PBAN_SPOLI
ID PBAN_SPOLI Reviewed; 191 AA.
AC Q95P48;
DT 22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 53.
DE RecName: Full=PBAN-type neuropeptides {ECO:0000303|PubMed:28502715};
DE Contains:
DE RecName: Full=Diapause hormone {ECO:0000303|PubMed:28502715};
DE Short=DH {ECO:0000303|PubMed:28502715};
DE AltName: Full=trypto-pyrokinin {ECO:0000303|PubMed:28502715};
DE Short=tryptoPK {ECO:0000303|PubMed:28502715};
DE Contains:
DE RecName: Full=Alpha-subesophageal ganglion neuropeptide {ECO:0000303|PubMed:28502715};
DE Short=Alpha-SG neuropeptide;
DE Short=Alpha-SGNP {ECO:0000303|PubMed:28502715};
DE AltName: Full=Pyrokinin-1 {ECO:0000303|PubMed:28502715};
DE Short=PK-1 {ECO:0000303|PubMed:28502715};
DE Contains:
DE RecName: Full=Beta-subesophageal ganglion neuropeptide {ECO:0000303|PubMed:28502715};
DE Short=Beta-SG neuropeptide;
DE Short=Beta-SGNP {ECO:0000303|PubMed:28502715};
DE AltName: Full=Pyrokinin-2 {ECO:0000303|PubMed:28502715};
DE Short=PK-2 {ECO:0000303|PubMed:28502715};
DE Contains:
DE RecName: Full=Pheromone biosynthesis-activating neuropeptide {ECO:0000303|PubMed:28502715};
DE Short=PBAN;
DE AltName: Full=Pyrokinin-3 {ECO:0000303|PubMed:28502715};
DE Short=PK-3 {ECO:0000303|PubMed:28502715};
DE Contains:
DE RecName: Full=Gamma-subesophageal ganglion neuropeptide {ECO:0000303|PubMed:28502715};
DE Short=Gamma-SG neuropeptide;
DE Short=Gamma-SGNP {ECO:0000303|PubMed:28502715};
DE AltName: Full=Pyrokinin-4 {ECO:0000303|PubMed:28502715};
DE Short=PK-4 {ECO:0000303|PubMed:28502715};
DE Flags: Precursor;
OS Spodoptera littoralis (Egyptian cotton leafworm).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Amphipyrinae; Spodoptera.
OX NCBI_TaxID=7109 {ECO:0000312|EMBL:AAK84160.1};
RN [1] {ECO:0000312|EMBL:AAK84160.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain {ECO:0000312|EMBL:AAK84160.1};
RX PubMed=12110297; DOI=10.1016/s0965-1748(01)00179-5;
RA Iglesias F., Marco P., Francois M.C., Camps F., Fabrias G.,
RA Jacquin-Joly E.;
RT "A new member of the PBAN family in Spodoptera littoralis: molecular
RT cloning and immunovisualisation in scotophase hemolymph.";
RL Insect Biochem. Mol. Biol. 32:901-908(2002).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 18-44; 94-100; 103-120;
RP 124-156 AND 159-166, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MASS
RP SPECTROMETRY, AMIDATION AT LEU-44; LEU-100; LEU-120; LEU-156 AND LEU-166,
RP AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Nervous system {ECO:0000303|PubMed:28502715};
RX PubMed=28502715; DOI=10.1016/j.peptides.2017.05.004;
RA Ragionieri L., Oezbagci B., Neupert S., Salts Y., Davidovitch M.,
RA Altstein M., Predel R.;
RT "Identification of mature peptides from pban and capa genes of the moths
RT Heliothis peltigera and Spodoptera littoralis.";
RL Peptides 94:1-9(2017).
CC -!- FUNCTION: A hormone that controls sex pheromone production in females
CC and pheromone responsiveness in male. {ECO:0000250|UniProtKB:P09971}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P09971}.
CC -!- TISSUE SPECIFICITY: Expressed in the subesophageal ganglion.
CC {ECO:0000269|PubMed:28502715}.
CC -!- DEVELOPMENTAL STAGE: Detected in both larvae and adults.
CC {ECO:0000269|PubMed:28502715}.
CC -!- MASS SPECTROMETRY: [Diapause hormone]: Mass=2911.43; Method=MALDI;
CC Note=Diapause hormone.; Evidence={ECO:0000269|PubMed:28502715};
CC -!- MASS SPECTROMETRY: [Alpha-subesophageal ganglion neuropeptide]:
CC Mass=816.53; Method=MALDI; Note=Alpha-subesophageal ganglion
CC neuropeptide.; Evidence={ECO:0000269|PubMed:28502715};
CC -!- MASS SPECTROMETRY: [Beta-subesophageal ganglion neuropeptide]:
CC Mass=2142.09; Method=MALDI; Note=Beta-subesophageal ganglion
CC neuropeptide.; Evidence={ECO:0000269|PubMed:28502715};
CC -!- MASS SPECTROMETRY: [Pheromone biosynthesis-activating neuropeptide]:
CC Mass=3820.86; Method=MALDI; Note=Pheromone biosynthesis-activating
CC neuropeptide.; Evidence={ECO:0000269|PubMed:28502715};
CC -!- MASS SPECTROMETRY: [Gamma-subesophageal ganglion neuropeptide]:
CC Mass=964.50; Method=MALDI; Note=Gamma-subesophageal ganglion
CC neuropeptide.; Evidence={ECO:0000269|PubMed:28502715};
CC -!- SIMILARITY: Belongs to the pyrokinin family. {ECO:0000255}.
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DR EMBL; AF401480; AAK84160.1; -; mRNA.
DR AlphaFoldDB; Q95P48; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0042811; P:pheromone biosynthetic process; IEA:InterPro.
DR InterPro; IPR008730; PBAN.
DR InterPro; IPR001484; Pyrokinin_CS.
DR Pfam; PF05874; PBAN; 1.
DR PROSITE; PS00539; PYROKININ; 4.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Hormone; Neuropeptide; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT PEPTIDE 18..44
FT /note="Diapause hormone"
FT /evidence="ECO:0000269|PubMed:28502715"
FT /id="PRO_0000442319"
FT PROPEP 48..91
FT /evidence="ECO:0000303|PubMed:28502715"
FT /id="PRO_0000442320"
FT PEPTIDE 94..100
FT /note="Alpha-subesophageal ganglion neuropeptide"
FT /evidence="ECO:0000269|PubMed:28502715"
FT /id="PRO_0000442321"
FT PEPTIDE 103..120
FT /note="Beta-subesophageal ganglion neuropeptide"
FT /evidence="ECO:0000269|PubMed:28502715"
FT /id="PRO_0000442322"
FT PEPTIDE 124..156
FT /note="Pheromone biosynthesis-activating neuropeptide"
FT /evidence="ECO:0000269|PubMed:28502715"
FT /id="PRO_0000442323"
FT PEPTIDE 159..166
FT /note="Gamma-subesophageal ganglion neuropeptide"
FT /evidence="ECO:0000269|PubMed:28502715"
FT /id="PRO_0000442324"
FT PROPEP 169..191
FT /evidence="ECO:0000303|PubMed:28502715"
FT /id="PRO_0000442325"
FT MOD_RES 44
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:28502715"
FT MOD_RES 100
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:28502715"
FT MOD_RES 120
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:28502715"
FT MOD_RES 156
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:28502715"
FT MOD_RES 166
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:28502715"
SQ SEQUENCE 191 AA; 21943 MW; 1EE8288515425A8F CRC64;
MFSPLLFFAV SISCVLANSN EIKDGGSDRG AHSDRAGLWF GPRLGKRSLR ISTEDNRQAF
FKLLEAADAL KYYYDRLPYE MQADEPETRV TKKVIFTPKL GRSLAYDDKV FENVEFTPRL
GRRLADDMPA TPADQELYRP DPDQIDSRTK YFSPRLGRTM NFSPRLGREL SYDMLPSKLR
LVRSTNRTQS T
