PBIR1_CHICK
ID PBIR1_CHICK Reviewed; 284 AA.
AC Q5ZLN7;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=P2R1A-PPP2R2A-interacting phosphatase regulator 1 {ECO:0000250|UniProtKB:Q96E09};
DE AltName: Full=PABIR family member 1 {ECO:0000250|UniProtKB:Q96E09};
GN Name=PABIR1 {ECO:0000250|UniProtKB:Q96E09};
GN Synonyms=FAM122A {ECO:0000250|UniProtKB:Q96E09}; ORFNames=RCJMB04_5g5;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Acts as an inhibitor of serine/threonine-protein phosphatase
CC 2A (PP2A) activity. Potentiates ubiquitin-mediated proteasomal
CC degradation of serine/threonine-protein phosphatase 2A catalytic
CC subunit alpha (PPP2CA). Inhibits PP2A-mediated dephosphorylation of
CC WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby
CC releasing G2/M checkpoint. {ECO:0000250|UniProtKB:Q96E09}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96E09}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q96E09}.
CC -!- SIMILARITY: Belongs to the FAM122 family. {ECO:0000305}.
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DR EMBL; AJ719697; CAG31356.1; -; mRNA.
DR RefSeq; NP_001026289.1; NM_001031118.1.
DR AlphaFoldDB; Q5ZLN7; -.
DR STRING; 9031.ENSGALP00000009875; -.
DR Ensembl; ENSGALT00000009889; ENSGALP00000009875; ENSGALG00000006127.
DR GeneID; 422237; -.
DR KEGG; gga:422237; -.
DR CTD; 159091; -.
DR VEuPathDB; HostDB:geneid_422237; -.
DR eggNOG; ENOG502QTCH; Eukaryota.
DR GeneTree; ENSGT00390000015476; -.
DR HOGENOM; CLU_083344_0_0_1; -.
DR InParanoid; Q5ZLN7; -.
DR OMA; MNLMNRE; -.
DR OrthoDB; 1406067at2759; -.
DR PhylomeDB; Q5ZLN7; -.
DR PRO; PR:Q5ZLN7; -.
DR Proteomes; UP000000539; Chromosome 4.
DR Bgee; ENSGALG00000006127; Expressed in spleen and 14 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0004865; F:protein serine/threonine phosphatase inhibitor activity; ISS:UniProtKB.
DR GO; GO:0044818; P:mitotic G2/M transition checkpoint; ISS:UniProtKB.
DR GO; GO:0030307; P:positive regulation of cell growth; ISS:UniProtKB.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR InterPro; IPR026716; PBIR1/2/3.
DR PANTHER; PTHR22227; PTHR22227; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Protein phosphatase inhibitor; Reference proteome.
FT CHAIN 1..284
FT /note="P2R1A-PPP2R2A-interacting phosphatase regulator 1"
FT /id="PRO_0000089688"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 284 AA; 30523 MW; 7653E2BACAE8ABD1 CRC64;
MAQEKMELDL ELPPGSAAAP SDGGGLRRSN SAPLIHGLSD NSQVFQGSVL RTRRNSTTVM
NRHSLFVPSS PIRIPSSRLH QIKQEEGMNL MNRETVHERE VQVAMQMSQS WEESLSLSNN
DFEKSSSPKQ VDFVPVSPAP SPTRGIGKQC FSPSLQSLVS SSGLPPSPSP SPTRRFSSRR
SQSPINCIRP SVLGPIKRKG VTEMEDHPKR LFQGSTNMLS SEALHQPDLG GCLSAHTLDD
NRSSAGSSCD SPAEAGASTG SPVSLSDSRS PFLPVDLTAK LPID
