PC11X_GORGO
ID PC11X_GORGO Reviewed; 1347 AA.
AC Q6X862; Q6X863;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Protocadherin-11 X-linked;
DE Short=Protocadherin-11;
DE AltName: Full=Protocadherin on the X chromosome;
DE Flags: Precursor;
GN Name=PCDH11X; Synonyms=PCDH11, PCDHX;
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Williams N.A., Crow T.J.;
RT "Protocadherin X/Y, a neural cell surface adhesion molecule subject to
RT differential and domain-specific selection in the course of hominid
RT evolution.";
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6X862-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6X862-2; Sequence=VSP_017988, VSP_017989;
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DR EMBL; AY249903; AAP79575.1; -; Genomic_DNA.
DR EMBL; AY249901; AAP79575.1; JOINED; Genomic_DNA.
DR EMBL; AY249902; AAP79575.1; JOINED; Genomic_DNA.
DR EMBL; AY249908; AAP79576.1; -; Genomic_DNA.
DR EMBL; AY249901; AAP79576.1; JOINED; Genomic_DNA.
DR EMBL; AY249902; AAP79576.1; JOINED; Genomic_DNA.
DR EMBL; AY249904; AAP79576.1; JOINED; Genomic_DNA.
DR EMBL; AY249905; AAP79576.1; JOINED; Genomic_DNA.
DR EMBL; AY249906; AAP79576.1; JOINED; Genomic_DNA.
DR EMBL; AY249907; AAP79576.1; JOINED; Genomic_DNA.
DR AlphaFoldDB; Q6X862; -.
DR SMR; Q6X862; -.
DR STRING; 9593.ENSGGOP00000019373; -.
DR eggNOG; ENOG502QPMK; Eukaryota.
DR InParanoid; Q6X862; -.
DR Proteomes; UP000001519; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR InterPro; IPR013585; Protocadherin.
DR Pfam; PF00028; Cadherin; 6.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF08374; Protocadherin; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 7.
PE 3: Inferred from homology;
KW Alternative splicing; Calcium; Cell adhesion; Cell membrane; Glycoprotein;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..1347
FT /note="Protocadherin-11 X-linked"
FT /id="PRO_0000232759"
FT TOPO_DOM 24..812
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 813..833
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 834..1347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 26..139
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 140..249
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 250..355
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 362..466
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 467..570
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 571..673
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 677..795
FT /note="Cadherin 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT REGION 1057..1091
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1097..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1326..1347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 344
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 553
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 773
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1012..1025
FT /note="PMKEVVRSCTPMKE -> TDSRTSTIEICSEI (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_017988"
FT VAR_SEQ 1026..1347
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_017989"
SQ SEQUENCE 1347 AA; 147688 MW; 87D38CC6B929C9EB CRC64;
MDLLSGTYIF AVLLACVVFH SGAQEKNYTI REEMPENVLI GDLLKDLNLS LIPNKSLTTA
MQFKLVYKTG DVPLIRIEED TGEIFTTGAR IDREKLCAGI PRDEHCFYEV EVAILPDEIF
RLVKIRFLIE DINDNAPLFP ATVINISIPE NSAINSKYTL PAAVDPDVGI NGVQNYELIK
SQNMFGLDVI ETPEGDKMPQ LIVQKELDRE KKDTYVMKVK VEDGGFPQRS STAILQVSVT
DTNDNHPVFK ETEIEVSIPE NAPVGTSVTQ LHATDADIGE NAKIHFSFSN LVSNIARRLF
HLNATTGLIT IKEPLDREET PNHKLLVLAS DGGLMPARAM VLVNVTDVND NVPSIDIRYI
VNPVNDTVVL SENIPLNTKI ALITVTDKDA DHNGRVTCFT DHEIPFRLRP VFSNQFLLET
AAYLDYESTK EYAIKLLAAD AGKPPLNQSA MLFIKVKDEN DNAPVFTQSF VTVSIPENNS
PGIQLTKVSA TDADSGPNAE INYLLGPDAP PEFSLDRRTG MLTVVKKLDR EKEDKYLFTI
LAKDNGVPPL TSNVTVFVSI IDQNDNSPVF THNEYNFYVP ENLPRHGTVG LITVTDPDYG
DNSAVTLSIL DENDDFTIDS QTGVIRPNIS FDREKQESYT FYVKAEDGGR VSRSSSAKVT
INVVDVNDNK PVFIVPPSNY SYELVLPSTN PGTVVFQVIA VDNDTGMNAE VRYSIVGGNT
RDLFAIDQET GNITLMEKCD VTDLGLHRVL VKANDLGQPD SLFSVVIVNL FVNESVTNAT
LINELVRKSI EAPVTPNTEI ADVSSPTNDY VKILVAAVAG TITVVVVIFI TAVVRCRQAP
HLKAAQKNKQ NSEWATPNPE NRQMIMMKKR KKKKKHSPKN LLLNFVTIEE TKADDVDSDG
NRVTLDLPID LEEQTMGKYD WVTTPTTFKP DSPDLARHYK SASPQPAFQI QPETPLNSKH
HIIQELPLDN TFVACDSISK CSSSSSDPYS VSDCGYPVTT FEVPVSVHTR PPMKEVVRSC
TPMKESTTME IWIHPQPQRK SEGKVAGKSQ RRVTFHLPEG SQESSSDGGL GDHDAGSLTS
TSHGLPLGYP QEEYFDRATP SNRTEGDGNS DPESTFIPGL KKAAEITVQP TVEEASDNCT
QECLIYGHSD ACWMPASLDH SSSLQAQASA LCHSPPLSQA STQHHSPPVT QTIALCHSPP
VTQTIALCHS PPPIQVSALR HSPPLVQATA LHHSPPSAQA SALCYSPPLA QAAAISHSSP
LPQVIALHRS QAQSSVSLQQ GWVQGADGLC SVDQGVQGSA TSQFYTMSER LHASDDSIKV
IPLTTFTPRQ QARPSRGDSP IMEEHPL
