ID   PBAS_RAT                Reviewed;         177 AA.
AC   P15399; Q53Z30;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   03-AUG-2022, entry version 147.
DE   RecName: Full=Probasin;
DE            Short=PB;
DE   AltName: Full=M-40;
DE   Flags: Precursor;
GN   Name=Pbsn; Synonyms=Prbs;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND PROTEIN SEQUENCE OF
RP   18-40.
RX   PubMed=2682630; DOI=10.1073/pnas.86.20.7843;
RA   Spence A.M., Sheppard P.C., Davie J.R., Matuo Y., Nishi N., McKeehan W.L.,
RA   Dodd J.G., Matusik R.J.;
RT   "Regulation of a bifunctional mRNA results in synthesis of secreted and
RT   nuclear probasin.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:7843-7847(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RX   PubMed=11058766; DOI=10.1016/s0167-4838(00)00170-9;
RA   Kasper S., Matusik R.J.;
RT   "Rat probasin: structure and function of an outlier lipocalin.";
RL   Biochim. Biophys. Acta 1482:249-258(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus. Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=1; Synonyms=Secreted;
CC         IsoId=P15399-1; Sequence=Displayed;
CC       Name=2; Synonyms=Nuclear;
CC         IsoId=P15399-2; Sequence=VSP_018809;
CC   -!- TISSUE SPECIFICITY: Prostatic epithelial cells.
CC   -!- INDUCTION: Androgen-regulated, increases in concentration with zinc
CC       uptake.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   EMBL; M27156; AAA40805.1; -; mRNA.
DR   EMBL; AY370611; AAQ67415.1; -; Genomic_DNA.
DR   EMBL; BC062035; AAH62035.1; -; mRNA.
DR   PIR; A32602; A32602.
DR   RefSeq; NP_061998.1; NM_019125.1. [P15399-1]
DR   RefSeq; XP_008771461.1; XM_008773239.2. [P15399-1]
DR   AlphaFoldDB; P15399; -.
DR   SMR; P15399; -.
DR   BioGRID; 248446; 1.
DR   IntAct; P15399; 1.
DR   STRING; 10116.ENSRNOP00000042730; -.
DR   PaxDb; P15399; -.
DR   PRIDE; P15399; -.
DR   GeneID; 54193; -.
DR   KEGG; rno:54193; -.
DR   CTD; 54192; -.
DR   RGD; 708571; Pbsn.
DR   VEuPathDB; HostDB:ENSRNOG00000003713; -.
DR   eggNOG; ENOG502TDZD; Eukaryota.
DR   HOGENOM; CLU_094061_4_2_1; -.
DR   InParanoid; P15399; -.
DR   OMA; PNENIDD; -.
DR   OrthoDB; 1357921at2759; -.
DR   PhylomeDB; P15399; -.
DR   TreeFam; TF338197; -.
DR   PRO; PR:P15399; -.
DR   Proteomes; UP000002494; Chromosome X.
DR   Bgee; ENSRNOG00000003713; Expressed in liver.
DR   Genevisible; P15399; RN.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR022272; Lipocalin_CS.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   InterPro; IPR002448; OBP-like.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR01173; ODORANTBNDNG.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00213; LIPOCALIN; 1.
PE   1: Evidence at protein level;
KW   Alternative initiation; Direct protein sequencing; Disulfide bond; Nucleus;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000269|PubMed:2682630"
FT   CHAIN           18..177
FT                   /note="Probasin"
FT                   /id="PRO_0000017955"
FT   DISULFID        79..170
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         1..17
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:2682630"
FT                   /id="VSP_018809"
SQ   SEQUENCE   177 AA;  20780 MW;  1805977EA136669A CRC64;
     MRVILLLLTL DVLGVSSMMT DKNLKKKIEG NWRTVYLAAS SVEKINEGSP LRTYFRRIEC
     GKRCNRINLY FYIKKGAKCQ QFKIVGRRSQ DVYYAKYEGS TAFMLKTVNE KILLFDYFNR
     NRRNDVTRVA GVLAKGRQLT KDEMTEYMNF VEEMGIEDEN VQRVMDTDTC PNKIRIR