ID   PBP_MANSE               Reviewed;         168 AA.
AC   P18959;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Pheromone-binding protein;
DE            Short=PBP;
DE   Flags: Precursor;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 27-56.
RX   PubMed=3200861; DOI=10.1073/pnas.85.24.9851;
RA   Gyoergyi T.K., Roby-Shemkovitz A.J., Lerner M.R.;
RT   "Characterization and cDNA cloning of the pheromone-binding protein from
RT   the tobacco hornworm, Manduca sexta: a tissue-specific developmentally
RT   regulated protein.";
RL   Proc. Natl. Acad. Sci. U.S.A. 85:9851-9855(1988).
RN   [2]
RP   PROTEIN SEQUENCE OF 27-61.
RX   PubMed=2010751; DOI=10.1002/neu.480220108;
RA   Vogt R.G., Prestwich G.D., Lerner M.R.;
RT   "Odorant-binding-protein subfamilies associate with distinct classes of
RT   olfactory receptor neurons in insects.";
RL   J. Neurobiol. 22:74-84(1991).
CC   -!- FUNCTION: This major soluble protein in olfactory sensilla of male
CC       moths might serve to solubilize the extremely hydrophobic pheromone
CC       molecules and to transport pheromone through the aqueous lymph to
CC       receptors located on olfactory cilia. PBP is also found in sensilla
CC       from female M.sexta antennae.
CC   -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Antenna.
CC   -!- DEVELOPMENTAL STAGE: Its synthesis occurs around the time of eclosion.
CC   -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000305}.
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DR   EMBL; M21797; AAA29325.1; -; mRNA.
DR   EMBL; M21798; AAA29326.1; -; mRNA.
DR   PIR; A31770; A31770.
DR   AlphaFoldDB; P18959; -.
DR   SMR; P18959; -.
DR   GO; GO:0005550; F:pheromone binding; IEA:UniProtKB-KW.
DR   GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.238.20; -; 1.
DR   InterPro; IPR006072; Odorant/phero-bd_Lep.
DR   InterPro; IPR006170; PBP/GOBP.
DR   InterPro; IPR036728; PBP_GOBP_sf.
DR   Pfam; PF01395; PBP_GOBP; 1.
DR   PIRSF; PIRSF015604; Odorant/phero_bd; 1.
DR   PRINTS; PR00484; PBPGOBP.
DR   SMART; SM00708; PhBP; 1.
DR   SUPFAM; SSF47565; SSF47565; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Pheromone response;
KW   Pheromone-binding; Signal; Transport.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000269|PubMed:2010751,
FT                   ECO:0000269|PubMed:3200861"
FT   CHAIN           27..168
FT                   /note="Pheromone-binding protein"
FT                   /id="PRO_0000012563"
FT   DISULFID        45..80
FT                   /evidence="ECO:0000250"
FT   DISULFID        76..134
FT                   /evidence="ECO:0000250"
FT   DISULFID        123..143
FT                   /evidence="ECO:0000250"
FT   VARIANT         29
FT                   /note="D -> E"
FT   VARIANT         120
FT                   /note="I -> V"
SQ   SEQUENCE   168 AA;  18516 MW;  0FC1F18D1908ADF1 CRC64;
     MNKTTTKMKV AVVAIVVYLA VGNVDSSPDV MKNLCLNFGK ALDECKAEMN LSDSIKDDFA
     NFWVEGYEVS NRDTGCAILC LSKKLDMIDP DGKLHHGNAM EFAKKHGADE AMAKQLLDII
     HNCENSTPPN DDACLKTLDI AKCFKKEIHK LNWAPNMDLV VGEVLAEV