PBOV1_HUMAN
ID PBOV1_HUMAN Reviewed; 135 AA.
AC Q9GZY1;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Prostate and breast cancer overexpressed gene 1 protein;
DE AltName: Full=Protein UROC28;
DE Short=UC28;
GN Name=PBOV1; Synonyms=UROC28;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Prostatic carcinoma;
RX PubMed=11156405;
RA An G., Ng A.Y., Meka C.S.R., Luo G., Bright S.P., Cazares L.,
RA Wright G.L. Jr., Veltri R.W.;
RT "Cloning and characterization of UROC28, a novel gene overexpressed in
RT prostate, breast, and bladder cancers.";
RL Cancer Res. 60:7014-7020(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11156405}. Nucleus
CC {ECO:0000269|PubMed:11156405}.
CC -!- TISSUE SPECIFICITY: Expressed in colon, prostate, small intestine,
CC testis and spleen, with lower expression in thymus, ovary, and
CC peripheral blood leukocytes. Up-regulated expression in prostate,
CC breast, and bladder cancer, but not in lung and colon cancer.
CC {ECO:0000269|PubMed:11156405}.
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DR EMBL; AF189269; AAG17117.1; -; mRNA.
DR EMBL; AF189270; AAG17118.1; -; mRNA.
DR EMBL; AL031433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069109; AAH69109.1; -; mRNA.
DR CCDS; CCDS5190.1; -.
DR RefSeq; NP_067648.1; NM_021635.2.
DR AlphaFoldDB; Q9GZY1; -.
DR BioMuta; PBOV1; -.
DR PaxDb; Q9GZY1; -.
DR PeptideAtlas; Q9GZY1; -.
DR PRIDE; Q9GZY1; -.
DR Antibodypedia; 59014; 115 antibodies from 19 providers.
DR DNASU; 59351; -.
DR Ensembl; ENST00000527246.3; ENSP00000432353.1; ENSG00000254440.3.
DR GeneID; 59351; -.
DR KEGG; hsa:59351; -.
DR MANE-Select; ENST00000527246.3; ENSP00000432353.1; NM_021635.3; NP_067648.1.
DR UCSC; uc003qhv.5; human.
DR CTD; 59351; -.
DR DisGeNET; 59351; -.
DR GeneCards; PBOV1; -.
DR HGNC; HGNC:21079; PBOV1.
DR HPA; ENSG00000254440; Tissue enriched (brain).
DR MIM; 605669; gene.
DR neXtProt; NX_Q9GZY1; -.
DR OpenTargets; ENSG00000254440; -.
DR PharmGKB; PA134869958; -.
DR VEuPathDB; HostDB:ENSG00000254440; -.
DR eggNOG; ENOG502TFC8; Eukaryota.
DR GeneTree; ENSGT00390000009242; -.
DR HOGENOM; CLU_1885075_0_0_1; -.
DR OMA; SHHAILT; -.
DR OrthoDB; 1526487at2759; -.
DR PathwayCommons; Q9GZY1; -.
DR SignaLink; Q9GZY1; -.
DR BioGRID-ORCS; 59351; 5 hits in 988 CRISPR screens.
DR ChiTaRS; PBOV1; human.
DR GenomeRNAi; 59351; -.
DR Pharos; Q9GZY1; Tbio.
DR PRO; PR:Q9GZY1; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9GZY1; protein.
DR Bgee; ENSG00000254440; Expressed in colonic epithelium and 10 other tissues.
DR Genevisible; Q9GZY1; HS.
DR GO; GO:0034451; C:centriolar satellite; IDA:HPA.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..135
FT /note="Prostate and breast cancer overexpressed gene 1
FT protein"
FT /id="PRO_0000076285"
FT VARIANT 73
FT /note="I -> T (in dbSNP:rs6927706)"
FT /id="VAR_059707"
SQ SEQUENCE 135 AA; 15722 MW; 2B7DB8B1983705D0 CRC64;
MRAFLRNQKY EDMHNIIHIL QIRKLRHRLS NFPRLPGILA PETVLLPFCY KVFRKKEKVK
RSQKATEFID YSIEQSHHAI LTPLQTHLTM KGSSMKCSSL SSEAILFTLT LQLTQTLGLE
CCLLYLSKTI HPQII
