ID   PBLD2_MOUSE             Reviewed;         288 AA.
AC   Q9CXN7; Q9D2W4;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Phenazine biosynthesis-like domain-containing protein 2;
DE            EC=5.1.-.-;
GN   Name=Pbld2; Synonyms=Mawbp1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Cecum, and Embryonic head;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney, Liver, and Pancreas;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SIMILARITY: Belongs to the PhzF family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK014198; BAB29200.1; -; mRNA.
DR   EMBL; AK018692; BAB31348.1; -; mRNA.
DR   EMBL; BC061073; AAH61073.1; -; mRNA.
DR   CCDS; CCDS23894.1; -.
DR   RefSeq; NP_080361.1; NM_026085.2.
DR   AlphaFoldDB; Q9CXN7; -.
DR   SMR; Q9CXN7; -.
DR   BioGRID; 212092; 1.
DR   STRING; 10090.ENSMUSP00000020262; -.
DR   iPTMnet; Q9CXN7; -.
DR   PhosphoSitePlus; Q9CXN7; -.
DR   SwissPalm; Q9CXN7; -.
DR   jPOST; Q9CXN7; -.
DR   MaxQB; Q9CXN7; -.
DR   PaxDb; Q9CXN7; -.
DR   PeptideAtlas; Q9CXN7; -.
DR   PRIDE; Q9CXN7; -.
DR   ProteomicsDB; 294336; -.
DR   DNASU; 67307; -.
DR   Ensembl; ENSMUST00000020262; ENSMUSP00000020262; ENSMUSG00000020072.
DR   GeneID; 67307; -.
DR   KEGG; mmu:67307; -.
DR   UCSC; uc007fjr.1; mouse.
DR   CTD; 67307; -.
DR   MGI; MGI:1914557; Pbld2.
DR   VEuPathDB; HostDB:ENSMUSG00000020072; -.
DR   eggNOG; KOG3033; Eukaryota.
DR   GeneTree; ENSGT00390000017595; -.
DR   HOGENOM; CLU_048756_2_0_1; -.
DR   InParanoid; Q9CXN7; -.
DR   OMA; TEIDFCG; -.
DR   OrthoDB; 1361558at2759; -.
DR   PhylomeDB; Q9CXN7; -.
DR   TreeFam; TF314596; -.
DR   BioGRID-ORCS; 67307; 1 hit in 58 CRISPR screens.
DR   ChiTaRS; Pbld2; mouse.
DR   PRO; PR:Q9CXN7; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; Q9CXN7; protein.
DR   Bgee; ENSMUSG00000020072; Expressed in left lobe of liver and 155 other tissues.
DR   ExpressionAtlas; Q9CXN7; baseline and differential.
DR   Genevisible; Q9CXN7; MM.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   GO; GO:0016853; F:isomerase activity; IBA:GO_Central.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0030277; P:maintenance of gastrointestinal epithelium; ISO:MGI.
DR   GO; GO:0060392; P:negative regulation of SMAD protein signal transduction; ISO:MGI.
DR   GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; ISO:MGI.
DR   InterPro; IPR003719; Phenazine_PhzF.
DR   PANTHER; PTHR13774; PTHR13774; 1.
DR   Pfam; PF02567; PhzC-PhzF; 1.
DR   PIRSF; PIRSF016184; PhzC_PhzF; 1.
DR   TIGRFAMs; TIGR00654; PhzF_family; 1.
PE   1: Evidence at protein level;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..288
FT                   /note="Phenazine biosynthesis-like domain-containing
FT                   protein 2"
FT                   /id="PRO_0000162384"
FT   ACT_SITE        46
FT                   /evidence="ECO:0000250"
FT   CONFLICT        15
FT                   /note="A -> L (in Ref. 1; BAB31348)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   288 AA;  31983 MW;  23E36F84CDA66F03 CRC64;
     MKLPIFIADA FTATAFRGNP AAVCLLERTL DEDAHQDIAR EMNLSETAFV RKLQPTDDFT
     QSSRFGLRWF TPEAEFPLCG HATLASAAVL FQKRKNTNST LTFVTMSGEL KARREEDGIV
     LDFPVYPTFP QDFHEVEDLI KAAIGDTLVQ DIRYSPDTKN LLVRLSDSYD RSFLESLKVN
     TEPLPAIEKT GKVRGLILTV KGEPGGQTAL YDFYSRCFAP WVGVAEDPVT GSTHTLLGPY
     WSEELGKKEM RAFQCSRRGG ELDINLRPDG RVDIKGGAVI VLEGTLTA