PBMU2_HUMAN
ID PBMU2_HUMAN Reviewed; 251 AA.
AC E2RYF7;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 1.
DT 25-MAY-2022, entry version 45.
DE RecName: Full=Protein PBMUCL2;
DE AltName: Full=HLA complex group 22;
DE AltName: Full=Panbronchiolitis-related mucin-like protein 2;
DE Flags: Precursor;
GN Name=HCG22; Synonyms=G2, PBMUCL2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Lung;
RX PubMed=20981447; DOI=10.1007/s00439-010-0906-4;
RA Hijikata M., Matsushita I., Tanaka G., Tsuchiya T., Itoh H., Tokunaga K.,
RA Ohashi J., Homma S., Kobashi Y., Taguchi Y., Azuma A., Kudoh S., Keicho N.;
RT "Molecular cloning of two novel mucin-like genes in the disease-
RT susceptibility locus for diffuse panbronchiolitis.";
RL Hum. Genet. 129:117-128(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Detected in the brain, lung, spleen, thymus and
CC prostate. {ECO:0000269|PubMed:20981447}.
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DR EMBL; AB560771; BAJ24155.1; -; mRNA.
DR EMBL; CR759772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001335178.1; NM_001348249.1.
DR AlphaFoldDB; E2RYF7; -.
DR GlyGen; E2RYF7; 1 site.
DR BioMuta; HGNC:27780; -.
DR PeptideAtlas; E2RYF7; -.
DR PRIDE; E2RYF7; -.
DR ProteomicsDB; 15280; -.
DR DNASU; 285834; -.
DR GeneID; 285834; -.
DR KEGG; hsa:285834; -.
DR CTD; 285834; -.
DR DisGeNET; 285834; -.
DR GeneCards; HCG22; -.
DR HGNC; HGNC:27780; HCG22.
DR MIM; 613918; gene.
DR neXtProt; NX_E2RYF7; -.
DR InParanoid; E2RYF7; -.
DR OrthoDB; 1369254at2759; -.
DR PathwayCommons; E2RYF7; -.
DR GenomeRNAi; 285834; -.
DR Pharos; E2RYF7; Tdark.
DR PRO; PR:E2RYF7; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; E2RYF7; protein.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR037648; PBMUCL2.
DR PANTHER; PTHR22467:SF1; PTHR22467:SF1; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..251
FT /note="Protein PBMUCL2"
FT /id="PRO_0000410471"
FT REGION 36..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..251
FT /note="15 X 11 AA approximate repeats"
FT COMPBIAS 75..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 120
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 251 AA; 26282 MW; CC3DEAC2A4617A1F CRC64;
MPRYVPLLLL LLLLRCSERG GGVNFGEKDA KVPGTWRDGV RVPGEGASWD SDRASPERRY
GIVGLSQSIS TKHPETSPKD SRIRENDVTA DGRTTEDHIT ADPGTTEDSV TADPGTTEDN
VTVDPGTTEG SVTADPATTK DYVSADPGTT KDSVTADPGT TENFVTADPG TTKDSITADP
RTTEDSVTAD PGTTKHSITV DPGTTEDSVT ADPGTTKHSI TADPGTTEDS VTADPGTTED
ETTKHGDTHL L
