ID   PBAN_HELAU              Reviewed;         194 AA.
AC   O18641; Q95P22;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=PBAN-type neuropeptides;
DE   AltName: Full=Pheromone/pyrokinin biosynthesis-activating neuropeptide;
DE   Contains:
DE     RecName: Full=Diapause hormone homolog;
DE              Short=DH;
DE     AltName: Full=Pyrokinin-1;
DE   Contains:
DE     RecName: Full=Alpha-SG neuropeptide;
DE   Contains:
DE     RecName: Full=Beta-SG neuropeptide;
DE     AltName: Full=Pyrokinin-2;
DE   Contains:
DE     RecName: Full=Pheromone biosynthesis-activating neuropeptide;
DE              Short=Has-PBAN;
DE              Short=HeA-PBAN;
DE     AltName: Full=Pyrokinin-3;
DE   Contains:
DE     RecName: Full=Gamma-SG neuropeptide;
DE     AltName: Full=Pyrokinin-4;
DE   Flags: Precursor;
GN   Name=PBAN;
OS   Helicoverpa assulta (Oriental tobacco budworm) (Heliothis assulta).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Heliothinae; Helicoverpa.
OX   NCBI_TaxID=52344;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, DEVELOPMENTAL STAGE, AND PEPTIDE SYNTHESIS.
RC   TISSUE=Brain, and Subesophageal ganglion;
RX   PubMed=9807222; DOI=10.1016/s0965-1748(98)00065-4;
RA   Choi M.Y., Tanaka M., Kataoka H., Boo K.S., Tatsuki S.;
RT   "Isolation and identification of the cDNA encoding the pheromone
RT   biosynthesis activating neuropeptide and additional neuropeptides in the
RT   oriental tobacco budworm, Helicoverpa assulta (Lepidoptera: Noctuidae).";
RL   Insect Biochem. Mol. Biol. 28:759-766(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Subesophageal ganglion;
RA   Tang Q., Yang X., An S., Jiu M., Guo X., Ma J.;
RT   "cDNA cloning and sequence determination of the diapause hormone
RT   neuropeptide of the oriental to tobacco budworm, Helicoverpa assulta.";
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: A hormone that controls sex pheromone production in females
CC       and pheromone responsiveness in male. Also mediates visceral muscle
CC       contractile activity (myotropic activity).
CC       {ECO:0000269|PubMed:9807222}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9807222}.
CC   -!- TISSUE SPECIFICITY: Synthesized in the subesophageal ganglion and
CC       released in the hemolymph. {ECO:0000269|PubMed:9807222}.
CC   -!- DEVELOPMENTAL STAGE: Detected in 1-3 day old adults.
CC       {ECO:0000269|PubMed:9807222}.
CC   -!- MISCELLANEOUS: Juvenile hormone seems to allow PBAN release, which then
CC       induces pheromone biosynthesis. {ECO:0000250}.
CC   -!- MISCELLANEOUS: PBAN is produced independent of the photoperiod. The
CC       circadian rhythm in pheromone production is due to the circadian rhythm
CC       of PBAN release.
CC   -!- SIMILARITY: Belongs to the pyrokinin family. {ECO:0000305}.
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DR   EMBL; U96761; AAC64293.1; -; mRNA.
DR   EMBL; AY052417; AAL13079.2; -; mRNA.
DR   AlphaFoldDB; O18641; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0042811; P:pheromone biosynthetic process; IEA:InterPro.
DR   GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR   InterPro; IPR008730; PBAN.
DR   InterPro; IPR001484; Pyrokinin_CS.
DR   Pfam; PF05874; PBAN; 1.
DR   PROSITE; PS00539; PYROKININ; 4.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Neuropeptide;
KW   Pheromone response; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         24..47
FT                   /note="Diapause hormone homolog"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000029929"
FT   PROPEP          51..94
FT                   /id="PRO_0000029930"
FT   PEPTIDE         97..103
FT                   /note="Alpha-SG neuropeptide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000029931"
FT   PEPTIDE         106..123
FT                   /note="Beta-SG neuropeptide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000029932"
FT   PEPTIDE         127..159
FT                   /note="Pheromone biosynthesis-activating neuropeptide"
FT                   /id="PRO_0000029933"
FT   PEPTIDE         162..169
FT                   /note="Gamma-SG neuropeptide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000029934"
FT   PROPEP          172..194
FT                   /id="PRO_0000029935"
FT   MOD_RES         47
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         103
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         123
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         159
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         169
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   194 AA;  22343 MW;  392AB211375A474D CRC64;
     MFNQTQFFVL LAVFTTSSVL GNNNDVKDGA ASGAHSDRLG LWFGPRLGKR SLRISTEDNR
     QAFFKLLEAA DALKYYYDQL PYEMQADEPE TRVTKKVIFT PKLGRSLAYD DKSFENVEFT
     PRLGRRLSDD MPATPADQEM YRQDPEQIDS RTKYFSPRLG RTMNFSPRLG RELSYDMMPN
     KIRVVRSANK TRST