PC4L1_HUMAN
ID PC4L1_HUMAN Reviewed; 68 AA.
AC A6NKN8; B2RV24; B9EJG4;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 3.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Purkinje cell protein 4-like protein 1;
DE Short=PCP4-like protein 1;
GN Name=PCP4L1; Synonyms=IQM1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Testis, and Urinary bladder;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the PCP4 family. {ECO:0000305}.
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DR EMBL; AL592295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC028905; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC147003; AAI47004.1; -; mRNA.
DR EMBL; BC147004; AAI47005.1; -; mRNA.
DR CCDS; CCDS53412.1; -.
DR RefSeq; NP_001096036.1; NM_001102566.1.
DR AlphaFoldDB; A6NKN8; -.
DR SMR; A6NKN8; -.
DR BioGRID; 576410; 12.
DR IntAct; A6NKN8; 2.
DR STRING; 9606.ENSP00000426296; -.
DR iPTMnet; A6NKN8; -.
DR PhosphoSitePlus; A6NKN8; -.
DR BioMuta; PCP4L1; -.
DR MassIVE; A6NKN8; -.
DR PaxDb; A6NKN8; -.
DR PeptideAtlas; A6NKN8; -.
DR PRIDE; A6NKN8; -.
DR ProteomicsDB; 1423; -.
DR Antibodypedia; 74073; 11 antibodies from 9 providers.
DR DNASU; 654790; -.
DR Ensembl; ENST00000504449.2; ENSP00000426296.1; ENSG00000248485.2.
DR GeneID; 654790; -.
DR KEGG; hsa:654790; -.
DR MANE-Select; ENST00000504449.2; ENSP00000426296.1; NM_001102566.2; NP_001096036.1.
DR UCSC; uc001gad.3; human.
DR CTD; 654790; -.
DR GeneCards; PCP4L1; -.
DR HGNC; HGNC:20448; PCP4L1.
DR HPA; ENSG00000248485; Tissue enhanced (brain, pituitary gland).
DR neXtProt; NX_A6NKN8; -.
DR OpenTargets; ENSG00000248485; -.
DR PharmGKB; PA143485573; -.
DR VEuPathDB; HostDB:ENSG00000248485; -.
DR eggNOG; ENOG502SDAE; Eukaryota.
DR GeneTree; ENSGT00530000064299; -.
DR HOGENOM; CLU_202697_0_0_1; -.
DR InParanoid; A6NKN8; -.
DR OMA; PCEKASA; -.
DR PhylomeDB; A6NKN8; -.
DR TreeFam; TF336068; -.
DR PathwayCommons; A6NKN8; -.
DR SignaLink; A6NKN8; -.
DR BioGRID-ORCS; 654790; 14 hits in 1059 CRISPR screens.
DR ChiTaRS; PCP4L1; human.
DR GenomeRNAi; 654790; -.
DR Pharos; A6NKN8; Tdark.
DR PRO; PR:A6NKN8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; A6NKN8; protein.
DR Bgee; ENSG00000248485; Expressed in oocyte and 143 other tissues.
DR Genevisible; A6NKN8; HS.
DR InterPro; IPR033234; PCP4-like_1.
DR PANTHER; PTHR15359:SF5; PTHR15359:SF5; 1.
PE 3: Inferred from homology;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..68
FT /note="Purkinje cell protein 4-like protein 1"
FT /id="PRO_0000331432"
FT DOMAIN 45..68
FT /note="IQ"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 8
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6W8Q3"
SQ SEQUENCE 68 AA; 7476 MW; FBCC36204571B6EE CRC64;
MSELNTKTSP ATNQAAGQEE KGKAGNVKKA EEEEEIDIDL TAPETEKAAL AIQGKFRRFQ
KRKKDPSS
