxDb; Q7PTL2; -.
DR GeneID; 1269266; -.
DR KEGG; aga:AgaP_AGAP002292; -.
DR CTD; 1269266; -.
DR VEuPathDB; VectorBase:AGAP002292; -.
DR eggNOG; ENOG502R349; Eukaryota.
DR HOGENOM; CLU_1541633_0_0_1; -.
DR InParanoid; Q7PTL2; -.
DR OMA; QPVFYHS; -.
DR OrthoDB; 1434163at2759; -.
DR PhylomeDB; Q7PTL2; -.
DR Proteomes; UP000007062; Chromosome 2R.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0016084; F:myostimulatory hormone activity; ISS:UniProtKB.
DR GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
DR InterPro; IPR001484; Pyrokinin_CS.
DR PROSITE; PS00539; PYROKININ; 2.
PE 3: Inferred from homology;
KW Amidation; Cleavage on pair of basic residues; Hormone; Neuropeptide;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..64
FT /evidence="ECO:0000250|UniProtKB:A8CL69, ECO:0000255"
FT /id="PRO_0000339258"
FT PEPTIDE 67..76
FT /note="AAAMWFGPRL-amide"
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
FT /id="PRO_0000339259"
FT PROPEP 80..127
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
FT /id="PRO_0000339260"
FT PEPTIDE 130..142
FT /note="PQPIFYHTTSPRL-amide"
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
FT /id="PRO_0000339261"
FT PEPTIDE 146..161
FT /note="DSVGENHQRPPFAPRL-amide"
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
FT /id="PRO_0000339262"
FT PEPTIDE 164..171
FT /note="NLPFSPRL-amide"
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
FT /id="PRO_0000339263"
FT PROPEP 174..187
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
FT /id="PRO_0000339264"
FT REGION 34..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 76
FT /note="Leucine amide"
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
FT MOD_RES 142
FT /note="Leucine amide"
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
FT MOD_RES 161
FT /note="Leucine amide"
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
FT MOD_RES 171
FT /note="Leucine amide"
FT /evidence="ECO:0000250|UniProtKB:A8CL69"
SQ SEQUENCE 187 AA; 20940 MW; 3FD7FF2B2163D456 CRC64;
MSRFYFFFNL ICLYLAIKSA LSAELDTNDQ KYADLRTTGR GESPDSTGPD SDTLRRDDGA
EGLNKRAAAM WFGPRLGKRT IAADLHDDLV EEFDAEPLGY AGEPPQKLAT ELVQGAPYMV
LLVTAKPRKP QPIFYHTTSP RLGRRDSVGE NHQRPPFAPR LGRNLPFSPR LGRSYNGGYP
LPFQFAY
