PBUX_BACSU
ID PBUX_BACSU Reviewed; 438 AA.
AC P42086;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Xanthine permease;
GN Name=pbuX; Synonyms=ypaQ; OrderedLocusNames=BSU22060;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9098051; DOI=10.1128/jb.179.8.2540-2550.1997;
RA Christiansen L.C., Schou S., Nygaard P., Saxild H.H.;
RT "Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX
RT operon and evidence for purine- and nitrogen-controlled expression of genes
RT involved in xanthine salvage and catabolism.";
RL J. Bacteriol. 179:2540-2550(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC 3610 / NRRL NRS-744 / VKM B-501;
RX PubMed=8969496; DOI=10.1099/13500872-142-11-3005;
RA Capuano V., Galleron N., Pujic P., Sorokin A., Ehrlich S.D.;
RT "Organization of the Bacillus subtilis 168 chromosome between kdg and the
RT attachment site of the SP beta prophage: use of long accurate PCR and yeast
RT artificial chromosomes for sequencing.";
RL Microbiology 142:3005-3015(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- FUNCTION: Transport of xanthine in the cell.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X83878; CAA58759.1; -; Genomic_DNA.
DR EMBL; L77246; AAA96612.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14123.1; -; Genomic_DNA.
DR PIR; S51310; S51310.
DR RefSeq; NP_390088.1; NC_000964.3.
DR RefSeq; WP_003230748.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; P42086; -.
DR SMR; P42086; -.
DR STRING; 224308.BSU22060; -.
DR TCDB; 2.A.40.3.1; the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.
DR PaxDb; P42086; -.
DR PRIDE; P42086; -.
DR EnsemblBacteria; CAB14123; CAB14123; BSU_22060.
DR GeneID; 939068; -.
DR KEGG; bsu:BSU22060; -.
DR PATRIC; fig|224308.179.peg.2410; -.
DR eggNOG; COG2233; Bacteria.
DR InParanoid; P42086; -.
DR OMA; WANEMPL; -.
DR PhylomeDB; P42086; -.
DR BioCyc; BSUB:BSU22060-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0042907; F:xanthine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042906; P:xanthine transport; IBA:GO_Central.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR017588; UacT-like.
DR InterPro; IPR006042; Xan_ur_permease.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR TIGRFAMs; TIGR00801; ncs2; 1.
DR TIGRFAMs; TIGR03173; pbuX; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..438
FT /note="Xanthine permease"
FT /id="PRO_0000165962"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 438 AA; 46238 MW; AFB9EDFADFF12E29 CRC64;
MRNGFGKTLS LGIQHVLAMY AGAIVVPLIV GKAMGLTVEQ LTYLVSIDIF MCGVATLLQV
WSNRFFGIGL PVVLGCTFTA VSPMIAIGSE YGVSTVYGSI IASGILVILI SFFFGKLVSF
FPPVVTGSVV TIIGITLMPV AMNNMAGGEG SADFGDLSNL ALAFTVLSII VLLYRFTKGF
IKSVSILIGI LIGTFIAYFM GKVQFDNVSD AAVVQMIQPF YFGAPSFHAA PIITMSIVAI
VSLVESTGVY FALGDLTNRR LTEIDLSKGY RAEGLAVLLG GIFNAFPYTA FSQNVGLVQL
TGIKKNAVIV VTGVILMAFG LFPKIAAFTT IIPSAVLGGA MVAMFGMVIA YGIKMLSRID
FAKQENLLIV ACSVGLGLGV TVVPDIFKQL PSALTLLTTN GIVAGSFTAV VLNIVYNVFS
KAKKIEQEAD LAEQKTAV
