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PBDC1_MOUSE
ID   PBDC1_MOUSE             Reviewed;         198 AA.
AC   Q9D0B6; B1AUP5; Q8C5Z2; Q9CVL0;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Protein PBDC1;
DE   AltName: Full=Polysaccharide biosynthesis domain-containing protein 1;
GN   Name=Pbdc1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J; TISSUE=Embryo, Pancreas, Pituitary, and Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, Colon, and Thymus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC   Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9D0B6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9D0B6-2; Sequence=VSP_021180;
CC   -!- SIMILARITY: Belongs to the PBDC1 family. {ECO:0000305}.
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DR   EMBL; AK007655; BAB25165.3; -; mRNA.
DR   EMBL; AK011610; BAB27731.1; -; mRNA.
DR   EMBL; AK030507; BAC26994.1; -; mRNA.
DR   EMBL; AK076889; BAC36520.1; -; mRNA.
DR   EMBL; AL671897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC035042; AAH35042.1; -; mRNA.
DR   EMBL; BC044719; AAH44719.1; -; mRNA.
DR   EMBL; BC061070; AAH61070.1; -; mRNA.
DR   CCDS; CCDS30334.1; -. [Q9D0B6-1]
DR   CCDS; CCDS72419.1; -. [Q9D0B6-2]
DR   RefSeq; NP_001268800.1; NM_001281871.1. [Q9D0B6-2]
DR   RefSeq; NP_080588.1; NM_026312.5. [Q9D0B6-1]
DR   AlphaFoldDB; Q9D0B6; -.
DR   SMR; Q9D0B6; -.
DR   BioGRID; 212364; 2.
DR   STRING; 10090.ENSMUSP00000033577; -.
DR   iPTMnet; Q9D0B6; -.
DR   PhosphoSitePlus; Q9D0B6; -.
DR   EPD; Q9D0B6; -.
DR   MaxQB; Q9D0B6; -.
DR   PaxDb; Q9D0B6; -.
DR   PeptideAtlas; Q9D0B6; -.
DR   PRIDE; Q9D0B6; -.
DR   ProteomicsDB; 287791; -. [Q9D0B6-1]
DR   ProteomicsDB; 287792; -. [Q9D0B6-2]
DR   Antibodypedia; 507; 199 antibodies from 19 providers.
DR   DNASU; 67683; -.
DR   Ensembl; ENSMUST00000033577; ENSMUSP00000033577; ENSMUSG00000031226. [Q9D0B6-1]
DR   Ensembl; ENSMUST00000119477; ENSMUSP00000113288; ENSMUSG00000031226. [Q9D0B6-2]
DR   GeneID; 67683; -.
DR   KEGG; mmu:67683; -.
DR   UCSC; uc009uat.2; mouse. [Q9D0B6-1]
DR   CTD; 51260; -.
DR   MGI; MGI:1914933; Pbdc1.
DR   VEuPathDB; HostDB:ENSMUSG00000031226; -.
DR   eggNOG; KOG4093; Eukaryota.
DR   GeneTree; ENSGT00390000016333; -.
DR   HOGENOM; CLU_103791_0_0_1; -.
DR   InParanoid; Q9D0B6; -.
DR   OMA; MELMHGA; -.
DR   OrthoDB; 1420225at2759; -.
DR   PhylomeDB; Q9D0B6; -.
DR   TreeFam; TF314442; -.
DR   BioGRID-ORCS; 67683; 3 hits in 70 CRISPR screens.
DR   ChiTaRS; Pbdc1; mouse.
DR   PRO; PR:Q9D0B6; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; Q9D0B6; protein.
DR   Bgee; ENSMUSG00000031226; Expressed in epiblast (generic) and 69 other tissues.
DR   Genevisible; Q9D0B6; MM.
DR   Gene3D; 1.10.3560.10; -; 1.
DR   InterPro; IPR023139; PBDC1-like_dom_sf.
DR   InterPro; IPR008476; PBDC1_metazoa/fungi.
DR   InterPro; IPR021148; Polysacc_synth_dom.
DR   PANTHER; PTHR13410; PTHR13410; 1.
DR   Pfam; PF04669; Polysacc_synt_4; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Phosphoprotein; Reference proteome.
FT   CHAIN           1..198
FT                   /note="Protein PBDC1"
FT                   /id="PRO_0000254106"
FT   REGION          163..198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..198
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         126
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BVG4"
FT   MOD_RES         184
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BVG4"
FT   VAR_SEQ         138..198
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_021180"
SQ   SEQUENCE   198 AA;  22223 MW;  625C4B264303825C CRC64;
     MDAAGESEEP VSGEALSIAH ALSHPPESYG NDPDIEMAWA IRAMQHAEVY YKLISSVDPQ
     FLKLTKVDDQ IYSEFREIFE TLRVDVLDPE ELKSESAKEK WRPFCLKFEG IVEDYNYGTL
     LRLDCSQGYT EENTIFAPRI QFFAIEIARN REGYNKAVSV SIQDKEGEEG AGNKEEAAEK
     GADSGGEKEE GANREGEK
 
 
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