PBCG_MESAU
ID PBCG_MESAU Reviewed; 175 AA.
AC Q92778; P70109; Q9QYF7;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Pancreatic beta cell growth factor;
DE AltName: Full=Islet neogenesis-associated protein;
DE Flags: Precursor;
GN Name=INGAP;
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION, AND
RP SYNTHESIS OF 104-118.
RC STRAIN=Syrian; TISSUE=Pancreas;
RX PubMed=9151782; DOI=10.1172/jci119383;
RA Rafaeloff R., Pittenger G.L., Barlow S.W., Qin X.F., Yan B., Rosenberg L.,
RA Duguid W.P., Vinik A.I.;
RT "Cloning and sequencing of the pancreatic islet neogenesis associated
RT protein (INGAP) gene and its expression in islet neogenesis in hamsters.";
RL J. Clin. Invest. 99:2100-2109(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Syrian; TISSUE=Liver;
RX PubMed=12757938; DOI=10.1016/s0925-4439(03)00042-5;
RA Taylor-Fishwick D.A., Rittman S., Kendall H., Roy L., Shi W., Cao Y.,
RA Pittenger G.L., Vinik A.I.;
RT "Cloning genomic INGAP: a Reg-related family member with distinct
RT transcriptional regulation sites.";
RL Biochim. Biophys. Acta 1638:83-89(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE OF 38-175.
RX PubMed=10767532; DOI=10.1016/s0378-1119(00)00059-7;
RA Abe M., Nata K., Akiyama T., Shervani N.J., Kobayashi S.,
RA Tomioka-Kumagai T., Ito S., Takasawa S., Okamoto H.;
RT "Identification of a novel Reg family gene, Reg III delta, and mapping of
RT all three types of Reg family gene in a 75 kilobase mouse genomic region.";
RL Gene 246:111-122(2000).
CC -!- FUNCTION: Constituent of ilotropin, which is a partially purified
CC preparation of cellophane wrapping (CW) pancreata. Capable of
CC initiating duct cell proliferation, a prerequisite for islet
CC neogenesis. {ECO:0000269|PubMed:9151782}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed only in CW animals pancreas and to a
CC lesser extent in duodenum. In pancreas it is found in acinar cells, but
CC not in islets. {ECO:0000269|PubMed:9151782}.
CC -!- INDUCTION: Found 1 and 2 days after cellophane wrapping, absent by the
CC 6th day. This period coincides with islet neogenesis.
CC {ECO:0000269|PubMed:9151782}.
CC -!- CAUTION: It is uncertain whether Met-1, Met-2 or Met-5 is the
CC initiator. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB16754.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAB86497.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U41737; AAB86497.1; ALT_INIT; mRNA.
DR EMBL; U41738; AAB16754.1; ALT_INIT; mRNA.
DR EMBL; AY184211; AAO63559.1; -; Genomic_DNA.
DR EMBL; AB035211; BAA88566.1; -; Genomic_DNA.
DR RefSeq; NP_001268484.1; NM_001281555.1.
DR AlphaFoldDB; Q92778; -.
DR SMR; Q92778; -.
DR STRING; 10036.XP_005078338.1; -.
DR GeneID; 101829186; -.
DR eggNOG; KOG4297; Eukaryota.
DR OrthoDB; 1509611at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR016187; CTDL_fold.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Lectin; Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000250"
FT CHAIN 27..175
FT /note="Pancreatic beta cell growth factor"
FT /id="PRO_0000017453"
FT DOMAIN 38..175
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 40..51
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 68..171
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 146..163
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ SEQUENCE 175 AA; 19940 MW; 3854F36BA35D17CE CRC64;
MMLPMTLCRM SWMLLSCLMF LSWVEGEESQ KKLPSSRITC PQGSVAYGSY CYSLILIPQT
WSNAELSCQM HFSGHLAFLL STGEITFVSS LVKNSLTAYQ YIWIGLHDPS HGTLPNGSGW
KWSSSNVLTF YNWERNPSIA ADRGYCAVLS QKSGFQKWRD FNCENELPYI CKFKV
