ID   A38_VACCC               Reviewed;         277 AA.
AC   P21061;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Protein A38;
GN   ORFNames=A38L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Promotes, when overexpressed, the influx of extracellular
CC       Ca2+, leading to membrane permeability and host cell necrosis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A38 protein family.
CC       {ECO:0000305}.
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DR   EMBL; M35027; AAA48168.1; -; Genomic_DNA.
DR   PIR; D42521; D42521.
DR   SMR; P21061; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0070053; F:thrombospondin receptor activity; IEA:InterPro.
DR   GO; GO:0022409; P:positive regulation of cell-cell adhesion; IEA:InterPro.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR006704; CD47.
DR   InterPro; IPR013147; CD47-like_TM.
DR   InterPro; IPR013270; CD47_Vset.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR10613; PTHR10613; 1.
DR   Pfam; PF04549; CD47; 1.
DR   Pfam; PF08204; V-set_CD47; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Host membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..277
FT                   /note="Protein A38"
FT                   /id="PRO_0000099324"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        29
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        58
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   277 AA;  31563 MW;  1B0903BE1D351E3C CRC64;
     MSRVRISLIY LYTLVVITTT KTIEYTACND TIIIPCTIDN PTKYIRWKLD NHDILTYNKT
     SKTTILSKWH TSARLHSLSD SDVSLIIEYK DILPGTYTCE DNTGIKSTVK LVQLHTNWFN
     DYQTMLMFIF TGITLFLLFL EITYTSISVV FSTNLGILQV FGCVIAMIEL CGAFLFYPSM
     FTLRHIIGLL MMTLPSIFLI ITKVFSFWLL CKLSCAVHLI IYYQLAGYIL TVLGLGLSLK
     ECVDGTLLLS GLGTIMVSEH FSLLFLVCFP STQRDYY