PBX1_XENTR
ID PBX1_XENTR Reviewed; 347 AA.
AC B4F6V6;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Pre-B-cell leukemia transcription factor 1 {ECO:0000250|UniProtKB:P40424};
DE AltName: Full=Homeobox protein pbx1 {ECO:0000250|UniProtKB:P40424};
GN Name=pbx1 {ECO:0000250|UniProtKB:P40424};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:AAI68027.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis {ECO:0000312|EMBL:AAI68027.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a transcriptional activator in complex with isoform 2
CC of meis1, to induce posterior neural and neural crest gene expression,
CC and thereby specify hindbrain and neural crest cell fate. Binds to a
CC highly conserved region in the promoter of the neural crest gene zic3.
CC Required for the nuclear transport or retention of meis1 (By
CC similarity). {ECO:0000250|UniProtKB:Q8QGC4}.
CC -!- SUBUNIT: Forms a heterodimer with meis1; the interaction is necessary
CC for neural fate induction. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P40424}.
CC -!- MISCELLANEOUS: The displayed sequence corresponds to the ortholog of
CC the mammalian isoform B sequences. There is currently no X.tropicalis
CC ortholog sequence for isoform A. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TALE/PBX homeobox family. {ECO:0000255}.
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DR EMBL; BC168027; AAI68027.1; -; mRNA.
DR RefSeq; NP_001135549.1; NM_001142077.1.
DR AlphaFoldDB; B4F6V6; -.
DR SMR; B4F6V6; -.
DR STRING; 8364.ENSXETP00000011400; -.
DR PaxDb; B4F6V6; -.
DR Ensembl; ENSXETT00000081768; ENSXETP00000080135; ENSXETG00000010464.
DR GeneID; 100216094; -.
DR KEGG; xtr:100216094; -.
DR CTD; 5087; -.
DR Xenbase; XB-GENE-1217592; pbx1.
DR eggNOG; KOG0774; Eukaryota.
DR HOGENOM; CLU_041153_1_0_1; -.
DR InParanoid; B4F6V6; -.
DR OrthoDB; 804740at2759; -.
DR Proteomes; UP000008143; Chromosome 4.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000010464; Expressed in brain and 14 other tissues.
DR ExpressionAtlas; B4F6V6; baseline and differential.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005667; C:transcription regulator complex; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0048568; P:embryonic organ development; IBA:GO_Central.
DR GO; GO:0001654; P:eye development; IBA:GO_Central.
DR GO; GO:0014036; P:neural crest cell fate specification; ISS:UniProtKB.
DR GO; GO:0048666; P:neuron development; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR005542; PBX.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03792; PBC; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51978; PBC; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding; Homeobox;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..347
FT /note="Pre-B-cell leukemia transcription factor 1"
FT /id="PRO_0000365099"
FT DOMAIN 38..232
FT /note="PBC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT DNA_BIND 233..295
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 45..124
FT /note="PBC-A"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT REGION 127..232
FT /note="PBC-B"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT REGION 318..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 347 AA; 38488 MW; 18DBB1F947CEFE52 CRC64;
MDDQPRLMHS HPGVGMAGHP SLSQHMQDGT GANEGEGGRK QDIGDILQQI MTITDQSLDE
AQARKHALNC HRMKPALFNV LCEIKEKTVL SIRGAQEEEP ADPQLMRLDN MLLAEGVAGP
EKGGGSAAAA AAAAASGGAG ADNSAEHSDY RAKLSQIRQI YHTELEKYEQ ACNEFTTHVM
NLLREQSRTR PISPKEIERM VSIIHRKFSS IQMQLKQSTC EAVMILRSRF LDARRKRRNF
NKQATEILNE YFYSHLSNPY PSEEAKEELA KKCAITVSQV SNWFGNKRIR YKKNIGKFQE
EANIYAAKTA VNATNVSVHG SQANSPSTPS SAGGYPSPCY QSDRRIQ
