PBIR3_HUMAN
ID PBIR3_HUMAN Reviewed; 195 AA.
AC Q6P4D5; F5H036; Q8WVK9;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=PABIR family member 1 {ECO:0000312|HGNC:HGNC:25202};
GN Name=PABIR3 {ECO:0000312|HGNC:HGNC:25202}; Synonyms=FAM122C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Cervix carcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Pancreas, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6P4D5-2; P28288-2: ABCD3; NbExp=3; IntAct=EBI-9091052, EBI-25889034;
CC Q6P4D5-2; P27797: CALR; NbExp=3; IntAct=EBI-9091052, EBI-1049597;
CC Q6P4D5-2; P02489: CRYAA; NbExp=3; IntAct=EBI-9091052, EBI-6875961;
CC Q6P4D5-2; P36957: DLST; NbExp=3; IntAct=EBI-9091052, EBI-351007;
CC Q6P4D5-2; P25685: DNAJB1; NbExp=3; IntAct=EBI-9091052, EBI-357034;
CC Q6P4D5-2; Q14204: DYNC1H1; NbExp=3; IntAct=EBI-9091052, EBI-356015;
CC Q6P4D5-2; P00488: F13A1; NbExp=3; IntAct=EBI-9091052, EBI-2565863;
CC Q6P4D5-2; O14908-2: GIPC1; NbExp=3; IntAct=EBI-9091052, EBI-25913156;
CC Q6P4D5-2; Q92876: KLK6; NbExp=3; IntAct=EBI-9091052, EBI-2432309;
CC Q6P4D5-2; Q8TDX7: NEK7; NbExp=3; IntAct=EBI-9091052, EBI-1055945;
CC Q6P4D5-2; P51812: RPS6KA3; NbExp=3; IntAct=EBI-9091052, EBI-1046616;
CC Q6P4D5-2; P53999: SUB1; NbExp=3; IntAct=EBI-9091052, EBI-998260;
CC Q6P4D5-2; Q15545: TAF7; NbExp=3; IntAct=EBI-9091052, EBI-1560194;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6P4D5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P4D5-2; Sequence=VSP_021222;
CC Name=3;
CC IsoId=Q6P4D5-3; Sequence=VSP_044990, VSP_044991, VSP_044992;
CC -!- SIMILARITY: Belongs to the FAM122 family. {ECO:0000305}.
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DR EMBL; AK307219; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; Z83826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL691477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC017868; AAH17868.1; -; mRNA.
DR EMBL; BC063491; AAH63491.1; -; mRNA.
DR CCDS; CCDS14644.1; -. [Q6P4D5-2]
DR CCDS; CCDS55500.1; -. [Q6P4D5-3]
DR CCDS; CCDS55501.1; -. [Q6P4D5-1]
DR RefSeq; NP_001164250.1; NM_001170779.1. [Q6P4D5-1]
DR RefSeq; NP_001164251.1; NM_001170780.1. [Q6P4D5-3]
DR RefSeq; NP_001164252.1; NM_001170781.1.
DR RefSeq; NP_001164254.1; NM_001170783.1.
DR RefSeq; NP_620174.1; NM_138819.3. [Q6P4D5-2]
DR AlphaFoldDB; Q6P4D5; -.
DR BioGRID; 127731; 9.
DR IntAct; Q6P4D5; 14.
DR STRING; 9606.ENSP00000359820; -.
DR iPTMnet; Q6P4D5; -.
DR PhosphoSitePlus; Q6P4D5; -.
DR BioMuta; FAM122C; -.
DR DMDM; 74737331; -.
DR jPOST; Q6P4D5; -.
DR MassIVE; Q6P4D5; -.
DR PaxDb; Q6P4D5; -.
DR PeptideAtlas; Q6P4D5; -.
DR PRIDE; Q6P4D5; -.
DR ProteomicsDB; 25215; -.
DR ProteomicsDB; 66960; -. [Q6P4D5-1]
DR ProteomicsDB; 66961; -. [Q6P4D5-2]
DR Antibodypedia; 66492; 20 antibodies from 9 providers.
DR DNASU; 159091; -.
DR Ensembl; ENST00000370784.8; ENSP00000359820.4; ENSG00000156500.16. [Q6P4D5-1]
DR Ensembl; ENST00000370785.4; ENSP00000359821.3; ENSG00000156500.16. [Q6P4D5-2]
DR Ensembl; ENST00000414371.6; ENSP00000402477.2; ENSG00000156500.16. [Q6P4D5-3]
DR GeneID; 159091; -.
DR KEGG; hsa:159091; -.
DR UCSC; uc004exy.3; human. [Q6P4D5-1]
DR CTD; 159091; -.
DR GeneCards; PABIR3; -.
DR HGNC; HGNC:25202; PABIR3.
DR HPA; ENSG00000156500; Tissue enhanced (ovary).
DR neXtProt; NX_Q6P4D5; -.
DR OpenTargets; ENSG00000156500; -.
DR VEuPathDB; HostDB:ENSG00000156500; -.
DR eggNOG; ENOG502QTCH; Eukaryota.
DR GeneTree; ENSGT00390000015476; -.
DR HOGENOM; CLU_169772_0_0_1; -.
DR InParanoid; Q6P4D5; -.
DR PhylomeDB; Q6P4D5; -.
DR TreeFam; TF330808; -.
DR PathwayCommons; Q6P4D5; -.
DR SignaLink; Q6P4D5; -.
DR BioGRID-ORCS; 159091; 10 hits in 704 CRISPR screens.
DR ChiTaRS; FAM122C; human.
DR GenomeRNAi; 159091; -.
DR Pharos; Q6P4D5; Tdark.
DR PRO; PR:Q6P4D5; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q6P4D5; protein.
DR Bgee; ENSG00000156500; Expressed in left ovary and 111 other tissues.
DR ExpressionAtlas; Q6P4D5; baseline and differential.
DR Genevisible; Q6P4D5; HS.
DR GO; GO:0004865; F:protein serine/threonine phosphatase inhibitor activity; IEA:InterPro.
DR InterPro; IPR026716; PBIR1/2/3.
DR PANTHER; PTHR22227; PTHR22227; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..195
FT /note="PABIR family member 1"
FT /id="PRO_0000254547"
FT VAR_SEQ 1
FT /note="M -> MAYFPGTGRTDQETQLDLSLCGREPESLENLFLDPDM (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044990"
FT VAR_SEQ 64..79
FT /note="LLPPPPFHGSISRLHQ -> EITSPTSVEQKPKDLF (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044991"
FT VAR_SEQ 80..195
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044992"
FT VAR_SEQ 116..195
FT /note="VKWHFNINQKRFSKAQPTCFLLILPNCQKIMCIYFQLLLMETTAMLDLLVIR
FT QLKSALSQTLLCHLLILVLICSSRQTFN -> NDNGLQKSSSLKCIDLTPVSSMASSIK
FT KTGKSTSSYF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021222"
SQ SEQUENCE 195 AA; 22522 MW; 34D52D1B1601153E CRC64;
MAQEKMKLGF KSLPSSTTAD GNILRRVNSA PLINGLGFNS QVLQADMLRI RTNRTTFRNR
RSLLLPPPPF HGSISRLHQI KQEEAMDLIN RETMSEWKLQ SEIQISHSWE EGLKLVKWHF
NINQKRFSKA QPTCFLLILP NCQKIMCIYF QLLLMETTAM LDLLVIRQLK SALSQTLLCH
LLILVLICSS RQTFN
