PC11X_PONPY
ID PC11X_PONPY Reviewed; 1347 AA.
AC Q6WXV7; Q6WXV8;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Protocadherin-11 X-linked;
DE Short=Protocadherin-11;
DE AltName: Full=Protocadherin on the X chromosome;
DE Short=PCDH-X;
DE Flags: Precursor;
GN Name=PCDH11X; Synonyms=PCDH11, PCDHX;
OS Pongo pygmaeus (Bornean orangutan).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9600;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Williams N.A., Crow T.J.;
RT "Protocadherin X/Y, a neural cell surface adhesion molecule subject to
RT differential and domain-specific selection in the course of hominid
RT evolution.";
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6WXV7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6WXV7-2; Sequence=VSP_017994, VSP_017995;
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DR EMBL; AY264879; AAP92137.1; -; Genomic_DNA.
DR EMBL; AY264877; AAP92137.1; JOINED; Genomic_DNA.
DR EMBL; AY264878; AAP92137.1; JOINED; Genomic_DNA.
DR EMBL; AY264884; AAP92138.1; -; Genomic_DNA.
DR EMBL; AY264877; AAP92138.1; JOINED; Genomic_DNA.
DR EMBL; AY264878; AAP92138.1; JOINED; Genomic_DNA.
DR EMBL; AY264881; AAP92138.1; JOINED; Genomic_DNA.
DR EMBL; AY264883; AAP92138.1; JOINED; Genomic_DNA.
DR EMBL; AY264882; AAP92138.1; JOINED; Genomic_DNA.
DR EMBL; AY264880; AAP92138.1; JOINED; Genomic_DNA.
DR AlphaFoldDB; Q6WXV7; -.
DR SMR; Q6WXV7; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR InterPro; IPR013585; Protocadherin.
DR Pfam; PF00028; Cadherin; 6.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF08374; Protocadherin; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 7.
PE 3: Inferred from homology;
KW Alternative splicing; Calcium; Cell adhesion; Cell membrane; Glycoprotein;
KW Membrane; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..1347
FT /note="Protocadherin-11 X-linked"
FT /id="PRO_0000232762"
FT TOPO_DOM 24..812
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 813..833
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 834..1347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 26..139
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 140..249
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 250..355
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 362..466
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 467..570
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 571..673
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 677..795
FT /note="Cadherin 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT REGION 1031..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1091
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1097..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1325..1347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 344
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 553
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 773
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1012..1025
FT /note="PMKEVVRSCTPMKE -> TDSRTSTIEICSEI (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_017994"
FT VAR_SEQ 1026..1347
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_017995"
SQ SEQUENCE 1347 AA; 147655 MW; 8BAFA91EB2227A21 CRC64;
MDLLSGTYIF AVLLACVVFH SGAQEKNYTI REEMPENVLI GDLLKDLNLS LIPNKSLTTA
MQFKLVYKTG DVPLTRIEED TGEIFTTGAR IDREKLCAGI PRDEHCFYEV EVAILPDEIF
RLVKIRFLIE DINDNAPLFP ATVINISIPE NSAINSKYTL PAAVDPDVGI NGVQNYELIK
SQNIFGLDVI ETPEGDKMPQ LIVQKELDRE EKDTYVMKVK VEDGGFPQRS STAILQVSVT
DTNDNHPVFK ETEIEVSIPE NAPVGTSVTQ LHATDADIGE NAKIHFSFSN LVSNIARRLF
HLNATTGLIT IKEPLDREET PNHKLLVLAS DGGLMPARAM VLVNVTDVND NVPSIDIRYI
VNPINDTVVL SENIPLNTKI ALITVTDKDA DHNGRVTCFT DHEIPFRLRP VFSNQFLLET
AAYLDYESTK EYAIKLLAAD AGKPPLNQSA MLFIKVKDEN DNAPVFTQSF VTVSIPENNS
PGIQLTKVSA TDADSGPNAE INYLLGPDAP PEFSLDRRTG MLTVVKKLDR EKEDKYLFTI
LAKDNGVPPL TSNVTVFVSI IDQNDNSPVF THNEYNFYVP ENLPRHGTVG LITVTDPDYG
DNSAVTLSIL DENDDFTIDS QTGVIRPNIS FDREKQESYT FYVKAEDGGR VSRSSSAKVT
INVVDVNDNK PVFIVPPSNY SYELVLPSTN PGTVVFQVIA VDNDTGMNAE VRYSIVGGNT
RDLFAIDQET GNITLMEKCD VTDLGLHRVL VKANDLGQPD SLFSVVIVNL FVNESVTNAT
LINELVRKSI EAPVTPNTEI ADVSSPTSDY VKILVAAVAG TVTVVVVIFI TAVVRCRQAP
HLKAAQKNKQ NSEWATPNPE NRQMIMMKKK KKKKKHSPKN LLLNFVTIEE TKADDVDSDG
NRITLDLPID LEEQTMGKYN WVTTPTTFKP DSPDLARHYK SASPQPAFQI QPETPLNSKH
HIIQELPLDN TFVACDSISK RSSSSSDPYS VSDCGYPVTT FEVPVSVHTR PPMKEVVRSC
TPMKESTTME IWIHPQPQRK SEGKGAGKSQ RRVTFHLPEG SQESSSDGGL GEHDAGSLTS
TSHGLPLGYP QEEYFDRATP SNRTEGDGNS DPESTFIPGL KKAAEITVQP TVEEASDNCT
QECLIYGHSD ACWMPASLDH SSSSQAQASA LCHSPPLSQA STQHHSPPVT QTIALCHSPP
VTQTIALCHS PPPIQVSALH HSPPLVQATA LRHSPPSAQA SALCYSPPLA QAAAISHSSP
LPQVIALHRS QAQSSVSLQQ GWVQGAEGLC SVDQGVQGSA TSQFYTMSER LHPSDDSIKV
IPLTTFTPRQ QARPSRGDSP IMEEHPL
