ID   PBL9F_EUGGR             Reviewed;         855 AA.
AC   P84740; Q2P9M7;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Photoactivated adenylate cyclase subunit beta-like protein 1224-5/9F;
GN   Name=pacB {ECO:0000312|EMBL:CAJ57397.1};
OS   Euglena gracilis.
OC   Eukaryota; Discoba; Euglenozoa; Euglenida; Spirocuta; Euglenophyceae;
OC   Euglenales; Euglenaceae; Euglena.
OX   NCBI_TaxID=3039;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAJ57397.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RC   STRAIN=SAG 1224-5/9F;
RX   PubMed=16121285; DOI=10.1039/b502002f;
RA   Ntefidou M., Haeder D.-P.;
RT   "Photoactivated adenylyl cyclase (PAC) genes in the flagellate Euglena
RT   gracilis mutant strains.";
RL   Photochem. Photobiol. Sci. 4:732-739(2005).
CC   -!- SUBUNIT: Heterotetramer of two alpha and two beta subunits.
CC       {ECO:0000250|UniProtKB:Q8S9F1}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000269|PubMed:16121285}. Note=Paraxonemal body. And paraxonemal
CC       bodies (PABs).
CC   -!- MISCELLANEOUS: The 1224-5/9F strain is deficient in phototaxis. It is
CC       not known if this is due to defective adenylate cyclase activity or
CC       defective BLUF domains in this protein. {ECO:0000269|PubMed:16121285}.
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DR   EMBL; AM181338; CAJ57397.1; -; mRNA.
DR   AlphaFoldDB; P84740; -.
DR   SMR; P84740; -.
DR   GO; GO:0031514; C:motile cilium; IDA:UniProtKB.
DR   GO; GO:0009882; F:blue light photoreceptor activity; IEA:InterPro.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; -; 2.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR036046; Acylphosphatase-like_dom_sf.
DR   InterPro; IPR007024; BLUF_domain.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   Pfam; PF04940; BLUF; 2.
DR   SMART; SM01034; BLUF; 2.
DR   SUPFAM; SSF54975; SSF54975; 2.
DR   SUPFAM; SSF55073; SSF55073; 2.
DR   PROSITE; PS50925; BLUF; 2.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Flagellum; Repeat.
FT   CHAIN           1..855
FT                   /note="Photoactivated adenylate cyclase subunit beta-like
FT                   protein 1224-5/9F"
FT                   /id="PRO_0000195723"
FT   DOMAIN          56..149
FT                   /note="BLUF 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00030"
FT   DOMAIN          471..563
FT                   /note="BLUF 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00030"
FT   REGION          420..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          813..855
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        814..842
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   855 AA;  93557 MW;  AAD4FBB7BC08D9F2 CRC64;
     MYILVWKKGQ QIKTFHTLDE AAQFKAASNF DEAPMFSVTV APAISASGGS NEATNLRRLM
     YLSKGTNPEE CNPQFVAELA RVATIRNREI GLSGFLMSSS PFLFQAIEGT DQDLDFLFAK
     ISADPRHERC IVLANRPCTG RMSGVWHMKD SHMDSITTHD AMMTILYQIA RSFSSMLTYL
     PKRAGNMLLS GLDPAAQPPE PKSVVVTFIY LVAYGSLLSN PYSTEQPAEV LSTFVDVCVK
     NLEGSGGIIT KFITGICMAS WPFNRTEEAL TAIQQISEDL AQLPSQQAPG SSPSLMYSQA
     GVHYGRAMLC NAGSGKSDFT LLGDWINTTS RIATLAKKLT SPVLFSFQVR CLLGDEMREE
     IEGAVMDQVK GRDKPVVEYQ FPGPERDVEV VGQKIEQFTP GRFRCQMRVG QYEALPISQR
     PPIFDDTPKC NPRPRTPGCE GRQRSHTLVD PHIMMAKLPG PSVSATGDTT VPTLTYISHA
     TRPMSRLDLS AIMGTATRIN ALQRITGTLL HGNGLFVQTQ EGPKEAEINL LLRIRQDTRR
     SDVATDHMPQ PQERVYPSEW TLTSGKEEIL AIFPPLQDVL SRLAKSFTAQ ETYVPSRVVS
     YLTAGNNPRE LMPVSCGVVM TDICSLTSLT ENSCLSEVWM ICNTFIDACP SAICQEGAEV
     IKLIGNCVTA YFPGNNADSA VASAQELFTF CREHRQAIVD VLDVRGCVSY GVALDNGQVV
     MAQCGSEGLT EYVVAGAVSA RVMEVEAITR GTCPRWATPL WSADRLSPQL RDHGIVPTPQ
     AIEGLPCYGI AGEEFELDVD SIKLGIKALH AARSGEKPLT EPEEAKLDFS PGRVRHGDSG
     RRSNSAQGKL SIQVR