PC11X_PANTR
ID PC11X_PANTR Reviewed; 1347 AA.
AC Q71M42; Q71M43;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Protocadherin-11 X-linked;
DE Short=Protocadherin-11;
DE AltName: Full=Protocadherin on the X chromosome;
DE Short=PCDH-X;
DE Flags: Precursor;
GN Name=PCDH11X; Synonyms=PCDH11, PCDHX;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Williams N.A., Crow T.J.;
RT "Protocadherin X/Y, a neural cell surface adhesion molecule subject to
RT differential and domain-specific selection in the course of hominid
RT evolution.";
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q71M42-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q71M42-2; Sequence=VSP_017990, VSP_017991;
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DR EMBL; AF461067; AAQ04772.1; -; Genomic_DNA.
DR EMBL; AF461065; AAQ04772.1; JOINED; Genomic_DNA.
DR EMBL; AF461066; AAQ04772.1; JOINED; Genomic_DNA.
DR EMBL; AF461072; AAQ04773.1; -; Genomic_DNA.
DR EMBL; AF461065; AAQ04773.1; JOINED; Genomic_DNA.
DR EMBL; AF461066; AAQ04773.1; JOINED; Genomic_DNA.
DR EMBL; AF461069; AAQ04773.1; JOINED; Genomic_DNA.
DR EMBL; AF461071; AAQ04773.1; JOINED; Genomic_DNA.
DR EMBL; AF461070; AAQ04773.1; JOINED; Genomic_DNA.
DR EMBL; AF461068; AAQ04773.1; JOINED; Genomic_DNA.
DR RefSeq; XP_009437584.2; XM_009439309.2.
DR RefSeq; XP_009437585.2; XM_009439310.2. [Q71M42-1]
DR RefSeq; XP_016799002.1; XM_016943513.1.
DR AlphaFoldDB; Q71M42; -.
DR SMR; Q71M42; -.
DR STRING; 9598.ENSPTRP00000037987; -.
DR PaxDb; Q71M42; -.
DR Ensembl; ENSPTRT00000041121; ENSPTRP00000037987; ENSPTRG00000022079. [Q71M42-1]
DR Ensembl; ENSPTRT00000087507; ENSPTRP00000081323; ENSPTRG00000050456. [Q71M42-2]
DR GeneID; 104001127; -.
DR KEGG; ptr:104001127; -.
DR CTD; 27328; -.
DR eggNOG; ENOG502QPMK; Eukaryota.
DR GeneTree; ENSGT00940000158335; -.
DR InParanoid; Q71M42; -.
DR OMA; NIITIRT; -.
DR Proteomes; UP000002277; Chromosome X.
DR Bgee; ENSPTRG00000022079; Expressed in temporal lobe and 6 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR InterPro; IPR013585; Protocadherin.
DR Pfam; PF00028; Cadherin; 6.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF08374; Protocadherin; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 7.
PE 3: Inferred from homology;
KW Alternative splicing; Calcium; Cell adhesion; Cell membrane; Glycoprotein;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..1347
FT /note="Protocadherin-11 X-linked"
FT /id="PRO_0000232760"
FT TOPO_DOM 24..812
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 813..833
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 834..1347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 26..139
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 140..249
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 250..355
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 362..466
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 467..570
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 571..673
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 677..795
FT /note="Cadherin 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT REGION 1057..1091
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1097..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1325..1347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 344
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 553
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 773
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1012..1025
FT /note="PMKEVVRSCTPMKE -> TDSRTSTIEICSEI (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_017990"
FT VAR_SEQ 1026..1347
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_017991"
SQ SEQUENCE 1347 AA; 147603 MW; FA4333D258CA10FF CRC64;
MDLLSGTYIF AVLLACVVFH SGAQEKNYTI REEMPENVLI GDLLKDLNLS LIPNKSLTTA
MQFKLVYKTG DVPLIRIEED TGEIFTTGAR IDREKLCAGI PRDEHCFYEV EVAILPDEIF
RLVKIRFLIE DINDNAPLFP ATVINISIPE NSAINSKYTL PAAVDPDVGT NGVQNYELIK
SQNIFGLDVI ETPEGDKMPQ LIVQKELDRE EKDTYVMKVK VEDGGFPQRS STAILQVSVT
DTNDNHPVFK ETEIEVSIPE NAPVGTSVTQ LHATDADIGE NAKIHFSFSN LVSNIARRLF
HLNATTGLIT IKEPLDREET PNHKLLVLAS DGGLMPARAM VLVNVTDVND NVPSIDIRYI
VNPVNDTVVL SENIPLNTKI ALITVTDKDA DHNGRVTCFT DHEIPFRLRP VFSNQFLLET
AAYLDYESTK EYAIKLLAAD AGKPPLNQSA MLFIKVKDEN DNAPVFTQSF VTVSIPENNS
PGIQLTKVSA TDADSGPNAE INYLLGPDAP PEFSLDRRTG MLTVVKKLDR EKEDKYLFTI
LAKDNGVPPL TSNVTVFVSI IDQNDNSPVF THNEYNFYVP ENLPRHGTVG LITVTDPDYG
DNSAVTLSIL DENDDFTIDS QTGVIRPNIS FDREKQESYT FYVKAEDGGR VSRSSSAKVT
INVVDVNDNK PVFIVPPSNY SYELVLPSTN PGTVVFQVMA VDNDTGMNAE VRYSIVGGNT
RDLFAIDQET GNITLMEKCD VTDLGLHRVL VKANDLGQPD SLFSVVIVNL FVNESVTNAT
LINELVRKST EAPVTPNTEI ADVSSPTSDY VKILVAAVAG TITVVVVIFI TAVVRCRQAP
HLKAAQKNKQ NSEWATPNPE NRQMIMMKKR KKKKKHSPKN LLLNFVTIEE TKADDVDSDG
NRVTLDLPID LEEQTMGKYN WVTTPTTFKP DSPDLARHYK SASPQPAFQI QPETPLNSKH
HIIQELPLDN TFVACDSISK CSSSSSDPYS VSDCGYPVTT FEVPVSVHTR PPMKEVVRSC
TPMKESTTME IWIHPQPQRK SEGKVAGKSQ RRVTFHLPEG SQESSSDGGL GDHDAGSLTS
TSHGLPLGYP QEEYFDRATP SNRTEGDGNS DPESTFIPGL KKAAEITVQP TVEEASDNCT
QECLIYGHSD ACWMPASLDH SSSSQAQASA LCHSPPLSQA STQHHSPPVT QTIALCHSPP
VTQTIALCHS PPPIQVSALH HSPPLVQATA LHHSPPSAQA SALCYSPPLA QAAAISHSSP
LPQVIALHRS QAQSSVSLQQ GWVQGADGLC SVDQGVQGSA TSQFYTMSER LHPSDDSIKV
IPLTTFTPRQ QARPSRGDSP VMEEHPL
