PBP6_DROME
ID PBP6_DROME Reviewed; 141 AA.
AC Q23970; P91684; Q9VNK3;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Pheromone-binding protein-related protein 6;
DE Short=PBPRP-6;
DE AltName: Full=Odorant-binding protein OS-E;
DE Flags: Precursor;
GN Name=Obp83b; Synonyms=Os-E, PBPRP6; ORFNames=CG11422;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=CS-5; TISSUE=Antenna;
RX PubMed=8206941; DOI=10.1016/s0021-9258(17)34013-9;
RA McKenna M.P., Hekmat-Scafe D.S., Gaines P., Carlson J.R.;
RT "Putative Drosophila pheromone-binding proteins expressed in a subregion of
RT the olfactory system.";
RL J. Biol. Chem. 269:16340-16347(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=Canton-S;
RX PubMed=9030621; DOI=10.1523/jneurosci.17-05-01616.1997;
RA Hekmat-Scafe D.S., Steinbrecht R.A., Carlson J.R.;
RT "Coexpression of two odorant-binding protein homologs in Drosophila:
RT implications for olfactory coding.";
RL J. Neurosci. 17:1616-1624(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=M11, M13, M2, M20, M22, M23, M26, M36, M40, M47, M54, M55, M59, and
RC M66;
RX PubMed=14668382; DOI=10.1093/genetics/165.3.1279;
RA Sanchez-Gracia A., Aguade M., Rozas J.;
RT "Patterns of nucleotide polymorphism and divergence in the odorant-binding
RT protein genes OS-E and OS-F: analysis in the melanogaster species subgroup
RT of Drosophila.";
RL Genetics 165:1279-1288(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Note=Secreted in the
CC lumen of olfactory hairs. {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Antenna. Mostly expressed in two types of sensory
CC hairs, sensilla trichodea and small sensilla basiconica, in the ventro-
CC lateral region of the third antennal segment (at protein level).
CC {ECO:0000269|PubMed:8206941, ECO:0000269|PubMed:9030621}.
CC -!- DEVELOPMENTAL STAGE: Expressed in adult but not in larval olfactory
CC organs. {ECO:0000269|PubMed:8206941}.
CC -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000305}.
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DR EMBL; U02543; AAA21356.1; -; mRNA.
DR EMBL; U81502; AAB51683.1; -; Genomic_DNA.
DR EMBL; AJ574644; CAE00882.1; -; Genomic_DNA.
DR EMBL; AJ574762; CAE00417.1; -; Genomic_DNA.
DR EMBL; AJ574763; CAE00419.1; -; Genomic_DNA.
DR EMBL; AJ574764; CAE00421.1; -; Genomic_DNA.
DR EMBL; AJ574765; CAE00423.1; -; Genomic_DNA.
DR EMBL; AJ574766; CAE00425.1; -; Genomic_DNA.
DR EMBL; AJ574767; CAE00427.1; -; Genomic_DNA.
DR EMBL; AJ574768; CAE00429.1; -; Genomic_DNA.
DR EMBL; AJ574769; CAE00431.1; -; Genomic_DNA.
DR EMBL; AJ574770; CAE00433.1; -; Genomic_DNA.
DR EMBL; AJ574771; CAE00435.1; -; Genomic_DNA.
DR EMBL; AJ574772; CAE00437.1; -; Genomic_DNA.
DR EMBL; AJ574773; CAE00439.1; -; Genomic_DNA.
DR EMBL; AJ574774; CAE00441.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF51928.1; -; Genomic_DNA.
DR RefSeq; NP_524242.2; NM_079518.3.
DR AlphaFoldDB; Q23970; -.
DR SMR; Q23970; -.
DR STRING; 7227.FBpp0078304; -.
DR PaxDb; Q23970; -.
DR DNASU; 40738; -.
DR EnsemblMetazoa; FBtr0078655; FBpp0078304; FBgn0010403.
DR GeneID; 40738; -.
DR KEGG; dme:Dmel_CG11422; -.
DR CTD; 40738; -.
DR FlyBase; FBgn0010403; Obp83b.
DR VEuPathDB; VectorBase:FBgn0010403; -.
DR eggNOG; ENOG502S7DV; Eukaryota.
DR GeneTree; ENSGT00520000056125; -.
DR HOGENOM; CLU_107288_1_0_1; -.
DR InParanoid; Q23970; -.
DR OMA; QEIHEDD; -.
DR OrthoDB; 1145531at2759; -.
DR PhylomeDB; Q23970; -.
DR BioGRID-ORCS; 40738; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 40738; -.
DR PRO; PR:Q23970; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0010403; Expressed in head capsule and 18 other tissues.
DR ExpressionAtlas; Q23970; baseline and differential.
DR Genevisible; Q23970; DM.
DR GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; ISS:FlyBase.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR Gene3D; 1.10.238.20; -; 1.
DR InterPro; IPR006170; PBP/GOBP.
DR InterPro; IPR036728; PBP_GOBP_sf.
DR Pfam; PF01395; PBP_GOBP; 1.
DR SMART; SM00708; PhBP; 1.
DR SUPFAM; SSF47565; SSF47565; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..141
FT /note="Pheromone-binding protein-related protein 6"
FT /id="PRO_0000012591"
FT DISULFID 41..72
FT /evidence="ECO:0000250"
FT DISULFID 68..120
FT /evidence="ECO:0000250"
FT DISULFID 111..129
FT /evidence="ECO:0000250"
FT CONFLICT 2
FT /note="V -> L (in Ref. 1; AAA21356)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 141 AA; 16112 MW; AD7E6D3E9DEF0538 CRC64;
MVKYPLILLL IGCAAAQEPR RDGEWPPPAI LKLGKHFHDI CAPKTGVTDE AIKEFSDGQI
HEDEALKCYM NCLFHEFEVV DDNGDVHMEK VLNAIPGEKL RNIMMEASKG CIHPEGDTLC
HKAWWFHQCW KKADPVHYFL V
