ID   PBX2_XENTR              Reviewed;         422 AA.
AC   B3DM47;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Pre-B-cell leukemia transcription factor 2 {ECO:0000250|UniProtKB:P40425};
DE   AltName: Full=Homeobox protein pbx2 {ECO:0000250|UniProtKB:P40425};
GN   Name=pbx2 {ECO:0000312|EMBL:AAI67699.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAI67699.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tail bud {ECO:0000312|EMBL:AAI67699.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator that binds the sequence 5'-
CC       ATCAATCAA-3'. {ECO:0000250|UniProtKB:P40425}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P40425,
CC       ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the TALE/PBX homeobox family. {ECO:0000255}.
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DR   EMBL; BC167699; AAI67699.1; -; mRNA.
DR   RefSeq; NP_001122133.1; NM_001128661.1.
DR   AlphaFoldDB; B3DM47; -.
DR   SMR; B3DM47; -.
DR   STRING; 8364.ENSXETP00000047860; -.
DR   PaxDb; B3DM47; -.
DR   GeneID; 100101713; -.
DR   KEGG; xtr:100101713; -.
DR   CTD; 5089; -.
DR   Xenbase; XB-GENE-484669; pbx2.
DR   eggNOG; KOG0774; Eukaryota.
DR   HOGENOM; CLU_041153_0_0_1; -.
DR   InParanoid; B3DM47; -.
DR   OrthoDB; 804740at2759; -.
DR   PhylomeDB; B3DM47; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000005223; Expressed in neurula embryo and 14 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005667; C:transcription regulator complex; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IBA:GO_Central.
DR   GO; GO:0048568; P:embryonic organ development; IBA:GO_Central.
DR   GO; GO:0001654; P:eye development; IBA:GO_Central.
DR   GO; GO:0048666; P:neuron development; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR005542; PBX.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03792; PBC; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS51978; PBC; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..422
FT                   /note="Pre-B-cell leukemia transcription factor 2"
FT                   /id="PRO_0000365100"
FT   DOMAIN          42..236
FT                   /note="PBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT   DNA_BIND        237..299
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          49..128
FT                   /note="PBC-A"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT   REGION          131..236
FT                   /note="PBC-B"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT   REGION          319..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          353..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        374..388
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..422
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   422 AA;  46267 MW;  02166584F480F25E CRC64;
     MDEQGRLMQA RGVGIPGHPI HGGPQTLTPH PMHEPPADNG EPRKQDIGDI LQQIMTITDQ
     SLDEAQAKKH ALNCHRMKPA LFSVLCEIKE KTGLSIRNTQ EEEPVDPQLM RLDNMLLAEG
     VAGPEKGGGS AAAAAAAAAS GGVSPDNSIE HSDYRNKLSQ IRQIYHAELE KYEQACNEFT
     THVMNLLREQ SRTRPISPKE IERMVGIIHR KFSSIQMQLK QSTCEAVMIL RSRFLDARRK
     RRNFSKQATE VLNEYFYSHL SNPYPSEEAK EELAKKCGIT VSQVSNWFGN KRIRYKKNIG
     KFQEEANIYA VKTAVSVAQG GHSGANSPTT PTSAGSGGSF NLSGSNDMFM AMQGLNGDSY
     PPSQVESLRH TMGPGYSDSL SANQMYSPRE IRANGGWQEA VTPSSVTSPT EGPGSVHSDT
     SN