PC4L1_MOUSE
ID PC4L1_MOUSE Reviewed; 68 AA.
AC Q6W8Q3; Q9CW92;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Purkinje cell protein 4-like protein 1;
DE Short=PCP4-like protein 1;
GN Name=Pcp4l1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=C57BL/6J;
RX PubMed=15053978; DOI=10.1016/j.modgep.2003.11.001;
RA Bulfone A., Caccioppoli C., Pardini C., Faedo A., Martinez S., Banfi S.;
RT "Pcp4l1, a novel gene encoding a Pcp4-like polypeptide, is expressed in
RT specific domains of the developing brain.";
RL Gene Expr. Patterns 4:297-301(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney, and Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-8, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-8, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- TISSUE SPECIFICITY: Expressed in laminar and nuclear structures of the
CC CNS. {ECO:0000269|PubMed:15053978}.
CC -!- DEVELOPMENTAL STAGE: First detected at 9.5 dpc in the neural tube.
CC Expressed at early stages of development in the isthmus and in
CC metencephalic and mesencephalic roof plates. At later stages of
CC development, it is expressed in structures corresponding to
CC circumventricular organs which in adult control the production of the
CC cerebrospinal fluid. {ECO:0000269|PubMed:15053978}.
CC -!- SIMILARITY: Belongs to the PCP4 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB22346.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC27734.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY304481; AAQ74773.1; -; mRNA.
DR EMBL; AK002772; BAB22346.1; ALT_INIT; mRNA.
DR EMBL; AK032164; BAC27734.1; ALT_INIT; mRNA.
DR CCDS; CCDS48441.1; -.
DR RefSeq; NP_079833.1; NM_025557.1.
DR AlphaFoldDB; Q6W8Q3; -.
DR SMR; Q6W8Q3; -.
DR STRING; 10090.ENSMUSP00000106964; -.
DR iPTMnet; Q6W8Q3; -.
DR PhosphoSitePlus; Q6W8Q3; -.
DR MaxQB; Q6W8Q3; -.
DR PaxDb; Q6W8Q3; -.
DR PeptideAtlas; Q6W8Q3; -.
DR PRIDE; Q6W8Q3; -.
DR ProteomicsDB; 288110; -.
DR Antibodypedia; 74073; 11 antibodies from 9 providers.
DR Ensembl; ENSMUST00000111332; ENSMUSP00000106964; ENSMUSG00000038370.
DR GeneID; 66425; -.
DR KEGG; mmu:66425; -.
DR UCSC; uc009uzy.1; mouse.
DR CTD; 654790; -.
DR MGI; MGI:1913675; Pcp4l1.
DR VEuPathDB; HostDB:ENSMUSG00000038370; -.
DR eggNOG; ENOG502SDAE; Eukaryota.
DR GeneTree; ENSGT00530000064299; -.
DR HOGENOM; CLU_202697_0_0_1; -.
DR InParanoid; Q6W8Q3; -.
DR OMA; PCEKASA; -.
DR OrthoDB; 1635294at2759; -.
DR TreeFam; TF336068; -.
DR BioGRID-ORCS; 66425; 4 hits in 68 CRISPR screens.
DR ChiTaRS; Pcp4l1; mouse.
DR PRO; PR:Q6W8Q3; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q6W8Q3; protein.
DR Bgee; ENSMUSG00000038370; Expressed in choroid plexus of fourth ventricle and 164 other tissues.
DR Genevisible; Q6W8Q3; MM.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033234; PCP4-like_1.
DR PANTHER; PTHR15359:SF5; PTHR15359:SF5; 1.
DR PROSITE; PS50096; IQ; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..68
FT /note="Purkinje cell protein 4-like protein 1"
FT /id="PRO_0000331433"
FT DOMAIN 45..68
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 8
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
SQ SEQUENCE 68 AA; 7502 MW; 6CC0060A736C6527 CRC64;
MSELNTKTPP AANQASDPEE KGKPGSIKKA EEEEEIDIDL TAPETEKAAL AIQGKFRRFQ
KRKKDSSS
