PBURS_ANOGA
ID PBURS_ANOGA Reviewed; 153 AA.
AC Q566B3; Q32TG5; Q7QA00;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Partner of bursicon;
DE AltName: Full=Bursicon subunit beta;
DE Flags: Precursor;
GN Name=pburs {ECO:0000250|UniProtKB:Q9VJS7}; ORFNames=AGAP004506;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1] {ECO:0000312|EMBL:AAX18444.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15703293; DOI=10.1073/pnas.0409916102;
RA Luo C.-W., Dewey E.M., Sudo S., Ewer J., Hsu S.Y., Honegger H.-W.,
RA Hsueh A.J.W.;
RT "Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine
RT knot protein that activates G protein-coupled receptor LGR2.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:2820-2825(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [3] {ECO:0000305, ECO:0000312|EMBL:CAH74225.1}
RP IDENTIFICATION.
RX PubMed=15811337; DOI=10.1016/j.febslet.2005.03.006;
RA Mendive F.M., Van Loy T., Claeysen S., Poels J., Williamson M., Hauser F.,
RA Grimmelikhuijzen C.J.P., Vassart G., Vanden Broeck J.J.M.;
RT "Drosophila molting neurohormone bursicon is a heterodimer and the natural
RT agonist of the orphan receptor DLGR2.";
RL FEBS Lett. 579:2171-2176(2005).
CC -!- FUNCTION: Final heterodimeric neurohormone released at the end of the
CC molting cycle, involved in the sclerotization (tanning) of the insect
CC cuticle, melanization and wing spreading.
CC {ECO:0000250|UniProtKB:Q9VJS7}.
CC -!- SUBUNIT: Heterodimer of burs and pburs. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAX18444.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY823259; AAX18444.1; ALT_INIT; mRNA.
DR EMBL; AAAB01008898; EAA09095.3; -; Genomic_DNA.
DR EMBL; BN000689; CAH74225.1; -; mRNA.
DR RefSeq; XP_313804.3; XM_313804.3.
DR AlphaFoldDB; Q566B3; -.
DR STRING; 7165.AGAP004506-PA; -.
DR PaxDb; Q566B3; -.
DR GeneID; 1274652; -.
DR KEGG; aga:AgaP_AGAP004506; -.
DR CTD; 1274652; -.
DR VEuPathDB; VectorBase:AGAP004506; -.
DR eggNOG; ENOG502S111; Eukaryota.
DR HOGENOM; CLU_145016_0_0_1; -.
DR InParanoid; Q566B3; -.
DR OMA; SKECYCC; -.
DR OrthoDB; 1461272at2759; -.
DR PhylomeDB; Q566B3; -.
DR Proteomes; UP000007062; Chromosome 2R.
DR GO; GO:0031395; C:bursicon neuropeptide hormone complex; IEA:InterPro.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR034441; Bursicon_suB.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR PANTHER; PTHR41151; PTHR41151; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..153
FT /note="Partner of bursicon"
FT /evidence="ECO:0000255"
FT /id="PRO_0000223889"
FT DOMAIN 44..139
FT /note="CTCK"
FT /evidence="ECO:0000255"
FT DISULFID 44..102
FT /evidence="ECO:0000250|UniProtKB:P04275"
FT DISULFID 68..117
FT /evidence="ECO:0000250|UniProtKB:P04275"
FT DISULFID 77..143
FT /evidence="ECO:0000250|UniProtKB:P04275"
FT DISULFID 81..145
FT /evidence="ECO:0000250|UniProtKB:P04275"
FT DISULFID 99..148
FT /evidence="ECO:0000250|UniProtKB:P04275"
FT DISULFID 101
FT /note="Interchain"
FT /evidence="ECO:0000250|UniProtKB:P04275"
SQ SEQUENCE 153 AA; 17183 MW; 975BE17D3EA01D41 CRC64;
MCNSVRTALA ASNCCSIVLC CVLLLTLTLT VAVTAQHNQA DETCETLPSE IHLIKEEYDE
LGRLYRTCNG DVTVNKCEGK CNSQVQPSVI TATGFLKECY CCRESFLRER QLQLTHCYDP
DGVRMTDHES ATMEIRLKEP VDCKCFKCGE MVR
