ID   PBX2_XENLA              Reviewed;         445 AA.
AC   Q6IR52;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Pre-B-cell leukemia transcription factor 2 {ECO:0000250|UniProtKB:P40425};
DE   AltName: Full=Homeobox protein pbx2 {ECO:0000250|UniProtKB:P40425};
GN   Name=pbx2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH71048.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte {ECO:0000312|EMBL:AAH71048.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator that binds the sequence 5'-
CC       ATCAATCAA-3'. {ECO:0000250|UniProtKB:P40425}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P40425,
CC       ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the TALE/PBX homeobox family. {ECO:0000255}.
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DR   EMBL; BC071048; AAH71048.1; -; mRNA.
DR   RefSeq; NP_001085013.1; NM_001091544.1.
DR   AlphaFoldDB; Q6IR52; -.
DR   SMR; Q6IR52; -.
DR   MaxQB; Q6IR52; -.
DR   DNASU; 432077; -.
DR   GeneID; 432077; -.
DR   CTD; 432077; -.
DR   Xenbase; XB-GENE-865111; pbx2.L.
DR   OrthoDB; 804740at2759; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   Bgee; 432077; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005667; C:transcription regulator complex; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR005542; PBX.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03792; PBC; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS51978; PBC; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..445
FT                   /note="Pre-B-cell leukemia transcription factor 2"
FT                   /id="PRO_0000365108"
FT   DOMAIN          42..236
FT                   /note="PBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT   DNA_BIND        237..299
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          13..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          49..128
FT                   /note="PBC-A"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT   REGION          131..236
FT                   /note="PBC-B"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT   REGION          319..338
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   445 AA;  49403 MW;  B0ED04936CEBA080 CRC64;
     MDEQGRLMQA RGVGIPGLPI HGGPQTLTPH PMHEPPTDNG EPRKQDIGDI LQQIMTITDQ
     SLDEAQAKKH ALNCHRMKPA LFSVLCEIKE KTGLSIRNSQ EEEPVDPQLM RLDNMLLAEG
     VAGPEKGGGS AAAAAAAAAS GGVSPDNSIE HSDYRNKLSQ IRQIYHAELE KYEQACNEFT
     THVMNLLREQ SRTRPISPKE IERMVGIIHR KFSSIQMQLK QSTCEAVMIL RSRFLDARRK
     RRNFSKQATE VLNEYFYSHL SNPYPSEEAK EELAKKCSIT VSQVSNWFGN KRIRYKKNIG
     KFQEEANIYA VKTAVSVTQG GHSGANSPTT PTSAGSGGSF NLSGSNDMFM AMQGFRCTAR
     GRSGQMEGGK KLSPLRLSPR PQKDLAVSTL TPRTELFILC APSVYQTRLF TWTKPLPRLT
     PILWNYQGEG LWKSTLPLPP SLPSN