PCAI_ACIAD
ID PCAI_ACIAD Reviewed; 228 AA.
AC Q43973; Q43933;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=3-oxoadipate CoA-transferase subunit A;
DE EC=2.8.3.6;
DE AltName: Full=Beta-ketoadipate:succinyl-CoA transferase subunit A;
GN Name=pcaI; OrderedLocusNames=ACIAD1704;
GN and
GN Name=catI; OrderedLocusNames=ACIAD1448;
OS Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=62977;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-34 (PCAI).
RX PubMed=8063101; DOI=10.1016/0378-1119(94)90829-x;
RA Kowalchuk G.A., Hartnett G.B., Benson A., Houghton J.E., Ngai K.-L.,
RA Ornston L.N.;
RT "Contrasting patterns of evolutionary divergence within the Acinetobacter
RT calcoaceticus pca operon.";
RL Gene 146:23-30(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CATI).
RX PubMed=8125318; DOI=10.1016/0378-1119(94)90783-8;
RA Shanley M.S., Harrison A., Parales R.E., Kowalchuk G., Mitchell D.J.,
RA Ornston L.N.;
RT "Unusual G + C content and codon usage in catIJF, a segment of the ben-cat
RT supra-operonic cluster in the Acinetobacter calcoaceticus chromosome.";
RL Gene 138:59-65(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (PCAI AND CATI).
RC STRAIN=ATCC 33305 / BD413 / ADP1;
RX PubMed=15514110; DOI=10.1093/nar/gkh910;
RA Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L.,
RA Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N.,
RA Weissenbach J., Marliere P., Cohen G.N., Medigue C.;
RT "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1,
RT a versatile and naturally transformation competent bacterium.";
RL Nucleic Acids Res. 32:5766-5779(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-oxoadipate + succinyl-CoA = 3-oxoadipyl-CoA + succinate;
CC Xref=Rhea:RHEA:12048, ChEBI:CHEBI:15775, ChEBI:CHEBI:30031,
CC ChEBI:CHEBI:57292, ChEBI:CHEBI:57348; EC=2.8.3.6;
CC -!- PATHWAY: Aromatic compound metabolism; beta-ketoadipate pathway;
CC acetyl-CoA and succinyl-CoA from 3-oxoadipate: step 1/2.
CC -!- SUBUNIT: Heterodimer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the 3-oxoacid CoA-transferase subunit A family.
CC {ECO:0000305}.
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DR EMBL; L05770; AAC37146.1; -; Genomic_DNA.
DR EMBL; AF009224; AAC46432.1; -; Genomic_DNA.
DR EMBL; CR543861; CAG68546.1; -; Genomic_DNA.
DR EMBL; CR543861; CAG68311.1; -; Genomic_DNA.
DR PIR; A44570; A44570.
DR RefSeq; WP_004925451.1; NC_005966.1.
DR AlphaFoldDB; Q43973; -.
DR SMR; Q43973; -.
DR STRING; 62977.ACIAD1448; -.
DR EnsemblBacteria; CAG68311; CAG68311; ACIAD1448.
DR EnsemblBacteria; CAG68546; CAG68546; ACIAD1704.
DR GeneID; 45234091; -.
DR GeneID; 67510886; -.
DR KEGG; aci:ACIAD1448; -.
DR KEGG; aci:ACIAD1704; -.
DR eggNOG; COG1788; Bacteria.
DR HOGENOM; CLU_019942_2_1_6; -.
DR OMA; HDGATVM; -.
DR OrthoDB; 1660857at2; -.
DR BioCyc; ASP62977:ACIAD_RS06690-MON; -.
DR BioCyc; ASP62977:ACIAD_RS07850-MON; -.
DR UniPathway; UPA00157; UER00262.
DR Proteomes; UP000000430; Chromosome.
DR GO; GO:0047569; F:3-oxoadipate CoA-transferase activity; IEA:UniProtKB-EC.
DR GO; GO:0042952; P:beta-ketoadipate pathway; IEA:UniProtKB-UniPathway.
DR InterPro; IPR012792; 3-oxoacid_CoA-transf_A.
DR InterPro; IPR004165; CoA_trans_fam_I.
DR InterPro; IPR004163; CoA_transf_BS.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR13707; PTHR13707; 1.
DR Pfam; PF01144; CoA_trans; 1.
DR SMART; SM00882; CoA_trans; 1.
DR SUPFAM; SSF100950; SSF100950; 1.
DR TIGRFAMs; TIGR02429; pcaI_scoA_fam; 1.
DR PROSITE; PS01273; COA_TRANSF_1; 1.
PE 1: Evidence at protein level;
KW Aromatic hydrocarbons catabolism; Direct protein sequencing;
KW Reference proteome; Transferase.
FT CHAIN 1..228
FT /note="3-oxoadipate CoA-transferase subunit A"
FT /id="PRO_0000157906"
FT BINDING 25..31
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000255"
SQ SEQUENCE 228 AA; 24074 MW; 157C8270BBA46FC1 CRC64;
MIDKSAATLT EALSQIHDGA TILIGGFGTA GQPAELIDGL IELGRKNLTI VSNNAGNGDY
GLAKLLKTGA VKKIICSFPR QADSYVFDEL YRAGKIELEI VPQGNLACRI QAAGMGLGPI
YTPTGFGTLL AEGKPTLNFD GKDYVLENPI KADFALIKAY KGDRWGNLVY RKSARNFGPI
MAMAANVTIA QVSEVVALGE LDPENVVTPG IFVQHVVPVQ STPASAAP