PBIR2_MOUSE
ID PBIR2_MOUSE Reviewed; 255 AA.
AC Q6NZE7; B1B0Y4; B1B0Y5; Q8BRG5; Q8CBB0; Q9D2N2;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=PABIR family member 2 {ECO:0000250|UniProtKB:Q7Z309};
GN Name=Pabir2 {ECO:0000250|UniProtKB:Q7Z309};
GN Synonyms=Fam122b {ECO:0000312|MGI:MGI:1926005};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
RC STRAIN=C57BL/6J; TISSUE=Bone, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58; SER-115 AND SER-119, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Liver, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q6NZE7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NZE7-2; Sequence=VSP_021219;
CC Name=3;
CC IsoId=Q6NZE7-3; Sequence=VSP_021220;
CC Name=4;
CC IsoId=Q6NZE7-4; Sequence=VSP_021221;
CC -!- SIMILARITY: Belongs to the FAM122 family. {ECO:0000305}.
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DR EMBL; AK019480; BAB31749.1; -; mRNA.
DR EMBL; AK036417; BAC29421.1; -; mRNA.
DR EMBL; AK044896; BAC32133.1; -; mRNA.
DR EMBL; BX679674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC066167; AAH66167.1; -; mRNA.
DR CCDS; CCDS30129.1; -. [Q6NZE7-2]
DR CCDS; CCDS53069.1; -. [Q6NZE7-3]
DR CCDS; CCDS53070.1; -. [Q6NZE7-1]
DR RefSeq; NP_001159837.2; NM_001166365.2. [Q6NZE7-1]
DR RefSeq; NP_001160055.1; NM_001166583.1. [Q6NZE7-3]
DR RefSeq; NP_084443.1; NM_030167.4. [Q6NZE7-2]
DR AlphaFoldDB; Q6NZE7; -.
DR STRING; 10090.ENSMUSP00000110487; -.
DR iPTMnet; Q6NZE7; -.
DR PhosphoSitePlus; Q6NZE7; -.
DR jPOST; Q6NZE7; -.
DR MaxQB; Q6NZE7; -.
DR PaxDb; Q6NZE7; -.
DR PRIDE; Q6NZE7; -.
DR ProteomicsDB; 271512; -. [Q6NZE7-1]
DR ProteomicsDB; 271513; -. [Q6NZE7-2]
DR ProteomicsDB; 271514; -. [Q6NZE7-3]
DR ProteomicsDB; 271515; -. [Q6NZE7-4]
DR Antibodypedia; 425; 65 antibodies from 16 providers.
DR DNASU; 78755; -.
DR Ensembl; ENSMUST00000071023; ENSMUSP00000069112; ENSMUSG00000036022. [Q6NZE7-2]
DR Ensembl; ENSMUST00000114838; ENSMUSP00000110487; ENSMUSG00000036022. [Q6NZE7-1]
DR Ensembl; ENSMUST00000114841; ENSMUSP00000110490; ENSMUSG00000036022. [Q6NZE7-3]
DR GeneID; 78755; -.
DR KEGG; mmu:78755; -.
DR UCSC; uc009tev.2; mouse. [Q6NZE7-2]
DR UCSC; uc009tew.2; mouse. [Q6NZE7-1]
DR UCSC; uc009tex.2; mouse. [Q6NZE7-4]
DR UCSC; uc009tey.2; mouse. [Q6NZE7-3]
DR CTD; 78755; -.
DR MGI; MGI:1926005; Fam122b.
DR VEuPathDB; HostDB:ENSMUSG00000036022; -.
DR eggNOG; ENOG502QTCH; Eukaryota.
DR GeneTree; ENSGT00390000015476; -.
DR HOGENOM; CLU_083344_0_0_1; -.
DR InParanoid; Q6NZE7; -.
DR OMA; RRFCNRR; -.
DR OrthoDB; 1406067at2759; -.
DR PhylomeDB; Q6NZE7; -.
DR TreeFam; TF330808; -.
DR BioGRID-ORCS; 78755; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Fam122b; mouse.
DR PRO; PR:Q6NZE7; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q6NZE7; protein.
DR Bgee; ENSMUSG00000036022; Expressed in superior cervical ganglion and 194 other tissues.
DR ExpressionAtlas; Q6NZE7; baseline and differential.
DR Genevisible; Q6NZE7; MM.
DR GO; GO:0004865; F:protein serine/threonine phosphatase inhibitor activity; IEA:InterPro.
DR InterPro; IPR026716; PBIR1/2/3.
DR PANTHER; PTHR22227; PTHR22227; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Methylation; Phosphoprotein;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q7Z309"
FT CHAIN 2..255
FT /note="PABIR family member 2"
FT /id="PRO_0000254546"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z309"
FT MOD_RES 25
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z309"
FT MOD_RES 33
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z309"
FT MOD_RES 50
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z309"
FT MOD_RES 58
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 112
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z309"
FT MOD_RES 115
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 119
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 122
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z309"
FT MOD_RES 145
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z309"
FT VAR_SEQ 154
FT /note="S -> SS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021219"
FT VAR_SEQ 208..255
FT /note="CSDILDGSSISSGLSSDSLATGSAPAESPVACSNSCSPFILMDDLSPK ->
FT WWCYQGEEIPALTRCVEHLQMNE (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021220"
FT VAR_SEQ 208..255
FT /note="CSDILDGSSISSGLSSDSLATGSAPAESPVACSNSCSPFILMDDLSPK ->
FT WWGSLHGGVSDFE (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021221"
FT CONFLICT 64
FT /note="D -> G (in Ref. 1; BAC32133)"
FT /evidence="ECO:0000305"
FT CONFLICT 94
FT /note="D -> G (in Ref. 3; AAH66167)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 255 AA; 27686 MW; 352B48C29097B226 CRC64;
MAQEKMDLDF EADTSEGATL RRSNSAPLIH VLSDLSQVFE PYPLRTGRTS TAIMSHHSLE
EGLDMMNRET TNEREAQAGM QISQSWDESL SLSDSDFDKP EKLYSPKRID FTPVSPAPSP
TRGFGKQCLS PSLQMFVSSS GMPPSPVLNP RHFSRRSQSP VKCIRPSVLG PLKRKGEMEM
ESQPKRPFQG TTSMLSTNPA QLSDFSSCSD ILDGSSISSG LSSDSLATGS APAESPVACS
NSCSPFILMD DLSPK
