PBAN_HELIE
ID PBAN_HELIE Reviewed; 194 AA.
AC C0HL17;
DT 22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2017, sequence version 1.
DT 25-MAY-2022, entry version 7.
DE RecName: Full=PBAN-type neuropeptides {ECO:0000303|PubMed:28502715};
DE Contains:
DE RecName: Full=Diapause hormone {ECO:0000303|PubMed:28502715};
DE AltName: Full=trypto-pyrokinin {ECO:0000303|PubMed:28502715};
DE Short=tryptoPK {ECO:0000303|PubMed:28502715};
DE Contains:
DE RecName: Full=Alpha-subesophageal ganglion neuropeptide {ECO:0000303|PubMed:28502715};
DE Short=Alpha-SG neuropeptide;
DE Short=Alpha-SGNP {ECO:0000303|PubMed:28502715};
DE AltName: Full=Pyrokinin-1 {ECO:0000303|PubMed:28502715};
DE Short=PK-1 {ECO:0000303|PubMed:28502715};
DE Contains:
DE RecName: Full=Beta-subesophageal ganglion neuropeptide {ECO:0000303|PubMed:28502715};
DE Short=Beta-SG neuropeptide;
DE Short=Beta-SGNP {ECO:0000303|PubMed:28502715};
DE AltName: Full=Pyrokinin-2 {ECO:0000303|PubMed:28502715};
DE Short=PK-2 {ECO:0000303|PubMed:28502715};
DE Contains:
DE RecName: Full=Pheromone biosynthesis-activating neuropeptide {ECO:0000303|PubMed:28502715};
DE Short=PBAN;
DE AltName: Full=Pyrokinin-3 {ECO:0000303|PubMed:28502715};
DE Short=PK-3 {ECO:0000303|PubMed:28502715};
DE Contains:
DE RecName: Full=Gamma-subesophageal ganglion neuropeptide {ECO:0000303|PubMed:28502715};
DE Short=Gamma-SG neuropeptide;
DE Short=Gamma-SGNP {ECO:0000303|PubMed:28502715};
DE AltName: Full=Pyrokinin-4 {ECO:0000303|PubMed:28502715};
DE Short=PK-4 {ECO:0000303|PubMed:28502715};
DE Flags: Precursor;
OS Heliothis peltigera (Bordered straw moth) (Noctua peltigera).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Heliothis.
OX NCBI_TaxID=542982 {ECO:0000303|PubMed:28502715};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-47; 97-103; 106-123;
RP 127-159 AND 162-169, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MASS
RP SPECTROMETRY, AMIDATION AT LEU-47; LEU-103; LEU-123; LEU-159 AND LEU-169,
RP AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Nervous system {ECO:0000303|PubMed:28502715};
RX PubMed=28502715; DOI=10.1016/j.peptides.2017.05.004;
RA Ragionieri L., Oezbagci B., Neupert S., Salts Y., Davidovitch M.,
RA Altstein M., Predel R.;
RT "Identification of mature peptides from pban and capa genes of the moths
RT Heliothis peltigera and Spodoptera littoralis.";
RL Peptides 94:1-9(2017).
CC -!- FUNCTION: A hormone that controls sex pheromone production in females
CC and pheromone responsiveness in male. {ECO:0000250|UniProtKB:P09971}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the subesophageal ganglion.
CC {ECO:0000269|PubMed:28502715}.
CC -!- DEVELOPMENTAL STAGE: Detected in both larvae and adults.
CC {ECO:0000269|PubMed:28502715}.
CC -!- MASS SPECTROMETRY: [Diapause hormone]: Mass=2823.38; Method=MALDI;
CC Note=Diapause hormone.; Evidence={ECO:0000269|PubMed:28502715};
CC -!- MASS SPECTROMETRY: [Alpha-subesophageal ganglion neuropeptide]:
CC Mass=816.53; Method=MALDI; Note=Alpha-subesophageal ganglion
CC neuropeptide.; Evidence={ECO:0000269|PubMed:28502715};
CC -!- MASS SPECTROMETRY: [Beta-subesophageal ganglion neuropeptide]:
CC Mass=2144.07; Method=MALDI; Note=Beta-subesophageal ganglion
CC neuropeptide.; Evidence={ECO:0000269|PubMed:28502715};
CC -!- MASS SPECTROMETRY: [Pheromone biosynthesis-activating neuropeptide]:
CC Mass=3865.88; Method=MALDI; Note=Pheromone biosynthesis-activating
CC neuropeptide.; Evidence={ECO:0000269|PubMed:28502715};
CC -!- MASS SPECTROMETRY: [Gamma-subesophageal ganglion neuropeptide]:
CC Mass=964.50; Method=MALDI; Note=Gamma-subesophageal ganglion
CC neuropeptide.; Evidence={ECO:0000269|PubMed:28502715};
CC -!- SIMILARITY: Belongs to the pyrokinin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; C0HL17; -.
DR SMR; C0HL17; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0042811; P:pheromone biosynthetic process; IEA:InterPro.
DR InterPro; IPR008730; PBAN.
DR InterPro; IPR001484; Pyrokinin_CS.
DR Pfam; PF05874; PBAN; 1.
DR PROSITE; PS00539; PYROKININ; 4.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Hormone; Neuropeptide; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PEPTIDE 22..47
FT /note="Diapause hormone"
FT /evidence="ECO:0000269|PubMed:28502715"
FT /id="PRO_0000442326"
FT PROPEP 51..94
FT /evidence="ECO:0000305|PubMed:28502715"
FT /id="PRO_0000442327"
FT PEPTIDE 97..103
FT /note="Alpha-subesophageal ganglion neuropeptide"
FT /evidence="ECO:0000269|PubMed:28502715"
FT /id="PRO_0000442328"
FT PEPTIDE 106..123
FT /note="Beta-subesophageal ganglion neuropeptide"
FT /evidence="ECO:0000269|PubMed:28502715"
FT /id="PRO_0000442329"
FT PEPTIDE 127..159
FT /note="Pheromone biosynthesis-activating neuropeptide"
FT /evidence="ECO:0000269|PubMed:28502715"
FT /id="PRO_0000442330"
FT PEPTIDE 162..169
FT /note="Gamma-subesophageal ganglion neuropeptide"
FT /evidence="ECO:0000269|PubMed:28502715"
FT /id="PRO_0000442331"
FT PROPEP 172..194
FT /evidence="ECO:0000305|PubMed:28502715"
FT /id="PRO_0000442332"
FT MOD_RES 47
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:28502715"
FT MOD_RES 103
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:28502715"
FT MOD_RES 123
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:28502715"
FT MOD_RES 159
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:28502715"
FT MOD_RES 169
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:28502715"
SQ SEQUENCE 194 AA; 22360 MW; 71481ECD13AFA043 CRC64;
MYVQRKCLFL LAVFTISSVS GNNNDVKDGA DRGAHSDRGG LWFGPRLGKR SLRIATEDNR
QAFFKLLEAA DALKYYYDQL PYEMQADEPE TRVTKKVIFT PKLGRSIAYE DKSFENVEFT
PRLGRRLADD MPATPADQEI YRQDPEQIDS RTKYFSPRLG RTMNFSPRLG RELSYDMLPN
KIRVARSTNK TRST
