ID   PBLD1_MOUSE             Reviewed;         288 AA.
AC   Q9DCG6; Q8VCF3;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 2.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Phenazine biosynthesis-like domain-containing protein 1;
DE            EC=5.1.-.-;
GN   Name=Pbld1; Synonyms=Mawbp2, Pbld;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Kidney;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Kidney, Liver, and Pancreas;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SIMILARITY: Belongs to the PhzF family. {ECO:0000305}.
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DR   EMBL; AK002802; BAB22369.1; -; mRNA.
DR   EMBL; AK143947; BAE25623.1; -; mRNA.
DR   EMBL; BC019997; AAH19997.1; -; mRNA.
DR   CCDS; CCDS23895.1; -.
DR   RefSeq; NP_080977.2; NM_026701.2.
DR   RefSeq; XP_006514095.1; XM_006514032.3.
DR   AlphaFoldDB; Q9DCG6; -.
DR   SMR; Q9DCG6; -.
DR   BioGRID; 212825; 2.
DR   iPTMnet; Q9DCG6; -.
DR   PhosphoSitePlus; Q9DCG6; -.
DR   jPOST; Q9DCG6; -.
DR   MaxQB; Q9DCG6; -.
DR   PaxDb; Q9DCG6; -.
DR   PRIDE; Q9DCG6; -.
DR   ProteomicsDB; 287963; -.
DR   DNASU; 68371; -.
DR   Ensembl; ENSMUST00000178684; ENSMUSP00000136589; ENSMUSG00000112129.
DR   GeneID; 68371; -.
DR   KEGG; mmu:68371; -.
DR   UCSC; uc007fju.1; mouse.
DR   CTD; 68371; -.
DR   MGI; MGI:1915621; Pbld1.
DR   VEuPathDB; HostDB:ENSMUSG00000112129; -.
DR   GeneTree; ENSGT00390000017595; -.
DR   HOGENOM; CLU_048756_2_0_1; -.
DR   InParanoid; Q9DCG6; -.
DR   OrthoDB; 1361558at2759; -.
DR   PhylomeDB; Q9DCG6; -.
DR   BioGRID-ORCS; 68371; 1 hit in 38 CRISPR screens.
DR   ChiTaRS; Pbld1; mouse.
DR   PRO; PR:Q9DCG6; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; Q9DCG6; protein.
DR   Bgee; ENSMUSG00000112129; Expressed in right kidney and 59 other tissues.
DR   ExpressionAtlas; Q9DCG6; baseline and differential.
DR   Genevisible; Q9DCG6; MM.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   GO; GO:0016853; F:isomerase activity; IBA:GO_Central.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0030277; P:maintenance of gastrointestinal epithelium; ISO:MGI.
DR   GO; GO:0060392; P:negative regulation of SMAD protein signal transduction; ISO:MGI.
DR   GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; ISO:MGI.
DR   InterPro; IPR003719; Phenazine_PhzF.
DR   PANTHER; PTHR13774; PTHR13774; 1.
DR   Pfam; PF02567; PhzC-PhzF; 1.
DR   PIRSF; PIRSF016184; PhzC_PhzF; 1.
DR   TIGRFAMs; TIGR00654; PhzF_family; 1.
PE   1: Evidence at protein level;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..288
FT                   /note="Phenazine biosynthesis-like domain-containing
FT                   protein 1"
FT                   /id="PRO_0000162385"
FT   ACT_SITE        46
FT                   /evidence="ECO:0000250"
FT   CONFLICT        209
FT                   /note="A -> P (in Ref. 1; BAB22369)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   288 AA;  32048 MW;  57C0230A82012D25 CRC64;
     MKLPIFIADA FTATAFRGNP AAVCLLERTL EEDAHQQIAR EMNLSETAFI RKLQPTDSFT
     QSSRFGLRWF TPVSEVPLCG HATLASAAVL FHKIQNRNST LTFVTMSGEL KARRAEDGIV
     LDFPVYPTFP QDFHEVEDLI KAAIGDTLVQ DIRYSTDTRK LLVRLSDSYD RSFLESLKVN
     TEPLPAIEKT GKVRGLILTV KGEPGGQTAP YDFYSRYFAP WVGIAEDPVT GSAHTVLSSY
     WSQQLRKKEM RAFQCSRRGG ELDISLRPDG RVDIKGGAVI VLEGTLTA